Projects funded by the NCN

Nanospectroscopic imaging of native biological membranes: Is the cell membrane the key for understanding the mechanism o...

Call: SONATA BIS 11 , Panel: ST4

Principal investigator: dr Katarzyna Pogoda

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego PAN

Molecular and functional characterisation of clubroot disease resistance mechanisms in Arabidopsis

Call: OPUS 21 , Panel: NZ9

Principal investigator: dr William Matthew Donald Truman

Instytut Genetyki Roślin PAN

Analysis of semaphorin 3 (SEMA3), protocadherin 9 (PCDH9) and S 100 calcium binding proteinA3 (S100A3) expression in pro...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Radosław Januchowski

Uniwersytet Zielonogórski, Collegium Medicum

Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D and 3D model of Head and Neck Squamous Cel...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: dr Joanna Elżbieta Kałafut

Uniwersytet Medyczny w Lublinie

Elucidation of the role of miR-7-5p in modulating of multidrug resistance in glioblastoma cells.

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: dr Ewa Lucyna Gajda

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Verification of personalized therapeutic strategy based on Integrated Stress Response inhibition for myeloid neoplasms w...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Piwocka

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Reversible senescence as a new mechanism of cancer cell resistance for chemotherapy. Analysis of the mechanism of cancer...

Call: SONATINA 5 , Panel: NZ3

Principal investigator: dr Karolina Anna Staniak

Politechnika Warszawska, Wydział Chemiczny

The role of vitamin D receptor in 5-fluorouracil responsiveness of colorectal cancer cells

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Magdalena - Milczarek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Marcin Wróbel

Uniwersytet Medyczny w Lublinie

Array-based genomic and transcriptomic profiling in pediatric acute myeloblastic leukemia in search of genes resposible ...

Call: SONATA 2 , Panel: NZ5

Principal investigator: dr Joanna Szczepanek

Uniwersytet Mikołaja Kopernika

Research on the influence of self-healing, organic-inorganic sol-gel layers on the corrosion resistance and fatigue of s...

Call: OPUS 20 (LAP) , Panel: ST5

Principal investigator: dr Justyna Krzak

Politechnika Wrocławska

Study on genetic, epigenetic, transcriptomic and proteomic mechanisms modulating sheep resistance to small ruminant lent...

Call: OPUS 20 (LAP) , Panel: NZ9

Principal investigator: dr hab. Ewa Joanna Grochowska

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Histological and structural remodeling of mitral valve chordae tendineae and the traction resistance in aspect of the pr...

Call: PRELUDIUM BIS 2 , Panel: NZ5

Principal investigator: prof. Agnieszka - Noszczyk-Nowak

Uniwersytet Przyrodniczy we Wrocławiu

Changes in lipid metabolism of resistant to BRAF/MEK inhibitors human melanoma cells associated with the presence of adi...

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Aleksandra Simiczyjew

Uniwersytet Wrocławski, Wydział Biotechnologii

Zinc deficient diet as a trigger for treatment-resistant depression in chronically stressed mice. Understanding the mech...

Call: OPUS 19 , Panel: NZ5

Principal investigator: dr hab. Bernadeta Szewczyk

Instytut Farmakologii PAN

Mechanism of acquiring resistance to polyenes on the Malassezia pachydermatis model

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Urszula Czyżewska

Uniwersytet w Białymstoku, Wydział Biologii

Investigation of molecular mechanisms of rapid antidepressant action of NLX-101, a biased agonist of the 5-HT1A receptor...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

The significance of mitochondrial DNA damage and reapir in occurance of insulin resistance in nonalcoholic fatty liver d...

Call: PRELUDIUM BIS 1 , Panel: NZ5

Principal investigator: prof. Janusz Zbigniew Szemraj

Uniwersytet Medyczny w Łodzi, Wydział Nauk o Zdrowiu

Analysis of bacteriophage P1 lytic functions as a way to discover the mechanisms of wide dissemination of clinical bacte...

Call: PRELUDIUM 18 , Panel: NZ6

Principal investigator: Agnieszka Bednarek

Instytut Biochemii i Biofizyki PAN

Investigation of the effectiveness and mechanisms of fungicidal activity of selected 1,3,4-thiadiazoles derivatives in i...

Call: OPUS 18 , Panel: NZ7

Principal investigator: prof. Mariusz Gagoś

Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

Galactosylceramide as a regulator of apoptotic gene expression and modulator of drug resistance in breast cancer cells.

Call: OPUS 18 , Panel: NZ5

Principal investigator: prof. Maciej Ugorski

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Medycyny Weterynaryjnej

Gankyrin protein as a new potential therapeutic target in multiple myeloma

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Irena Misiewicz-Krzemińska

Instytut Hematologii i Transfuzjologii

Elucidation of the mechanism of fat-induced liver insulin resistance

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Agnieszka Urszula Błachnio-Zabielska

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

Potential function of visfatin/NAMPT in the anoikis resistance of human ovarian cancer: novel insight into obesity-reala...

Call: PRELUDIUM 17 , Panel: NZ5

Principal investigator: dr Justyna Karolina Gogola-Mruk

Uniwersytet Jagielloński, Wydział Biologii

Determination of the mechanisms and possibility of central nervous system regeneration using mesenchymal stem cells and ...

