Projects funded by the NCN

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348 projects found matching your search criteria :

  1. Targeting MMP-9 in Cancer Treatment: Computational Design and Experimental Validation of Potent, Safe Antitumor Agents

    Call: SONATA BIS 15 , Panel: ST5

    Principal investigator: dr Anna Żądło-Dobrowolska

    Instytut Chemii Organicznej Polska Akademia Nauk

  2. The JAK/STAT pathway as a molecular contributor to the development of endometriosis: therapeutic potential of JAK inhibi...

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Aleksander Radosław Rycerz

    Uniwersytet Medyczny w Łodzi

  3. The Impact of Endocannabinoid System Modulation and Enriched Environment on the Therapy of Myelination and Memory Disord...

    Call: PRELUDIUM 24 , Panel: NZ5

    Principal investigator: Justyna Anna Socha

    Uniwersytet Medyczny w Lublinie

  4. Dual cell cycle blockade and immune checkpoint inhibition as a potential strategy of sequential anticancer therapy

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Alicja Stanisława Słota

    Uniwersytet Jagielloński

  5. Novel covalent modulators of plasma kallikrein activity

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Jan Konopka

    Uniwersytet Jagielloński

  6. Disrupting the Toxic NMDAR/TRPM4 Protein Dialogue as a Novel Neuroprotective Strategy: Development of Small-Molecule Inh...

    Call: PRELUDIUM 24 , Panel: NZ7

    Principal investigator: Katarzyna Aleksandra Szafrańska

    Uniwersytet Jagielloński

  7. Development and study of peptide inhibitors of membrane fusion in flaviviruses, based on the STEM region of the tick-bor...

    Call: PRELUDIUM 24 , Panel: NZ6

    Principal investigator: Krzysztof Polaczek

    Uniwersytet Gdański

  8. The role of IFN-γ in inducing phenotype alterations and disulfidptosis in drug-naïve and BRAFV600/MEK inhibitor-resistan...

    Call: PRELUDIUM 24 , Panel: NZ4

    Principal investigator: Piotr Wawrzyniak

    Uniwersytet Medyczny w Łodzi

  9. Identification of molecular mechanisms of microglia repopulation in young and aged brains

    Call: PRELUDIUM 24 , Panel: NZ5

    Principal investigator: Zuzanna Małgorzata Łuczak-Sobotkowska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  10. New aryl difluoromethylenephosphonic acid and thiazole conjugates as effective PTP1B inhibitors used in the treatment of...

    Call: PRELUDIUM 24 , Panel: ST5

    Principal investigator: Dominika Agnieszka Kołodziej-Sobczak

    Uniwersytet Mikołaja Kopernika

  11. Inhibitors of the non-mevalonate isoprenoid biosynthesis pathway - a new class of antibiotics against tuberculosis and m...

    Call: SONATA 20 , Panel: ST5

    Principal investigator: dr Ignacy Przemysław Janicki

    Centrum Badań Molekularnych i Makromolekularnych PAN

  12. Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

    Call: SONATA 20 , Panel: ST5

    Principal investigator: dr Radosław Dariusz Kitel

    Uniwersytet Jagielloński

  13. A new feature of the yeast Kazachstania humilis species: Growth-inhibitory properties against a broad spectrum of bacter...

    Call: OPUS 28 , Panel: NZ9

    Principal investigator: dr hab. Anna Sikora

    Instytut Biochemii i Biofizyki PAN

  14. The role of JAK/STAT3 pathway and mast cells in endometriosis-related chronic pain

    Call: SONATA 20 , Panel: NZ5

    Principal investigator: dr Monika Anna Golińska

    Uniwersytet Medyczny w Łodzi

  15. Environmental modulation of CDK4/6 inhibitor efficacy: Impact of mycotoxin alternariol exposure on anti-cancer therapies

