Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Co-dependence of cell-to-cell metabolite shuttles and macromolecular organization of metabolism in norm and pathology. Quantitative, qualitative and functional description of new targets for pharmacological treatment of lung cancer and heart and brain deseases.

2015/19/B/NZ1/00332

Keywords:

glycolysis lactate cancer CAFs neurons astrocytes heart quantitative proteomics

Descriptors:

  • NZ4_11: Metabolism
  • NZ3_2: Cell physiology
  • NZ1_2: Biochemistry

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Dariusz Rakus 

Number of co-investigators in the project: 12

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 440 000 PLN

Project start date (Y-m-d): 2016-06-28

Project end date (Y-m-d): 2019-12-27

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  1. Neuron-derived transthyretin modulates astrocytic glycolysis in hormone-independent manner
    Authors:
    Alina Zawislak, Piotr Jakimowicz, James A. McCubrey, Dariusz Rakus
    Academic press:
    Oncotarget (rok: 2017, tom: Vol. 8 (No. 63), strony: 106625-106638), Wydawca: Impact Journals, LCC
    Status:
    Published
    DOI:
    10.18632/oncotarget.22542 - link to the publication
  2. The Reverse Warburg Effect is Associated with Fbp2-Dependent Hif1α Regulation in Cancer Cells Stimulated by Fibroblasts.
    Authors:
    Duda P, Janczara J, McCubrey JA, Gizak A, Rakus D.
    Academic press:
    Cells (rok: 2020, tom: 9, strony: E205), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9010205 - link to the publication
  3. Expression of Fbp2, a Newly Discovered Constituent of Memory Formation Mechanisms, Is Regulated by Astrocyte–Neuron Crosstalk
    Authors:
    Hajka D, Duda P, Wójcicka O, Drulis-Fajdasz D, Rakus D, Gizak A
    Academic press:
    IJMS (rok: 2020, tom: 21, strony: 6903), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21186903 - link to the publication
  4. Targeting a moonlighting function of aldolase induces apoptosis in cancer cells.
    Authors:
    Gizak A, Wiśniewski J, Heron P, Mamczur P, Sygusch J, Rakus D.
    Academic press:
    Cell Death and Disease (rok: 2019, tom: 10, strony: 712), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41419-019-1968-4 - link to the publication
  5. Global quantitative TPA-based proteomics of mouse brain structures reveals significant alterations in expression of proteins involved in neuronal plasticity during aging.
    Authors:
    Duda P, Wójcicka O, Wiśniewski JR, Rakus D.
    Academic press:
    Aging (Alabany NY) (rok: 2018, tom: 10(7), strony: 1682-1697), Wydawca: Impact Journal, LCC
    Status:
    Published
    DOI:
    10.18632/aging.101501 - link to the publication
  6. Systematic analysis of GSK-3 signaling pathways in aging of cerebral tissue.
    Authors:
    Drulis-Fajdasz D, Rakus D, Wiśniewski JR, McCubrey JA, Gizak A.
    Academic press:
    Advances in Biological Regulation (rok: 2018, tom: 69, strony: 35-42), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jbior.2018.06.001 - link to the publication
  7. A novel remitting leukodystrophy associated with a variant in FBP2
    Authors:
    Gizak A, Diegmann S, Dreha-Kulaczewski S, Wisniewski J, Duda P, Ohlenbusch A, Huppke B, Henneke M, Hohne W, Altmuller J, Thiele H, Nurnberg P, Rakus D, Gartner J and Huppke P
    Academic press:
    Brain Commun. (rok: 2021, tom: 3(2): fcab036, strony: 45306), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/braincomms/fcab036 - link to the publication
  8. Aging-associated changes in hippocampal glycogen metabolism in mice. Evidence for and against astrocyte-to-neuron lactate shuttle.
    Authors:
    Drulis-Fajdasz D, Gizak A, Wójtowicz T, Wiśniewski JR, Rakus D
    Academic press:
    Glia (rok: 2018, tom: 66(7), strony: 1481-1495), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/glia.23319. - link to the publication
  9. Cell-to-cell lactate shuttle operates in heart and is important in age-related heart failure.
    Authors:
    Gizak A, McCubrey JA, Rakus D.
    Academic press:
    Aging (rok: 2020, tom: 12, strony: 0), Wydawca: Impact Journal, LCC
    Status:
    Published
    DOI:
    10.18632/aging.102818 - link to the publication
  10. Fructose 1,6-Bisphosphatase 2 Plays a Crucial Role in the Induction and Maintenance of Long-Term Potentiation
    Authors:
    Duda P., Wójtowicz T, Janczara J., Krowarsch D, Czyrek A., Gizak A.and Rakus D
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1375), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9061375 - link to the publication

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