Projects funded by the NCN

DEVELOPMENT AND ANALYSIS OF SMALL COMPOUNDS AS CANDIDATE INHIBITORS OF PLANT GROUP A PROTEIN PHOSPHATASES TYPE 2C

Call: SONATA BIS 6 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Ludwików

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Thiol oxidoreductases of Helicobacter spp. - biochemical and structural characterization of the H. hepaticus Dsb system ...

Call: OPUS 15 , Panel: NZ1

Principal investigator: prof. Dariusz Bartosik

Uniwersytet Warszawski, Wydział Biologii

Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

Call: PRELUDIUM 2 , Panel: ST4

Principal investigator: Martyna Maszota-Zieleniak

Uniwersytet Gdański, Wydział Chemii

Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

Call: OPUS 2 , Panel: NZ9

Principal investigator: dr hab. Aleksandra Obrępalska-Stęplowska

Instytut Ochrony Roślin - Państwowy Instytut Badawczy

The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymo...

Call: OPUS 5 , Panel: NZ1

Principal investigator: dr Krzysztof Brzeziński

Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

Call: HARMONIA 5 , Panel: NZ4

Principal investigator: dr hab. Krzysztof Nieznański

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Study on the mechanism of cancer cell growth inhibition by synergistic activation of p53 protein caused by combined trea...

Call: OPUS 6 , Panel: NZ5

Principal investigator: dr hab. Marek Rusin

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

Modification of cellular aging in vitro by inhibitors of non-enzymatic protein modifications

Call: OPUS 9 , Panel: NZ3

Principal investigator: prof. Grzegorz Bartosz

Uniwersytet Rzeszowski, Kolegium Nauk Przyrodniczych

Structure and function characterization of newly discovered unique inhibitors of proteases

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Lipidic liquid-crystalline nanomaterials for reconstitution and physico-chemical studies of membrane proteins

Call: OPUS 22 , Panel: ST4

Principal investigator: prof. Renata Bilewicz

Uniwersytet Warszawski, Wydział Chemii

SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

Call: PRELUDIUM BIS 3 , Panel: ST4

Principal investigator: dr hab. Katarzyna Magdalena Błażewska

Politechnika Łódzka, Wydział Chemiczny

Identification and characterization of specific carp (Cyprinu carpio L) seminal plasma proteins – proteomics and classic...

Call: SONATA 1 , Panel: NZ9

Principal investigator: dr Mariola Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności Polskiej Akademii Nauk

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

Call: SONATA BIS 9 , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Restoration of beta-cell function via inhibition of diabetic kinome.

Call: SONATA BIS 9 , Panel: NZ1

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński

Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

Call: PRELUDIUM BIS 3 , Panel: NZ5

Principal investigator: prof. Ireneusz Jacek Majsterek

Uniwersytet Medyczny w Łodzi

Protein and gene expression analysis in the course of renal cancer stem-like cells' primary resistance to sorafenib in h...

Call: PRELUDIUM 9 , Panel: NZ5

Principal investigator: Zofia Bielecka

Wojskowy Instytut Medyczny

Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Marta Sosnowska

Uniwersytet Gdański, Wydział Chemii

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Zika virus NS3 protease

Call: OPUS 11 , Panel: NZ6

Principal investigator: dr hab. Krzysztof Pyrć

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Role of FMRP protein in the regulation of BRCA1 translation in leukemia cells.

Call: PRELUDIUM 12 , Panel: NZ3

Principal investigator: Magdalena Wołczyk

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

Call: OPUS 15 , Panel: NZ6

Principal investigator: dr hab. Marcin Sieńczyk

Politechnika Wrocławska

Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors ...

Call: SONATA 14 , Panel: NZ1

Principal investigator: dr hab. Miłosz Ruszkowski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

Call: SONATA BIS 4 , Panel: ST5

Principal investigator: dr hab. Katarzyna Błażewska

Politechnika Łódzka, Wydział Chemiczny

Multifunctional inhibitors of beta-secretase with anti-aggregating properties of neurotoxic peptides - beta-amyloid and ...

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Barbara Malawska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

Call: PRELUDIUM BIS 2 , Panel: ST4

Principal investigator: dr hab. Adam Kazimierz Sieradzan

Uniwersytet Gdański, Wydział Chemii

Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Kamil Przyborowski

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr Karolina Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Emilia Sługocka

Uniwersytet Jagielloński, Collegium Medicum

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Inhibitors, protein aggregation and carbon nanotube

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Mai Li

INSTYTUT FIZYKI PAN

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Walczak

Politechnika Wrocławska, Wydział Chemiczny

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

Call: OPUS 7 , Panel: NZ5

Principal investigator: dr hab. Marzena Wojciechowska

Instytut Chemii Bioorganicznej PAN

Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpe...

Call: ETIUDA 8 , Panel: NZ3

Principal investigator: Magda Dominika Wąchalska

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

Call: OPUS 19 , Panel: NZ1

Principal investigator: prof. Mariusz Jaskólski

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

Call: OPUS 19 , Panel: ST4

Principal investigator: prof. Wiktor Adam Koźmiński

Uniwersytet Warszawski, Wydział Chemii

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhib...

Call: PRELUDIUM 4 , Panel: NZ2

Principal investigator: Małgorzata Szeląg

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Oxopiperazine peptidomimetics as potential PEX14-PE5 protein-protein interaction inhibitors

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Maciej Dawidowski

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

Novel inhibitors of herpes virus protease

Call: PRELUDIUM 14 , Panel: NZ6

Principal investigator: Magdalena Pachota

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Investigation of the antitumor potential of stimulator of interferon genes (STING) - an adaptor protein in innate immune...

Call: PRELUDIUM 9 , Panel: NZ6

Principal investigator: Olga Sokołowska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Application of approximate non-empirical model based on long-range terms of interaction energy for assessment of inhibit...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Wiktoria Jedwabny (z d. Giedroyć-Piasecka)

Politechnika Wrocławska, Wydział Chemiczny

Transient protein states in designing small-molecule inhibitors of protein-protein interactions

Call: SYMFONIA 2 , Panel: NZ1

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Inhibitors of serine proteases as regulators of dendritic cell function.

Call: MAESTRO 1 , Panel: NZ5

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii