Projects funded by the NCN

Next-generation sequencing of miRNA transcriptome and functional in vitro study: towards unravelling pathomechanisms and...

Call: OPUS 8 , Panel: NZ2

Principal investigator: prof. Michał Witt

Instytut Genetyki Człowieka PAN

L-asparaginase resistance in childhood ALL with IKZF1, TP53, BCR-ABL1 and iAMP21 alterations.

Call: PRELUDIUM 7 , Panel: NZ5

Principal investigator: Ewa Wrona

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Mechanism of SYK-mediated suppression of differentiation and apoptosis in acute myeloid leukemia (AML)

Call: PRELUDIUM 6 , Panel: NZ5

Principal investigator: dr Anna Polak

Instytut Hematologii i Transfuzjologii

The regulation of vitamin D receptor expression by retinoids

Call: PRELUDIUM 6 , Panel: NZ3

Principal investigator: Aleksandra Marchwicka

Uniwersytet Wrocławski, Wydział Biotechnologii

Genetics of pediatric T-cell acute lymphoblastic leukemia

Call: PRELUDIUM 6 , Panel: NZ5

Principal investigator: Bronisława Szarzyńska-Zawadzka

Instytut Genetyki Człowieka PAN

The role of nucelophosmin-1 exon 12 abnormalities in acute myeloid leukemias and myelodyplastic syndrome

Call: HARMONIA 5 , Panel: NZ5

Principal investigator: dr hab. Krzysztof Giannopoulos

Uniwersytet Medyczny w Lublinie, II Wydział Lekarski z Oddziałem Anglojęzycznym

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Investigation of the role of ficolins in anti-microbial defense in patients suffering from acute myeloid leukaemia, unde...

Call: PRELUDIUM 4 , Panel: NZ6

Principal investigator: Anna Sokołowska

Instytut Biologii Medycznej PAN

Finding a role of LAT adaptor in development of T cell acute lymphoblastic leukemia (T-ALL)

Call: OPUS 3 , Panel: NZ5

Principal investigator: dr hab. Arkadiusz Miążek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

Late neuroanatomical and neuropsychological sequelae of central nervous system prophylaxis in children with acute lympho...

Call: PRELUDIUM 3 , Panel: NZ5

Principal investigator: dr Olga Zając-Spychała

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski I

Search for biomarkers of CNS involvement and neurotoxicity in childhood acute lymphoblastic leukemia: a metabolomic anal...

Call: OPUS 2 , Panel: NZ5

Principal investigator: prof. Wojciech Młynarski

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

Immune Surveillance in Pathogenesis and Clinical Outcome of Childhood Acute Lymphoblastic Leukemia - the Role of PRF1 Ge...

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Aleksandra Jasińska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski z Oddziałem Stomatologicznym

Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Extensive analysis of the immunological profile of pediatric patients with acute lymphoblastic leukemia in order to iden...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Anna Krętowska-Grunwald

Uniwersytet Medyczny w Białymstoku

Differences in the glycoproteomic profile of acute myeloid leukemia (AML) between cytogenetic and risk groups according ...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Tomasz Pieńkowski

Uniwersytet Medyczny w Białymstoku

Heterogeneity immunocompetent cells during chimeric antigen receptor T cell (CAR-T) CD19 immunotherapy.

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Aleksandra Oszer

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Krzysztof Domka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Dissecting the regulatory interplay between proteases and protein kinases in acute lymphoblastic leukemia using mass cyt...

Call: OPUS 24 , Panel: NZ5

Principal investigator: dr hab. Marcin Poręba

Politechnika Wrocławska

Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

Call: PRELUDIUM BIS 4 , Panel: NZ5

Principal investigator: prof. Ewa Marcinkowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Unraveling genes and mechanisms underlying relapse of T-cell acute lymphoblastic leukemia

Call: OPUS 24 , Panel: NZ5

Principal investigator: dr hab. Małgorzata Dawidowska

Instytut Genetyki Człowieka Polskiej Akademii Nauk

Mechanisms and consequences of CD19 loss in B-acute lymphoblastic leukaemia patients relapsing after CD19-CAR-T cell the...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Instytut Hematologii i Transfuzjologii

Assessment of SARS-CoV-2 infection in patients with chronic lymphocytic leukemia depending on indicators of immune disor...