    Call: SONATA 20 , Panel: NZ5

    Principal investigator: dr Anna Dominika Walczak-Szeffer

    Uniwersytet Medyczny w Łodzi

  16. Human exosomes as natural carriers of protein kinase CK2 inhibitors and degraders in targeted anticancer therapy.

    Call: OPUS 28 (LAP) , Panel: NZ5

    Principal investigator: dr hab. Patrycja Joanna Wińska

    Politechnika Warszawska

  17. Tick-borne encephalitis virus protease as a molecular target for novel inhibitors and activity-based probes

    Call: OPUS 28 , Panel: NZ6

    Principal investigator: dr Renata Grzywa

    Politechnika Wrocławska

  18. Phytochemicals as inhibitors of polylactide's photooxidation and thermooxidation

    Call: SONATA 20 , Panel: ST11

    Principal investigator: dr Aleksander Mateusz Hejna

    Politechnika Poznańska

  19. Quad-TNT: Quadruplex-Targeted Photo-Therapy for Triple-Negative Tumors

    Call: SONATA BIS 14 , Panel: NZ5

    Principal investigator: dr Marco Deiana

    Politechnika Wrocławska

  20. Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: prof. Marta Katarzyna Karaźniewicz-Łada

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  21. Frog skin derived cyclic peptide as a molecular scaffold to create a novel tool for combining visualization and inhibiti...

    Call: PRELUDIUM 23 , Panel: ST5

    Principal investigator: Aleksandra Dorota Helbik-Maciejewska

    Uniwersytet Gdański

  22. Development of novel screening method for identifying xanthine oxidase inhibitors – towards new drug candidates for gout...

    Call: PRELUDIUM 23 , Panel: ST4

    Principal investigator: dr Monika Katarzyna Rola

    Politechnika Łódzka

  23. Innovative Small Molecule Inhibitors Targeting LAG-3 and MHCII Complex for Tumour Immunotherapy

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr Jacek Plewka

    Uniwersytet Jagielloński

  24. Behavioral timescale plasticity in inhibitory synapses: mechanisms and implications

    Call: OPUS 27 , Panel: NZ4

    Principal investigator: dr Grzegorz Tadeusz Wiera

    Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej

  25. Controlling the covalent activity of a PD-L1 inhibitors with light

    Call: PRELUDIUM 23 , Panel: NZ7

    Principal investigator: Wiktor Jan Uzar

    Uniwersytet Jagielloński

  26. Development and characterization of novel multitargeted organometallic tubulin polymerization inhibitors for enhancing t...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Damian Nestor Plażuk

    Uniwersytet Łódzki

  27. Towards a functional cure of HIV infection.

    Call: WEAVE-UNISONO , Panel: NZ6

    Principal investigator: dr Anna Kula-Pacurar

    Uniwersytet Jagielloński

  28. Early Intervention with mTOR Inhibitors for Neuropsychiatric Symptoms in Tuberous Sclerosis Complex: Unveiling Developme...

    Call: DAINA 3 , Panel: NZ4

    Principal investigator: prof. Ewelina Anna Knapska

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  29. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  30. Inhibitory Functional Networks in Addiction Development within Social Context - a Missing Piece of Puzzle

    Call: OPUS 26 , Panel: NZ4

    Principal investigator: dr Marzena Stefaniuk

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  31. Flozins as potential inhibitors of aortic stenosis progression in patients with concomitant type 2 diabetes: impact on v...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr hab. Joanna Natorska

    Uniwersytet Jagielloński

  32. Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Agnieszka Graczyk-Jarzynka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  33. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  34. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Krzysztof Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  35. Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Witold Szaflarski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

  36. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  37. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych PAN

  38. Compounds modulating function of telomeric proteins TRF1 and TRF2

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: prof. Maciej Wojciech Bagiński

    Politechnika Gdańska, Wydział Chemiczny

  39. Development of dual immuno-oligo- biosensors for monitoring and controlling of the metastatic colorectal cancer and inve...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr hab. Magdalena Stobiecka

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  40. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  41. Understanding the contribution of immunoproteasome activation to the neuropathic pain development.

    Call: OPUS 25 , Panel: NZ7

    Principal investigator: dr Natalia Eleonora Małek-Chudzik

    Politechnika Wrocławska

  42. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Aleksandra Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  43. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Anna Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  44. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Alicja Potok

    Uniwersytet Wrocławski, Wydział Chemii

  45. Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: dr Alicja Małgorzata Braczko

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  46. Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Piotr Maciej Chyży

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  47. Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

    Call: PRELUDIUM 22 , Panel: NZ6

    Principal investigator: dr Dorota Suszczyk

    Uniwersytet Medyczny w Lublinie

  48. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Jun Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  49. New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr Edyta Dyguda-Kazimierowicz

    Politechnika Wrocławska

  50. Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Sylwia Anna Biały

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

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