Projects funded by the NCN

Targeted inhibition of STATs and IRFs as a novel treatment strategy in cardiovascular disease

Call: OPUS 9 , Panel: NZ2

Principal investigator: prof. Johannes Bluijssen (Bluyssen)

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

DNA repair pathways contributing to resistance to photodynamic therapy and as possible theraupeutic targets

Call: OPUS 8 , Panel: NZ5

Principal investigator: dr hab. Elżbieta Speina

Instytut Biochemii i Biofizyki PAN

Functional Characterization of Non-Collagenous Extracellular Matrix Proteins as a Potential Molecular Target and Novel B...

Call: SONATA 8 , Panel: NZ5

Principal investigator: dr Michał Pawlak

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Identification of new, clinically relevant genetic and epigenetic aberrations by next-generation sequencing in chronic m...

Call: HARMONIA 6 , Panel: NZ5

Principal investigator: dr Tomasz Stokłosa

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Analysis of relations on the level of metabolome, miRNome, and transcriptome of human renal cancer: towards identificati...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Piekiełko-Witkowska

Centrum Medyczne Kształcenia Podyplomowego

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Disorders of metabolic pathways in breast cancer cells in population of postmenopausal women

Call: PRELUDIUM 5 , Panel: NZ5

Principal investigator: Łukasz Kwinta

Wielkopolskie Centrum Onkologii

Targeted genomics of cardiovascular disease - multivariable genetic model of perioperative and long-term cardiovascular ...

Call: OPUS 5 , Panel: NZ5

Principal investigator: prof. Marek Sanak

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

Non-targeted metabolite fingerprinting of biological sample using gas chromatography with mass spectrometry detector

Call: PRELUDIUM 4 , Panel: NZ5

Principal investigator: Arlette Yumba Mpanga

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Identification of triple negative breast cancer with inactive DNA damage repair pathway by homologous recombination base...

Call: SONATA 3 , Panel: NZ5

Principal investigator: dr Paweł Domagała

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

Targeted DNA Capture and Next Generation Sequencing to identify mutations responsible for hearing impairment

Call: SONATA 2 , Panel: NZ5

Principal investigator: dr Agnieszka Pollak

Instytut Fizjologii i Patologii Słuchu

Modulation of protein interaction networks as a new therapeutic target in the treatment of hereditary retinal dystrophie...

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Xiaonan Liu

Śląski Uniwersytet Medyczny w Katowicach, Wydział Nauk Medycznych w Katowicach

Curdlan-based biomaterial as a nanostructure carrier for controlled and targeted drug delivery in the treatment of deep ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Aleksandra Nurzyńska

Uniwersytet Medyczny w Lublinie

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Alicja Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

Call: PRELUDIUM BIS 4 , Panel: NZ5

Principal investigator: prof. Ewa Marcinkowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Molecular insights into hypoxic tumors – for development of targeted cancer therapeutics

Call: POLONEZ BIS 3 , Panel: NZ5

Principal investigator: dr Marco Deiana

Politechnika Wrocławska

Modifiers of Muscleblind-like genes expression in health and disease.

Call: SONATA BIS 12 , Panel: NZ5

Principal investigator: dr hab. Ewa Stępniak-Konieczna

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

A smart stride for cancer: synergistic effect of co-delivery chemo- andphototherapeutic agents using magneto-fluorescent...

Call: POLONEZ BIS 2 , Panel: NZ7

Principal investigator: dr Prachi Ghoderao

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Daniel

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Targeting of metabolic and transcriptomic cross-talk between leukemic cells and macrophages as a therapeutic strategy in...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Baran Natalia

Instytut Hematologii i Transfuzjologii

Perinuclear AKAP6 signalosome as a new target for gene therapy in ischemic optic neuropathy

Call: OPUS 22 , Panel: NZ4

Principal investigator: dr hab. Tomasz Boczek

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Interleukin-18 receptor targeted gene therapy as a novel approach for the treatment of pulmonary hypertension using cont...

