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Novel pro-oxidative strategies in the treatment of B cell acute lymphoblastic leukemia

2015/18/E/NZ5/00723

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ3_3: Apoptoza
  • NZ4_11: Metabolizm

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Małgorzata Firczuk

Number of co-investigators in the project: 11

Call

SONATA BIS 5 – announced on 2015-06-15

Amount awarded
1 588 300 PLN
Project start date
2016-04-21
Project end date
2021-08-20
Project duration
64 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer z monitorem i podstawowym oprogramowaniem (2 pcs). Cost: 8 000 PLN
  2. Mała wirówka z chłodzeniem. Cost: 14 000 PLN
  3. Mikroskop Zeiss Primo Vert.
  4. Oprogramowanie GraphPad Prism. Cost: 3 000 PLN
  5. Zbiornik do magazynowania w ciekłym azocie. Cost: 30 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Philadelphia Chromosome-Positive Leukemia in the Lymphoid Lineage-Similarities and Differences with the Myeloid Lineage and Specific Vulnerabilities

    Authors:
    Komorowski L, Fidyt K, Patkowska E, Firczuk M.
    Academic press:
    International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 46052), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21165776 – link to the publication

  2. Potent, p53-independent Induction of NOXA Sensitizes MLL-rearranged B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax

    Authors:
    Fidyt K, Pastorczak A, Cyran J, Crump NT, Goral A, Madzio J, Muchowicz A, Poprzeczko M, Domka K, Komorowski L, Winiarska M, Harman JR, Siudakowska K, Graczyk-Jarzynka A, Patkowska E, Lech-Maranda E, Mlynarski W, Golab J, Milne TA, and Firczuk M
    Academic press:
    Oncogene (year: 2022, volume: 1, pages: 46032), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41388-022-02196-y – link to the publication

  3. New insights into redox homeostasis as a therapeutic target in B-cell malignancies

    Authors:
    Graczyk-Jarzynka A, Zagozdzon R, Muchowicz A, Siernicka M, Juszczynski P, Firczuk M
    Academic press:
    Curr Opin Hematol (year: 2017, volume: 4, pages: 393-401), Publisher: Wolters Kluwer
    Status:
    Published
    DOI:
    10.1097/MOH.0000000000000351 – link to the publication

  4. Targeting the thioredoxin system as a novel strategy against B cell acute lymphoblastic leukemia

    Authors:
    Klaudyna Fidyt, Agata Pastorczak, Agnieszka Goral, Kacper Szczygiel, Wojciech Fendler, Angelika Muchowicz, Marcin Adam Bartlomiejczyk, Joanna Madzio, Julia Cyran, Agnieszka Graczyk-Jarzynka,Eugene Jansen, Elzbieta Patkowska, Ewa Lech-Maranda, Deepali Pal, Helen Blair, Anna Burdzinska, Piotr Pedzisz, Eliza Glodkowska-Mrowka, Urszula Demkow, Karolina Gawle-Krawczyk, Michal Matysiak,Magdalena Winiarska, Przemyslaw Juszczynski, Wojciech Mlynarski, Olaf Heidenreich, Jakub Golab, Malgorzata Firczuk
    Academic press:
    Molecular Oncology (year: 2018, volume: 13, pages: 1180-1195), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/1878-0261.12476 – link to the publication

Articles in post-conference publications (2)

  1. Pharmacological Induction of NOXA Sensitizes High-Risk B Cell Acute Lymphoblastic Leukemia Cells to Venetoclax

    Authors:
    Klaudyna Fidyt , Julia Cyran , Agata Pastorczak , Nicholas T. Crump , Angelika Muchowicz , Agnieszka Goral , Krzysztof Domka , Lukasz Komorowski , Karolina Siudakowska , Agnieszka Graczyk-Jarzynka , Elzbieta Patkowska , Magdalena Winiarska , Jakub Golab , Thomas A. Milne and Malgorzata Firczuk
    Conference:
    ASH (American Society of Hematology) ANNUAL MEETING (year: 2020, pages: 1), Publisher: ASH (American Society of Hematology)
    Date:
    conference 5-8 grudzień 2020
    Status:
    Published

  2. TARGETING THIOREDOXIN SYSTEM AS A NOVEL STRATEGY AGAINST B CELL ACUTE LYMPHOBLASTIC LEUKEMIA

    Authors:
    Klaudyna Fidyt, Agata Pastorczak, Kacper Szczygiel, Angelika Muchowicz, Agnieszka Goral, Joanna Madzio, Marcin Bartlomiejczyk, Eugene Jansen, Deepali Pal, Helen Blair, Agnieszka Graczyk-Jarzynka, Elzbieta Patkowska, Ewa Lech-Maranda, Jakub Golab, Malgorzata Firczuk
    Conference:
    10th EFIS-EJI South Eastern European Immunology School (SEEIS2018) (year: 2018, pages: brak), Publisher: European Federation of Immunological Societies
    Date:
    conference 19-22 październik
    Status:
    Published

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