Projects funded by the NCN

Purinergic signaling as important regulator of hematopoietic system

Call: OPUS 15 , Panel: NZ4

Principal investigator: prof. Mariusz Ratajczak

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Abnormal metabotropic-nucleotide-receptors (P2Y) - dependent calcium response in myoblasts derived from mouse with mutat...

Call: OPUS 6 , Panel: NZ3

Principal investigator: prof. Krzysztof Zabłocki

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Metabolic profiles, gene polymorphism in NAT2, GSTM1, GSTP1, CYP1A1, COMT and epidemiological data in a holistic approac...

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: Emilia Daghir-Wojtkowiak

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

From a molecular in silico model to cellular response in vitro. Modified nucleosides as photo and/or radiosensitizers of...

Call: MAESTRO 6 , Panel: ST4

Principal investigator: prof. Janusz Rak

Uniwersytet Gdański, Wydział Chemii

The use of evolutionary patterns in the optimization of chemotherapy of tuberculosis

Call: SONATA BIS 9 , Panel: NZ6

Principal investigator: dr Alina Ewa Minias

Instytut Biologii Medycznej Polskiej Akademii Nauk

Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular bi...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Dagmara Baraniak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Jacek Stawiński

Instytut Chemii Bioorganicznej PAN

Chromatographic determination of nucleic acids (DNA, RNA) and their constituents (nucleosides, nucleotides, oligonuceoti...

Call: SONATA 1 , Panel: ST4

Principal investigator: dr Sylwia Studzińska

UNIWERSYTET MIKOŁAJA KOPERNIKA, Wydział Chemii, Katedra Chemii Środowiska i Bioanalityki

Genomics of hybridization, adaptive variation and demography in hybrid zones of closely related pine species (genus Pinu...

Call: OPUS 1 , Panel: NZ8

Principal investigator: dr hab. Witold Wachowiak

Instytut Dendrologii PAN

Effect of single nucleotide polymorphism (SNP) in the human chorionic gonadotropin beta subunit gene on its expression i...

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr Mirosław Andrusiewicz

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Nauk o Zdrowiu

Adenosine 5'-phosphoramidate as a novel signaling molecule; Study of enzymatic synthesis of this nucleotide and analysis...

Call: OPUS 3 , Panel: NZ1

Principal investigator: prof. Andrzej Guranowski

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa i Bioinżynierii

The impact of rs868 single nucleotide polymorphism on the outcome of liver transplantation in hepatitis C

Call: PRELUDIUM 3 , Panel: NZ6

Principal investigator: Emir Sajjad

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Genetic and epigenetic fundamentals of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: Tomasz Klepinowski

Pomorski Uniwersytet Medyczny w Szczecinie

The characteristic of fucose metabolism in mammalian cells

Call: PRELUDIUM 21 , Panel: NZ3

Principal investigator: Edyta Skurska

Uniwersytet Wrocławski, Wydział Biotechnologii

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Magdalena Materna

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Structural and mechanistic studies of bacterial DNA repair

Call: MAESTRO 9 , Panel: NZ1

Principal investigator: prof. Marcin Nowotny

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Błażej Wojtczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Analysis of cooperation of SLC35A3, SLC35B4 and SLC35D2 proteins in UDP-N-acetylglucosamine distribution in mammalian ce...

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: Bożena Szulc

Uniwersytet Wrocławski, Wydział Biotechnologii

Functional analysis of SLC35A transporter family - substrate specificity and ability to interact with other proteins in ...

Call: OPUS 8 , Panel: NZ3

Principal investigator: prof. Mariusz Olczak

Uniwersytet Wrocławski, Wydział Biotechnologii

Synthesis and evaluation of a novel toolkit for biology and biotechnology based on adenine nucleotides analogs

Call: SONATA BIS 5 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

Call: SONATA 11 , Panel: ST5

Principal investigator: dr Karolina Piecyk

Uniwersytet Warszawski, Wydział Chemii

Molecular bases of a therapy of rare genetic diseases caused by impaired activity of nucleotide sugar transporters

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Mariusz Olczak

Uniwersytet Wrocławski, Wydział Biotechnologii

Functional and structural relationship between nucleotide sugar biosynthesis and their transport to the subcellular comp...