Call: POLONEZ BIS 1 , Panel: NZ5

Principal investigator: dr Tara Scott

Gdański Uniwersytet Medyczny, Wydział Lekarski

The role of NPM1 as biomarker of the targeted therapy efficacy in chronic lymphocytic leukemia patients

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Krzysztof Giannopoulos

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr Maciej Szydłowski

Instytut Hematologii i Transfuzjologii

In the search of specific oxylipin fingerprint reflecting the development of endothelial dysfunction with the use of non...

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Agnieszka Kij

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Florczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Chronic pain in obesity: from cellular mechanisms to new strategies for targeted therapy.

Call: SONATA 17 , Panel: NZ5

Principal investigator: dr Anna Piotrowska-Murzyn

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Proline metabolism as a novel therapeutic target for diseases associated with mitochondrial dysfunction.

Call: SONATA BIS 11 , Panel: NZ3

Principal investigator: dr Karolina Szczepanowska

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

ATHENA Study - ArTerial HypErtension PAthogenesis - microRNA as a missing link of the disease development in children.

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: Michał Szyszka

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Shaoshan Mai

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Molecular and cellular landscape of pulmonary and hepatic metastases of colorectal cancer with potential clinical implic...

Call: PRELUDIUM 20 , Panel: NZ4

Principal investigator: Marta Popęda

Gdański Uniwersytet Medyczny, Wydział Lekarski

Identification of the interdependence between SWI/SNF-type chromatin remodeling complex, metabolism control and RNA modi...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr hab. Tomasz Sarnowski

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

The use of surface proteins to capture cancer cells with functionalized magnetic nanoparticles as an innovative theranos...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr hab. Joanna Dulińska-Litewka

Uniwersytet Jagielloński, Collegium Medicum

Identification of potential markers aiming early diagnostics of progression and tailoring metastasis-oriented therapies ...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Natalia Bednarz-Knoll

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Targeted degradation of Rab geranylgeranyl transferase as a new approach to investigate prenylation of Rab GTPases

Call: PRELUDIUM BIS 2 , Panel: NZ1

Principal investigator: dr hab. Edyta Gendaszewska-Darmach

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

The significance of circadian rhythm in urinary bladder cancer: deregulation of circadian genes as a putative therapeuti...

Call: OPUS 19 , Panel: NZ5

Principal investigator: prof. Edyta Reszka

Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Understanding of the mesenchymal stem cells (MSCs)-mediated immune suppression mechanism in the neutrophilic experimenta...

Call: PRELUDIUM 19 , Panel: NZ5

Principal investigator: Marlena Tynecka

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

Dynamina-2 jako potencjalny cel terapeutyczny w chłoniaku rozlanym z dużych komórek B

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

New insights into multifaceted targeted therapy for treatment of glioblastoma multiforme.

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr Katarzyna Malarz

Uniwersytet Śląski w Katowicach, Wydział Nauk Ścisłych i Technicznych

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Kuter

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The 'omics' of renal cancer nucleolus: towards identification of new cancer markers and therapeutic targets.

Call: OPUS 18 , Panel: NZ5

Principal investigator: prof. Agnieszka Piekiełko-Witkowska

Centrum Medyczne Kształcenia Podyplomowego, Studium Kliniczno-Dydaktyczne

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

The effect of Hmmr gene and its interaction with the endogenous opioid system as a novel mechanism and a therapeutic tar...

Call: SONATA 15 , Panel: NZ5

Principal investigator: dr Dominik Skiba

Instytut Genetyki i Hodowli Zwierząt Polskiej Akademii Nauk

Synthesis and biofunctionalization of boron-rich nanoparticles; the application in targeted boron neutron capture therap...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Elżbieta Pajtasz-Piasecka

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Definition of targetable signaling pathways in chronic lymphocytic leukemia patients with rationale to novel therapy wit...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Joanna Knap-Stępień

Uniwersytet Medyczny w Lublinie, Wydział Lekarski

Multi-level molecular assessment based on laser microdissection of corneas to reveal biomarkers and therapeutic targets ...

Call: OPUS 16 , Panel: NZ5

Principal investigator: prof. Marzena Gajęcka

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny