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Identifying and overcoming mechanisms promoting resistance to venetoclax in B cell acute lymphoblastic leukemia with MLL gene rearrangements

2018/31/N/NZ5/01438

Keywords:

venetoclax resistance B cell acute lymphoblastic leukemia MLL gene rearrangements

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Klaudyna Fidyt 

Number of co-investigators in the project: 3

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 209 440 PLN

Project start date (Y-m-d): 2019-07-05

Project end date (Y-m-d): 2022-07-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Potent, p53-independent induction of NOXA sensitizes MLL-rearranged B-cell acute lymphoblastic leukemia cells to venetoclax
    Authors:
    Klaudyna Fidyt, Agata Pastorczak, Julia Cyran, Nicholas T. Crump, Agnieszka Goral, Joanna Madzio, Angelika Muchowicz, Martyna Poprzeczko, Krzysztof Domka, Lukasz Komorowski, Magdalena Winiarska, Joe R. Harman, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Wojciech Mlynarski, Jakub Golab, Thomas A. Milne, Malgorzata Firczuk
    Academic press:
    Oncogene (rok: 2022, tom: 41, strony: 1600–1609), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41388-022-02196-y - link to the publication
  1. Pharmacological Induction of NOXA Sensitizes High-Risk B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax
    Authors:
    Klaudyna Fidyt, Julia Cyran, Agata Pastorczak, Nicholas T. Crump, Angelika Muchowicz, Agnieszka Goral, Krzysztof Domka, Lukasz Komorowski, Karolina Siudakowska, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Magdalena Winiarska, Jakub Golab, Thomas A. Milne, Malgorzata Firczuk
    Conference:
    62nd ASH Annual Meeting & Exposition (rok: 2020, ), Wydawca: Blood
    Data:
    konferencja 05.12.2020-08.12.2020
    Status:
    Published

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