Call: OPUS 21 , Panel: NZ6

Principal investigator: prof. Ewelina Grywalska

Uniwersytet Medyczny w Lublinie

Identification of mTOR pathway deregulation mechanisms alternative to mutations in T-cell acute lymphoblastic leukemia (...

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: Natalia Maćkowska-Maślak

Instytut Genetyki Człowieka Polskiej Akademii Nauk

Array-based genomic and transcriptomic profiling in pediatric acute myeloblastic leukemia in search of genes resposible ...

Call: SONATA 2 , Panel: NZ5

Principal investigator: dr Joanna Szczepanek

Uniwersytet Mikołaja Kopernika

Improving therapeutic efficacy of anti-CD20 antibodies in precursor B-cell acute lymphoblastic leukemia

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr Małgorzata Firczuk

Warszawski Uniwersytet Medyczny, Wydzial Lekarski

Identifying the hematopoietic and leukemic stem cell niches

Call: MOZART 1 , Panel: NZ3

Principal investigator: dr Krzysztof Szade

Uniwersytet Jagielloński

Epigenetic effect on therapeutic activities of all-trans-retinoic acid in acute myeloid leukemia

Call: OPUS 17 , Panel: NZ5

Principal investigator: prof. Arthur Zelent

Wojskowy Instytut Higieny i Epidemiologii im. gen. Karola Kaczkowskiego

Identifying and overcoming mechanisms promoting resistance to venetoclax in B cell acute lymphoblastic leukemia with MLL...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: dr Klaudyna Fidyt

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Deciphering molecular mechanism of CDK8 kinase inhibitors action in acute myeloid leukemia

Call: SONATA BIS 8 , Panel: NZ2

Principal investigator: dr hab. Michał Mikula

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

Tracing the roots of leukemia - how preleukemic hematopoietic stem cells contribute to acute lymphoid and myeloid leukem...

Call: HARMONIA 10 , Panel: NZ5

Principal investigator: dr Krzysztof Szade

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Determining the role of basigin in multiple myeloma and acute myeloid leukaemia development

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Piotr Łacina

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Effect of heterozygous mutations and radiaton on expression of DNA repair genes- MRE11, RAD50 and NBN in the cells of ac...

Call: OPUS 1 , Panel: NZ5

Principal investigator: prof. Jerzy Nowak

Instytut Genetyki Człowieka PAN

Identification of novel oncogenic/tumor suppressive miRNA-mRNA interactions in pathogenesis of pediatric T-cell acute ly...

Call: PRELUDIUM 13 , Panel: NZ2

Principal investigator: Monika Drobna-Śledzińska

Instytut Genetyki Człowieka Polskiej Akademii Nauk

Identification and targeting molecular drug resistance mechanisms in adult B-cell acute lymphoblastic leukemia

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Mediators of genetic instability in B-cell acute lymphoblastic leukemia (B-ALL)

Call: PRELUDIUM 10 , Panel: NZ5

Principal investigator: Karolina Karabin

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Products of DNA demethylation and deamination pathways as new biomarkers of development and predictors of the outcome in...

Call: OPUS 10 , Panel: NZ5

Principal investigator: dr hab. Daniel Gackowski

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy, Wydział Farmaceutyczny

DNA methylation and microRNA expression profiling in different types of cancer

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Izabela Zawlik

Uniwersytet Rzeszowski

Novel pro-oxidative strategies in the treatment of B cell acute lymphoblastic leukemia

Call: SONATA BIS 5 , Panel: NZ5

Principal investigator: dr Małgorzata Firczuk

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Genetic variability of transcription factor GATA3 in pathogenesis of acute limphoblastic leucemia (ALL)

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Joanna Madzio

Uniwersytet Medyczny w Łodzi, I Katedra Pediatrii

Cardiovascular micro RNA fingerprint of anthracyclines - study in vitro and in vivo in long-term acute lymphoblastic leu...

Call: SONATA 9 , Panel: NZ7

Principal investigator: dr Justyna Totoń-Żurańska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski