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Information on the principal investigator and host institution

Information of the project and the call

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Cardioprotective effect of inhibitors of matrix metalloproteinase-2 (MMP-2) and inhibitors of posttanslational modifications of myosin light chain 1,2 (MLC1,2) on function of heart during ischemia/reperfusion-induced injury.

2012/06/M/NZ3/00158

Keywords:

MLC modification inhibitors MMP-2 I/R heart injury

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mieczysław Woźniak 

Number of co-investigators in the project: 4

Call: HARMONIA 3 - announced on 2012-06-15

Amount awarded: 516 100 PLN

Project start date (Y-m-d): 2013-04-22

Project end date (Y-m-d): 2016-04-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Subthreshold nitric oxide synthase inhibition improves synergistic effects of subthreshold MMP-2/MLCK-mediated cardiomyocyte protection from hypoxic injury
    Authors:
    Bil-Lula I, Lin HB, Biały D, Wawrzyńska M, Diebel L, Sawicka J, Woźniak M, Sawicki G.
    Academic press:
    J Cell Mol Med. (rok: 2016, tom: 20, strony: 1086-94), Wydawca: John Wiley & Sons Ltd and Foundation for Cellular and Molecular
    Status:
    Published
    DOI:
    10.1111/jcmm.12827 - link to the publication
  2. Inhibition of MMP-2 expression affects metabolic enzyme expression levels: proteomic analysis of rat cardiomyocytes.
    Authors:
    Lin HB, Sharma K, Bialy D, Wawrzynska M, Purves R, Cayabyab FS, Wozniak M, Sawicki G
    Academic press:
    J Proteomics (rok: 2014, tom: 106, strony: 74-85), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jprot.2014.04.026 - link to the publication
  3. Intracellular Regulation of Matrix Metalloproteinase-2 Activity: New Strategies in Treatment and Protection of Heart Subjected to Oxidative Stress
    Authors:
    Sawicki Grzegorz
    Academic press:
    Scientifica (Cairo). (rok: 2013, tom: 2013: 130451, strony: 45303), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2013/130451 - link to the publication

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