Call: OPUS 26 , Panel: NZ3

Principal investigator: prof. Mariusz Olczak

Uniwersytet Wrocławski, Wydział Biotechnologii

Genomic analysis of invasive vancomycin-resistant Enterococcus faecium of VanA phenotype from intensive-care units in Po...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Ewa Wardal

Narodowy Instytut Leków

Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Antiviral activity of novel acyclic phosphonate nucleoside analogues containing the 1,2,3-triazole moiety

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr Iwona Głowacka

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

A new gereration of anticancer pronucleotides

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Jacek Stawiński

Instytut Chemii Bioorganicznej PAN

Pronucloetides - a pathway to cellular DNA sensitization to ionizing radiation

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Magdalena Zdrowowicz

Uniwersytet Gdański, Wydział Chemii

Synthesis and study of spectroscopic and bilogical properties of nucleosides modyfied by new stilbene derivatives

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Przemysław Szczeciński

Politechnika Warszawska, Wydział Chemiczny

Transformation of 5'-O-monothiophosphate nucleoside to 5'-O-monophosphate in the cell - possible metabolism of phosphoro...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr Agnieszka Krakowiak

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

Call: SONATA BIS 3 , Panel: NZ1

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

Call: OPUS 6 , Panel: ST5

Principal investigator: dr hab. Marzena Jankowska-Anyszka

Uniwersytet Warszawski, Wydział Chemii

Cellular and molecular mechanism of action of PPI dendrimer complexes with nucleoside analogue anticancer drugs

Call: OPUS 7 , Panel: NZ3

Principal investigator: prof. Barbara Klajnert-Maculewicz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Methods and algorithms of discovering novel phenomena in genomes and transcriptomes with the statistical analysis of nuc...

Call: PRELUDIUM 7 , Panel: ST6

Principal investigator: Marek Wiewiórka

Politechnika Warszawska, Wydział Elektroniki i Technik Informacyjnych

Look at the mechanism of ovarian cancer cells response to adenine nucleosides modified with metallacarborane clusters wi...

Call: OPUS 9 , Panel: NZ3

Principal investigator: dr Katarzyna Bednarska

Instytut Biologii Medycznej PAN

Fluorescent biosensors based on quantum dots and purines/pyrimidines - synthesis, characterization and potential applica...

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Łucja Rodzik-Czałka

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Anna Wojtczak

Uniwersytet Warszawski, Wydział Fizyki

Reversal of heart failure during mechanical support of left ventricular function - role of nucleotides and energetics in...

Call: HARMONIA 8 , Panel: NZ4

Principal investigator: dr hab. Ryszard Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

In search of novel functions for SLC35A2 protein

Call: SONATA 12 , Panel: NZ3

Principal investigator: dr Dorota Maszczak-Seneczko

Uniwersytet Wrocławski, Wydział Biotechnologii

Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyl...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Renata Kasprzyk

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Adaptations of cardiac myocyte energy metabolism in atherosclerosis - implications for pathology and therapeutic strateg...

Call: OPUS 12 , Panel: NZ4

Principal investigator: dr hab. Ryszard Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Magdalena Danuta Zdrowowicz-Żamojć

Uniwersytet Gdański, Wydział Chemii

Algorithms for processing nucleotide and aminoacid sequences

Call: OPUS 23 , Panel: ST6

Principal investigator: prof. Sebastian Tomasz Deorowicz

Politechnika Śląska, Wydział Automatyki, Elektroniki i Informatyki

Targeting enzymes of the parasite's purine salvage pathway as a new approach to combat H. pylori infections, including t...

Call: OPUS 26 , Panel: NZ1

Principal investigator: prof. Maria Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Małgorzata Artymowicz

Gdański Uniwersytet Medyczny, Wydział Farmacutyczny

Fotochemistry and Photophysics of Thiated Prebiotic Precursors of Nucleotides

Call: PRELUDIUM 17 , Panel: ST4

Principal investigator: dr Mikołaj Jan Janicki

Politechnika Wrocławska

mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics

Call: OPUS 17 , Panel: ST4

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Barbara Nawrot

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the in...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Michał Matuszewski

Politechnika Łódzka, Wydział Chemiczny

THE EFFECT OF NUCLEOSIDE ANALOGUES ON REPLICATION OF CYHV-3 (CYPRINID HERPESVIRUS 3) IN CELL LINES OF COMMON CARP (CYPRI...

Call: PRELUDIUM 7 , Panel: NZ6

Principal investigator: Agnieszka Troszok

Polska Akademia Nauk Zakład Ichtiobiologii i Gospodarki Rybackiej w Gołyszu