Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Evaluation of anticancer properties and molecular mechanisms of action of new hybrid molecules containing uracil skeleton with an exo-cyclic methylene group

2017/25/N/NZ3/01039

Keywords:

apoptosis proliferation anticancer drug multidrug resistance activity of NF-kB ABC transporters

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Angelika Długosz-Pokorska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 13 - announced on 2017-03-15

Amount awarded: 149 700 PLN

Project start date (Y-m-d): 2018-03-22

Project end date (Y-m-d): 2024-09-21

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. New Uracil Analog with Exocyclic Methylidene Group Can Reverse Resistance to Taxol in MCF-7 Cancer Cells.
    Authors:
    Angelika Długosz-Pokorska , Renata Perlikowska , Tomasz Janecki , Anna Janecka
    Academic press:
    Biologics: Targets and Therapy (rok: 2023, tom: 17, strony: 69–83), Wydawca: Dovepress
    Status:
    Published
    DOI:
    10.2147/BTT.S405080 - link to the publication
  2. New uracil analogs as downregulators of ABC transporters in 5-fluorouracil-resistant human leukemia HL-60 cell line.
    Authors:
    Długosz-Pokorska Angelika, Pięta Marlena, Janecki Tomasz, Janecka Anna
    Academic press:
    Molecular Biology Reports (rok: 2019, tom: 46(6), strony: 5831-5839), Wydawca: Springer Science+Business Media
    Status:
    Published
    DOI:
    10.1007/s11033-019-05017-w - link to the publication
  3. New uracil analog U-332 is an inhibitor of NF-κB in 5-fluorouracil-resistant human leukemia HL-60 cell line
    Authors:
    Angelika Długosz-Pokorska, Marlena Pięta, Jacek Kędzia, Tomasz Janecki, Anna Janecka
    Academic press:
    BMC Pharmacology and Toxicology (rok: 2020, tom: 21, strony: 45301), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s40360-020-0397-4 - link to the publication
  4. New uracil analog with exocyclic methylidene group as potential anticancer agent.
    Authors:
    Angelika Długosz-Pokorska, Joanna Drogosz, Marlena Pięta, Tomasz Janecki, Urszula Krajewska, Marek Mirowski, Anna Janecka
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2020, tom: 20, strony: 359-368), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1871520619666191211104128 - link to the publication
  1. New Uracil Analog- U-359 can reverse resistance to Taxol in MCF-7 cancer cells
    Authors:
    Angelika Długosz-Pokorska, Renata Perlikowska, Tomasz Janecki, Anna Janecka
    Conference:
    the 5th BIO Congress (rok: 2023, ), Wydawca: Acta Biochmica Polonica
    Data:
    konferencja 13-16.09.2023
    Status:
    Published

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