Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Novel pro-oxidative strategies in the treatment of B cell acute lymphoblastic leukemia

2015/18/E/NZ5/00723

Keywords:

B cell acute lymphoblastic leukemia therapeutic targets antioxidant enzymes thioredoxin peroxiredoxin

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ3_3: Apoptosis
  • NZ4_11: Metabolism

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Firczuk 

Number of co-investigators in the project: 11

Call: SONATA BIS 5 - announced on 2015-06-15

Amount awarded: 1 588 300 PLN

Project start date (Y-m-d): 2016-04-21

Project end date (Y-m-d): 2021-08-20

Project duration:: 64 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z monitorem i podstawowym oprogramowaniem (2 szt.) (8 000 PLN)
  2. Mała wirówka z chłodzeniem (14 000 PLN)
  3. Oprogramowanie GraphPad Prism (3 000 PLN)
  4. Zbiornik do magazynowania w ciekłym azocie (30 000 PLN)
  5. Mikroskop Zeiss Primo Vert.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage-Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities
    Authors:
    Komorowski L, Fidyt K, Patkowska E, Firczuk M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 45321), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165776 - link to the publication
  2. Potent, p53-independent Induction of NOXA Sensitizes MLL-rearranged B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax
    Authors:
    Fidyt K, Pastorczak A, Cyran J, Crump NT, Goral A, Madzio J, Muchowicz A, Poprzeczko M, Domka K, Komorowski L, Winiarska M, Harman JR, Siudakowska K, Graczyk-Jarzynka A, Patkowska E, Lech-Maranda E, Mlynarski W, Golab J, Milne TA, and Firczuk M
    Academic press:
    Oncogene (rok: 2022, tom: 1, strony: 45301), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41388-022-02196-y - link to the publication
  3. Targeting the thioredoxin system as a novel strategy against B cell acute lymphoblastic leukemia
    Authors:
    Klaudyna Fidyt, Agata Pastorczak, Agnieszka Goral, Kacper Szczygiel, Wojciech Fendler, Angelika Muchowicz, Marcin Adam Bartlomiejczyk, Joanna Madzio, Julia Cyran, Agnieszka Graczyk-Jarzynka,Eugene Jansen, Elzbieta Patkowska, Ewa Lech-Maranda, Deepali Pal, Helen Blair, Anna Burdzinska, Piotr Pedzisz, Eliza Glodkowska-Mrowka, Urszula Demkow, Karolina Gawle-Krawczyk, Michal Matysiak,Magdalena Winiarska, Przemyslaw Juszczynski, Wojciech Mlynarski, Olaf Heidenreich, Jakub Golab, Malgorzata Firczuk
    Academic press:
    Molecular Oncology (rok: 2018, tom: 13, strony: 1180-1195), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/1878-0261.12476 - link to the publication
  4. New insights into redox homeostasis as a therapeutic target in B-cell malignancies
    Authors:
    Graczyk-Jarzynka A, Zagozdzon R, Muchowicz A, Siernicka M, Juszczynski P, Firczuk M
    Academic press:
    Curr Opin Hematol (rok: 2017, tom: 4, strony: 393-401), Wydawca: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/MOH.0000000000000351 - link to the publication
  1. Pharmacological Induction of NOXA Sensitizes High-Risk B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax
    Authors:
    Klaudyna Fidyt , Julia Cyran , Agata Pastorczak , Nicholas T. Crump , Angelika Muchowicz , Agnieszka Goral , Krzysztof Domka , Lukasz Komorowski , Karolina Siudakowska , Agnieszka Graczyk-Jarzynka , Elzbieta Patkowska , Magdalena Winiarska , Jakub Golab , Thomas A. Milne and Malgorzata Firczuk
    Conference:
    ASH (American Society of Hematology) ANNUAL MEETING (rok: 2020, ), Wydawca: ASH (American Society of Hematology)
    Data:
    konferencja 5-8 grudzień 2020
    Status:
    Published
  2. TARGETING THIOREDOXIN SYSTEM AS A NOVEL STRATEGY AGAINST B CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Authors:
    Klaudyna Fidyt, Agata Pastorczak, Kacper Szczygiel, Angelika Muchowicz, Agnieszka Goral, Joanna Madzio, Marcin Bartlomiejczyk, Eugene Jansen, Deepali Pal, Helen Blair, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Jakub Golab, Malgorzata Firczuk
    Conference:
    10th EFIS-EJI South Eastern European Immunology School (SEEIS2018) (rok: 2018, ), Wydawca: European Federation of Immunological Societies
    Data:
    konferencja 19-22 październik
    Status:
    Published

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