Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Investigation of mechanisms of leptin-resistance induced by pregnancy in sheep

2013/09/B/NZ4/01532

Keywords:

leptin leptinresistance SOCS-3 sheep pregnancy lactation

Descriptors:

  • NZ4_8: Neuroendocrinology
  • NZ4_11: Metabolism
  • NZ4_2: Physiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Hodowli i Biologii Zwierząt

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Szczęsna 

Number of co-investigators in the project: 8

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 633 717 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2017-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (13)
  1. Phenomenon of leptin resistance in seasonal animals: the failure of leptin action in the brain
    Authors:
    Małgorzata Szczesna, Dorota Zięba
    Academic press:
    Domestic Animal Endocrinology (rok: 2015, tom: 52, strony: 60-70), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.domaniend.2015.03.002 - link to the publication
  2. The effects of leptin on plasma concentrations of prolactin, growth hormone, and melatonin vary depending on the stage of pregnancy in sheep
    Authors:
    Szczesna M., Kirsz K., Misztal T., Moilk E., Zieba D.A.
    Academic press:
    Journal of Animal Science (rok: 2018, tom: 96, strony: 3348-3357), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/jas/sky203 - link to the publication
  3. Seasonal fluctuations in the steady-state mRNA levels of suppressor of cytokine signaling-3 (SOCS-3) in the mammary gland of lactating and non-lactating ewes
    Authors:
    M. Szczesna, K. Kirsz, M. Kmiotek, D.A. Zieba
    Academic press:
    Small Ruminant Research (rok: 2015, tom: 124, strony: 101-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.smallrumres.2015.01.012 - link to the publication
  1. Effects of exogenous leptin on melatonin secretion during pregnancy in ewes
    Authors:
    Kirsz K., Szczesna M., Molik E., Misztal T., Zieba D.
    Conference:
    49th Annual Meeting of SSR "Systems of Biology Reproduction" (rok: 2016, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 16-20.07.2016
    Status:
    Published
  2. Effects of interaction between leptin and prolactin on SOCS-3 mRNA expression in ovine pituitary
    Authors:
    Szczęsna M., Kirsz K., Struzik N., Zięba D.A.
    Conference:
    9th International Congress of Comparative Physiology and Biochemistry "From Mollecules to Macrophysiology" (rok: 2015, ), Wydawca: Komitet Naukowy Konferencji
    Data:
    konferencja 23-28.08.2015
    Status:
    Published
  3. Effects of exogenous leptin on prolactin secretion in pregnant ewes
    Authors:
    Szczesna M., Kirsz K., Molik E., Zięba D.A.
    Conference:
    Central and local regulations of reproductive processes (rok: 2016, ), Wydawca: Komitet Naukowy Konferencji
    Data:
    konferencja 3-5.02.2016
    Status:
    Published
  4. Lactation-induced and photoperiod-driven changes od SOCS-3 gene expression in ovine mammary gland
    Authors:
    M. Szczesna, K. Kirsz, D.A. Zieba
    Conference:
    SSR 47th Annual Meeting " Fertility: A Global Challenge" (rok: 2014, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 19-23.07.2014
    Status:
    Published
  5. Leptin action and leptin-resistance during pregnancy in sheep
    Authors:
    Szczęsna M., Kirsz K., Zięba-Przybylska D.
    Conference:
    Biotechnology and welfare in animal sciences (rok: 2018, ), Wydawca: Komietet Naukowy Konferencji
    Data:
    konferencja 19.06.2018
    Status:
    Published
  6. Seasonal plasticity of the brain: the use of sheep model to study leptin resistance and obesity
    Authors:
    Zieba D., Szczęsna M., Kirsz K.
    Conference:
    13th International Congress of the Polish Neuroscience Society (rok: 2017, ), Wydawca: Polskie Towarzystwo Badań nad Układem Nerwowym
    Data:
    konferencja 28-31.08.2017
    Status:
    Published
  7. Effects of Leptin and Leptin Antagonist on Expression of SOCS-3 mRNA in the Ovine Pituitary
    Authors:
    Szczesna M., Kirsz K., Szafraniec A., Zieba D.A.
    Conference:
    SSR 48th Annual Meeting: Evolution of Sex" (rok: 2015, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 18-22.06.2015
    Status:
    Published
  8. Expression profile of suppressor of cytokine signaling-3 (SOCS-3) transcripts at selected stages of fetal development in lambs
    Authors:
    Szczesna M., Kirsz K., Wawrzyn A., Zieba D.
    Conference:
    VIII Zjazd Towarzystwa Biologii Rozrodu (rok: 2017, ), Wydawca: Komitet Naukowy Konferencji
    Data:
    konferencja 7-9.09.2017
    Status:
    Published
  9. Gestational profile of suppressor of cytokine signaling-3 (SOCS-3) transcripts in ovine brain and anterior pituitary
    Authors:
    Szczęsna M., Kirsz K., Zięba D.
    Conference:
    13th International Congress of the Polish Neuroscience Society (rok: 2017, ), Wydawca: Polskie Towaszystwo Badań nad Układem Nerwowym (PTBUN)
    Data:
    konferencja 28-31.08.2017
    Status:
    Published
  10. Wpływ laktacji oraz fotoperiodu na poziom transkrypcji genu SOCS-3 w gruczole mlekowym owiec
    Authors:
    M. Szczesna, K. Kirsz, M. Kmiotek, D. Zieba-Przybylska
    Conference:
    Molecular Research in Animal Science (rok: 2014, ), Wydawca: Komitet Naukowy Konferencji
    Data:
    konferencja 9-10.06.2014
    Status:
    Published
  11. Pregnancy-induced Changes in level of Suppressor of Cytokine Signaling-3 (SOCS-3) Transcripts in Ovine Brain and Adenohypophysis
    Authors:
    Zieba D., Szczesna M., Kirsz K.
    Conference:
    50th Annual Meeting of SSR "50 Years of Research: Looking Back and Moving Forward" (rok: 2017, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 13-16.07.2017
    Status:
    Published
  12. Pregnancy-induced changes in action of exogenous leptin on prolactin and growth hormone secretion in ewes
    Authors:
    Szczesna M., Kirsz K., Molik E., Sowinska N., Zieba D.
    Conference:
    49th Annual Meeting of SSR " Systems Biology of Reproduction" (rok: 2016, ), Wydawca: Society for the Study of Reproduction
    Data:
    konferencja 16-20.07.2016
    Status:
    Published
  13. Pregnancy-induced changes of leptin concentration in Polish Longwool ewes
    Authors:
    Szczesna M., Kirsz K., Zieba D.
    Conference:
    International Conference on Biotechnology and Welfare in Animal Science (rok: 2016, ), Wydawca: Komitet Naukowy Konferencji
    Data:
    konferencja 23-24.06.2016
    Status:
    Published

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