The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascular system, oxidative stress and inflammation in spontaneously hypertensive and normotensive rats.
2016/21/N/NZ7/02338
Keywords
Descriptors
- NZ7_12: Prewencja chorób człowieka
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
Voivodeship: podlaskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 11 – announced on 2016-03-15
- Amount awarded
- 150 000 PLN
- Project start date
- 2017-03-14
- Project end date
- 2022-03-13
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (2)
-
Enhanced endocannabinoid tone as a potential target of pharmacotherapy
- Authors:
- Marek Toczek, Barbara Malinowska
- Academic press:
- Life Sciences (year: 2018, volume: 204, pages: 20-45), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.lfs.2018.04.054. – link to the publication
-
Weak Hypotensive Effect of Chronic Administration of the Dual FAAH/MAGL Inhibitor JZL195 in Spontaneously Hypertensive Rats as Revealed by Area under the Curve Analysis
- Authors:
- Marek Toczek, Piotr Ryszkiewicz, Patryk Remiszewski, Eberhard Schlicker, Anna Krzyżewska, Hanna Kozłowska, Barbara Malinowska
- Academic press:
- International Journal of Molecular Sciences (year: 2023, volume: 24(13), pages: 10942), Publisher: MDPI (Multidisciplinary Digital Publishing Institute)
- Status:
- Published
- DOI:
- 10.3390/ijms241310942 – link to the publication