Projects funded by the NCN

Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

Call: OPUS 28 , Panel: NZ6

Principal investigator: dr Renata Grzywa

Politechnika Wrocławska

Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Aleksandra Dorota Helbik-Maciejewska

Uniwersytet Gdański

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Maria Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Marcin Wróbel

Uniwersytet Medyczny w Lublinie

Dietary polyphenols as thyroid peroxidase (TPO) modulators with multidirectional biological activity - a combined in vit...

Call: OPUS 17 , Panel: NZ9

Principal investigator: prof. Urszula Katarzyna Gawlik

Uniwersytet Przyrodniczy w Lublinie, Wydział Nauk o Żywności i Biotechnologii

Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

Call: SONATA BIS 8 , Panel: NZ1

Principal investigator: dr hab. Krzysztof Brzeziński

Instytut Chemii Bioorganicznej PAN

Molecular origins of mechanisms governing biological functions of enzymes with buried actives sites: substrate inhibitio...

Call: SONATA BIS 7 , Panel: NZ1

Principal investigator: dr Jan Brezovsky

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Marcin Jarosław Ziemniak

Uniwersytet Warszawski, Wydział Chemii

The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascu...

Call: PRELUDIUM 11 , Panel: NZ7

Principal investigator: Marek Toczek

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Stanisław Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Impact of the engineered mono-dispersed Fe3O4@SiO2 nanoparticles on a fungal enzyme inhibition in vitro

Call: PRELUDIUM 9 , Panel: NZ7

Principal investigator: Ahmet Kertmen

Politechnika Gdańska, Wydział Chemiczny

The impact of P450 and UGT isoenzyme overexpression on cellular response induced by antitumor acridinone derivatives. Th...

Call: OPUS 5 , Panel: NZ3

Principal investigator: prof. Zofia Mazerska

Politechnika Gdańska, Wydział Chemiczny

Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

Call: MAESTRO 4 , Panel: NZ1

Principal investigator: prof. Edward Darżynkiewicz

Uniwersytet Warszawski

Metabolic stability and inhibition of P450 enzymes in combination with chemometric techniques as a tool for selection of...

Call: OPUS 2 , Panel: NZ1

Principal investigator: prof. Tomasz Bączek

Gdański Uniwersytet Medyczny, Wydział Farmcautyczny z Oddziałem Medycyny Laboratoryjnej

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Alicja Tudek

Instytut Biochemii i Biofizyki PAN