Call: OPUS 16 , Panel: NZ3

Principal investigator: prof. Marcin Marek Majka

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Identifying and overcoming mechanisms promoting resistance to venetoclax in B cell acute lymphoblastic leukemia with MLL...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: dr Klaudyna Paulina Fidyt

Warszawski Uniwersytet Medyczny, Wydział Lekarski

The significance of cancer specific PFK-II (PFKFB3 and PFKFB4) isoenzymes inhibition in overcoming resistance to BRAF in...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Sonia Elżbieta Trojan

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

The combination of radiotherapy with imiquimod and sunitinib as a new therapeutic strategy overcoming some of the tumor ...

Call: SONATA 14 , Panel: NZ5

Principal investigator: dr Magdalena Jarosz-Biej

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Dissecting of the novel mechanisms in multi-drug resistance associated with vault's proteins and translation initiation ...

Call: SONATA BIS 8 , Panel: NZ7

Principal investigator: dr hab. Witold Szaflarski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Association of TXNDC5 and calreticulin with decreased ER stress, allowing resistant multiple myeloma cells to by-pass pr...

Call: PRELUDIUM 15 , Panel: NZ5

Principal investigator: Tadeusz Franciszek Kubicki

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski

Determination of mechanisms and critical molecular partners controlling the multidrug resistance proteins (P-gp and BCRP...

Call: OPUS 15 , Panel: NZ3

Principal investigator: dr hab. Marlena Godlewska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO, Studium Kliniczno-Dydaktyczne

Genomic insights into the mechanisms of drug resistance, virulence and transmission of Mycobacterium tuberculosis strain...

Call: DAINA 1 , Panel: NZ6

Principal investigator: dr Tomasz Jagielski

Uniwersytet Warszawski, Wydział Biologii

Regulation of epithelial to mesenchymal transition and therapy resistance to antitumor therapies by MCPIP1

Call: SONATA BIS 7 , Panel: NZ5

Principal investigator: dr hab. Katarzyna Miękus

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Mechanisms underlying insulin resistance in patients with pulmonary arterial hypertension. The role of peroxisome prolif...

Call: SONATA BIS 7 , Panel: NZ5

Principal investigator: dr hab. Grzegorz Kopeć

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Study on the use of primary cultures and established cell lines of canine lymphoma in the diagnosis and treatment of lym...

Call: PRELUDIUM 1 , Panel: NZ5

Principal investigator: Aleksandra Pawlak

Uniwersytet Przyrodniczy we Wrocławiu

Proteomic analysis of myeloma plasma cells to determine proteins and pathways involved in acquired resistance to proteas...

Call: OPUS 13 , Panel: NZ5

Principal investigator: dr Dominik Dytfeld

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Lekarski II

Evaluation of anticancer properties and molecular mechanisms of action of new hybrid molecules containing uracil skeleto...

Call: PRELUDIUM 13 , Panel: NZ3

Principal investigator: dr Angelika Agata Długosz-Pokorska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial p...

Call: OPUS 13 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Zinc Deficiency: An essential Variable for the Induction od Resistance to Antidepressants

Call: PRELUDIUM 13 , Panel: NZ5

Principal investigator: dr Anna Maria Rafało-Ulińska

Instytut Farmakologii PAN

Effectiveness of the mechanism regulating the aluminium resistance of wheat under soil drought stress.

Call: PRELUDIUM 13 , Panel: NZ9

Principal investigator: Joanna Siecińska

Instytut Agrofizyki im. Bohdana Dobrzańskiego PAN

Mechanisms mediating the induction of Growth hormone resistance in response to immune stress.

Call: PRELUDIUM 13 , Panel: NZ9

Principal investigator: Maciej Wójcik

Instytut Fizjologii i Żywienia Zwierząt im. Jana Kielanowskiego PAN

CBR1-dependent metabolism and ABCB1-dependent effux of doxorubicin - search for a novel mechanism of reversing resistanc...

Call: PRELUDIUM 13 , Panel: NZ7

Principal investigator: Kamil Tomasz Piska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Evaluation of primary and secondary molecular disorders determinig drug resistance from a group of proteasome inhibitors...

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Tadeusz Jerzy Robak

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Identification and targeting molecular drug resistance mechanisms in adult B-cell acute lymphoblastic leukemia

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Identification of epigenetic mechanisms contributing to glioma drug resistance

Call: POLONEZ 3 , Panel: NZ2

Principal investigator: dr Jakub Karol Mieczkowski

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Role of mitophagy and assessement of bioenergetic status in podocytes in the development of insulin resistance and impai...

Call: SONATA 12 , Panel: NZ5

Principal investigator: dr Irena Audzeyenka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The role of cGMP-dependent signaling in the regulation of expression and activity of deacetylase SIRT1: a novel mechanis...

Call: OPUS 12 , Panel: NZ4

Principal investigator: dr Dorota Rogacka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Role of Prolactin-Induced Protein (PIP) in breast cancer progression using an adjuvant therapy.

Call: OPUS 12 , Panel: NZ5

Principal investigator: prof. Piotr Zbigniew Dzięgiel

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

The role of cancer stem cells in extracellular matrix production and drug resistance in ovarian cancer

Call: SONATA BIS 6 , Panel: NZ5

Principal investigator: dr hab. Radosław Januchowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Genetic features of Reed-Sternberg cells and their interplay with macrophages in classical Hodgkin lymphoma: identificat...

Call: HARMONIA 8 , Panel: NZ5

Principal investigator: prof. Krzysztof Zbigniew Warzocha

Instytut Hematologii i Transfuzjologii