Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascular system, oxidative stress and inflammation in spontaneously hypertensive and normotensive rats.

2016/21/N/NZ7/02338

Keywords:

JZL195 endocannabinoids hypertension oxidative stress inflammation FAAH MAGL

Descriptors:

  • NZ7_12: Prevention of human diseases
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

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Other projects carried out by the institution 

Principal investigator (from the host institution):

Marek Toczek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 11 - announced on 2016-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2017-03-14

Project end date (Y-m-d): 2022-03-13

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Enhanced endocannabinoid tone as a potential target of pharmacotherapy
    Authors:
    Marek Toczek, Barbara Malinowska
    Academic press:
    Life Sciences (rok: 2018, tom: 204, strony: 20-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2018.04.054. - link to the publication
  2. Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
    Authors:
    Marek Toczek, Piotr Ryszkiewicz, Patryk Remiszewski, Eberhard Schlicker, Anna Krzyżewska, Hanna Kozłowska, Barbara Malinowska
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(13), strony: 10942), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/ijms241310942 - link to the publication

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