Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Hypoxia compensation into physioxia to normalize/regenerate ischaemc tissues. Effects of microRNA regulation for targeted stable vessel normalisation in tumor treatments.

2016/23/B/NZ1/03211

Keywords:

endothelial cells hypoxia vessel normalization microRNA

Descriptors:

  • NZ1_7: Cell engineering
  • NZ1_9: Biotechnology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Wojskowy Instytut Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Claudine Kieda 

Number of co-investigators in the project: 7

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 553 100 PLN

Project start date (Y-m-d): 2017-10-20

Project end date (Y-m-d): 2021-10-19

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Regał z klatkami do przechowywania zwierząt (2 szt.) (34 000 PLN)
  2. Stacja wymiany klatek (60 000 PLN)
  3. Zestaw do Western Blottingu.
  4. Odwrócony mikroskop fluorescencyjny.
  5. Indywidualnie wentulowany regał do przechowywania zwierząt (135 000 PLN)
  6. Komora do pracy w kontrolowanych warunkach pO2 (165 000 PLN)
  7. Chłodziarko-zamrażarka (3 szt.).
  8. Chłodziarka z powietrzem obiegowym.
  9. Komputer stacjonarny (2 szt.) (6 000 PLN)
  10. Lodówka.

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (1)
  1. Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies
    Authors:
    Abou Khouzam, R. Brodaczewska, K. Filipiak, A. Zeinelabdin, N. A. Buart, S. Szczylik, C. Kieda, C. Chouaib, S.
    Academic press:
    Frontiers in Immunology (rok: 2021, tom: 11, strony: 45307), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.613114 - link to the publication
  2. miRNA Pattern in Hypoxic Microenvironment of Kidney Cancer—Role of PTEN
    Authors:
    Aleksandra Majewska, Klaudia Brodaczewska, Aleksandra Filipiak-Duliban, Arkadiusz Kajdasz, Claudine Kieda
    Academic press:
    Biomolecules (rok: 2022, tom: 12, 686, strony: 45313), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12050686 - link to the publication
  3. Spheroid culture differentially affects cancer cell sensitivity to drugs in melanoma and RCC models.
    Authors:
    Aleksandra Filipiak-Duliban, Klaudia Brodaczewska, Arkadiusz Kajdasz, Claudine Kieda
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23(3), 1166, strony: 45304), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031166 - link to the publication
  4. Spheroid culture models adequately imitate distinctive features of the renal cancer or melanoma microenvironment
    Authors:
    Filipiak-Duliban Aleksandra, Brodaczewska Klaudia, Majewska Aleksandra, Kieda Claudine
    Academic press:
    In Vitro Cellular & Developmental Biology - Animal (rok: 2022, tom: 58, strony: 349–364), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11626-022-00685-8 - link to the publication
  5. Distinctive Properties of Endothelial Cells from Tumor and Normal Tissue in Human Breast Cancer
    Authors:
    Wilkus, K. Brodaczewska, K. Kajdasz, A. Kieda, C.
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 30), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22168862 - link to the publication
  6. Endothelial Cells as Tools to Model Tissue Microenvironment in Hypoxia-Dependent Pathologies
    Authors:
    Majewska, A. Wilkus, K. Brodaczewska, K. Kieda, C
    Academic press:
    Inernational Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 25), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22020520 - link to the publication
  7. Tumour angiogenesis normalized by myo- inositol trispyrophosphate alleviates hypoxia in the microenvironment and promotes antitumor immune response
    Authors:
    El Hafny-Rahbi, B. Brodaczewska, K. Collet, G. Majewska, A. Klimkiewicz, K. Delalande, A. Grillon, C. Kieda, C.
    Academic press:
    Journal of cellular and Molecular Medicine (rok: 2021, tom: 25, strony: 3284-3299), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jcmm.16399 - link to the publication
  8. Hypoxia-Mediated Decrease of Ovarian Cancer Cells Reaction to Treatment: Significance for Chemo- and Immunotherapies
    Authors:
    Aleksandra Klemba, Lubomir Bodnar, Halina Was, Klaudia K. Brodaczewska, Gabriel Wcislo, Cezary A. Szczylik, Claudine Kieda
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21(24), 9492, strony: 45322), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21249492 - link to the publication
  1. Targeting cancer PTEN for hypoxia-related tumor microenvironment
    Authors:
    Aleksandra Majewska, Klaudia Brodaczewska, Claudine Kieda
    Conference:
    10th ANNIVERSARY INTERNATIONAL CONFERENCE OF CONTEMPORARY ONCOLOGY (rok: 2018, ), Wydawca: Termedia
    Data:
    konferencja 21–23 March 2018
    Status:
    Published

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