Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Characterization of aberrant mechanisms of telomere maintenance in chronic myeloid leukemia - the role of POT1 and RAP1 in genomic instability in leukemic stem cells

2015/19/B/NZ5/03501

Keywords:

chronic myeloid leukemia leukemia stem cells telomeres telomeric complex shelterin coplex genomic instability drug resistance

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ3_1: Cell biology
  • NZ2_5: Cell genetics

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Tomasz Stokłosa 

Number of co-investigators in the project: 6

Call: OPUS 10 - announced on 2015-09-15

Amount awarded: 1 004 800 PLN

Project start date (Y-m-d): 2016-06-13

Project end date (Y-m-d): 2021-06-12

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Podręczny aparat do pomiaru stężenia kwasów nukleinowych i białek metodą fluorymetryczną (typu Qubit) (8 000 PLN)
  2. Termocykler PCR do analizy w czasie rzeczywistym o średniej przepustowości (z blokiem na płytki 96 oraz 384) wraz ze stacją komputerową oraz niezbędnym oprogramowaniem (212 000 PLN)
  3. System do preparatyki chromatyny do analizy duplikacji i delecji w regionach telomerowych (90 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Telomere loss is accompanied by decreased pool of shelterin proteins TRF2 and RAP1, elevated levels of TERRA and enhanced glycolysis in imatinib-resistant CML cells
    Authors:
    Anna Deręgowska, Anna Lewińska, Aleksandra Warzybok, Tomasz Stokłosa, Maciej Wnuk
    Academic press:
    Toxicology in Vitro (rok: 2023, tom: 90, strony: 105608-105621), Wydawca: PERGAMON-ELSEVIER SCIENCE LTD
    Status:
    Published
    DOI:
    10.1016/j.tiv.2023.105608 - link to the publication
  2. The interplay between telomeric complex members and BCR::ABL1 oncogenic tyrosine kinase in the maintenance of telomere length in chronic myeloid leukemia
    Authors:
    Anna Deręgowska, Monika Pępek, Iwona Solarska, Marcin M Machnicki, Katarzyna Pruszczyk, Marek Dudziński, Joanna Niesiobędzka-Krężel, Ilona Seferyńska, Waldemar Sawicki, Maciej Wnuk, Tomasz Stokłosa
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2023, tom: E-pub ahead of print, strony: E-pub ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-023-04662-w - link to the publication
  3. Differential regulation of telomeric complex by BCR-ABL1 kinase in cellular models of chronic myeloid leukemia - from single cell analysis to next-generation sequencing
    Authors:
    Anna Deręgowska, Monika Pępek, Katarzyna Pruszczyk, Marcin M Machnicki, Maciej Wnuk, Tomasz Stokłosa
    Academic press:
    Genes (rok: 2020, tom: 11, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/genes11101145 - link to the publication

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