Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of MCPIP1 as a potential tumor suppressor during development and treatment of clear cell renal cell carcinoma

2017/25/N/NZ5/03014

Keywords:

MCPIP1 clear cell renal cell carcinoma tumor initiation targeted therapies c-Met receptor

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_1: Etiology of human diseases
  • NZ3_1: Cell biology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paulina Marona 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 120 000 PLN

Project start date (Y-m-d): 2018-02-07

Project end date (Y-m-d): 2022-02-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Oprogramowanie (4 600 PLN)
  2. Komputer stacjonarny All-In-One wraz z oprogramowaniem (4 900 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. Resistance to tyrosine kinase inhibitors promotes renal cancer progression through MCPIP1 tumor-suppressor downregulation and c-Met activation
    Authors:
    Paulina Marona, Judyta Górka, Oliwia Kwapisz, Jolanta Jura, Janusz Rys, Robert M Hoffman, Katarzyna Miekus
    Academic press:
    Cell Death and Disease (rok: 2022, tom: 13, strony: 814), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41419-022-05251-4 - link to the publication
  1. Clear cell renal cell carcinoma resistance to RTKs inhibitors is mediated by c-Met receptor and MCPIP1
    Authors:
    Paulina Marona, Judyta Górka, Jolanta Jura, Katarzyna Miękus
    Conference:
    Annual Meeting of the American-Association-for-Cancer-Research (AACR) (rok: 2018, ), Wydawca: Cancer Research AACR
    Data:
    konferencja 14-18 kwietnia 2018
    Status:
    Published

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