Characterization of aberrant mechanisms of telomere maintenance in chronic myeloid leukemia - the role of POT1 and RAP1 in genomic instability in leukemic stem cells
2015/19/B/NZ5/03501
Keywords
Descriptors
- NZ5_3: Patogeneza chorób człowieka
- NZ3_1: Biologia komórki
- NZ2_5: Cytogenetyka
Panel
NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution
Warszawski Uniwersytet Medyczny, Wydział Lekarski
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 10 – announced on 2015-09-15
- Amount awarded
- 1 004 800 PLN
- Project start date
- 2016-06-13
- Project end date
- 2021-06-12
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Equipment purchased [PL]
- Podręczny aparat do pomiaru stężenia kwasów nukleinowych i białek metodą fluorymetryczną (typu Qubit). Cost: 8 000 PLN
- System do preparatyki chromatyny do analizy duplikacji i delecji w regionach telomerowych. Cost: 90 000 PLN
- Termocykler PCR do analizy w czasie rzeczywistym o średniej przepustowości (z blokiem na płytki 96 oraz 384) wraz ze stacją komputerową oraz niezbędnym oprogramowaniem. Cost: 212 000 PLN
Information in the final report
Publication in academic press/journals (3)
-
Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells
- Authors:
- Anna Deręgowska, Anna Lewińska, Aleksandra Warzybok, Tomasz Stokłosa, Maciej Wnuk
- Academic press:
- Toxicology in Vitro (year: 2023, volume: 90, pages: 105608-105621), Publisher: PERGAMON-ELSEVIER SCIENCE LTD
- Status:
- Published
- DOI:
- 10.1016/j.tiv.2023.105608 – link to the publication
-
Differential regulation of telomeric complex by BCR-ABL1 kinase in cellular models of chronic myeloid leukemia - from single cell analysis to next-generation sequencing
- Authors:
- Anna Deręgowska, Monika Pępek, Katarzyna Pruszczyk, Marcin M Machnicki, Maciej Wnuk, Tomasz Stokłosa
- Academic press:
- Genes (year: 2020, volume: 11, pages: 46040), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/genes11101145 – link to the publication
-
The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia
- Authors:
- Anna Deręgowska, Monika Pępek, Iwona Solarska, Marcin M Machnicki, Katarzyna Pruszczyk, Marek Dudziński, Joanna Niesiobędzka-Krężel, Ilona Seferyńska, Waldemar Sawicki, Maciej Wnuk, Tomasz Stokłosa
- Academic press:
- Journal of Cancer Research and Clinical Oncology (year: 2023, volume: E-pub ahead of print, pages: E-pub ahead of print), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00432-023-04662-w – link to the publication