Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Abnormal metabotropic-nucleotide-receptors (P2Y) - dependent calcium response in myoblasts derived from mouse with mutated dystrophin encoding gene.

2013/11/B/NZ3/01573

Keywords:

muscular dystrophy metabotropic nucleotide receptors P2Y

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Zabłocki 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 1 077 200 PLN

Project start date (Y-m-d): 2014-07-11

Project end date (Y-m-d): 2018-07-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Sustained activation of P2X7 induces MMP-2-evoked cleavage and functional purinoceptor inhibition
    Authors:
    Young CNJ, Chira N, Róg J, Al-Khalidi R, Benard M, Galas L, Chan P, Vaudry D, Zabłocki K, Górecki DC.
    Academic press:
    Journal of Molecular Cell Biology (rok: 2017, tom: 1, strony: 45305), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.006. - link to the publication
  2. Dystrophic mdx mouse myoblasts exhibit elevated ATP/UTP-evoked metabotropic purinergic responses and alterations in calcium signalling
    Authors:
    Justyna Róg, Aleksandra Oksiejuk, Maxime Gosselin, Wojciech Brutkowski, Dorota Dymkowska, Natalia Nowak, Samuel Robson, Dariusz C. Górecki, Krzysztof Zabłocki1
    Academic press:
    Biochimica et Biophisica Acta - Molecular Basis of Disease (rok: 2019, tom: 1865, strony: 1138-1151), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2019.01.002. - link to the publication
  3. Metabotropic purinergic receptor profiles and calcium signalling in primary mice myoblasts differ depending on their muscle origin and are altered in cells with mutated dystrophin gene (mdx mice)
    Authors:
    Justyna Róg, Aleksandra Oksiejuk, Dariusz C. Górecki, Krzysztof Zabłocki
    Academic press:
    bioRxiv preprint (rok: 2022, tom: ----------, strony: -----------), Wydawca: Cold Spring Harbor Laboratory
    Status:
    Submitted
    DOI:
    10.1101/2022.02.16.478175 - link to the publication
  4. Disrupted Calcium Homeostasis in Duchenne Muscular Dystrophy: A Common Mechanism behind Diverse Consequences
    Authors:
    Zabłocka, B. Górecki, D.C. Zabłocki, K.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 45312), Wydawca: MDPI Multidisciplinary Digital Publishing Institute
    Status:
    Published
    DOI:
    10.3390/ijms222011040. - link to the publication
  5. Zidovudine ameliorates pathology in the mouse model of Duchenne muscular dystrophy via P2RX7 purinoceptor antagonism. Acta Neuropathologica Communications
    Authors:
    Al-Khalidi R, Chiara Panicucci C, Cox P, Chira N, Róg J, Young CNJ, McGeehan RE, Ambati K, Ambati J, Zabłocki K, Gazzerro E, Arkle S, Bruno C, Górecki DC
    Academic press:
    Acta Neuropathologica Communications (rok: 2018, tom: 6, strony: 45308), Wydawca: Biomed Central
    Status:
    Published
    DOI:
    10.1186/s40478-018-0530-4 - link to the publication

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