Projects funded by the NCN


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58 projects found matching your search criteria :

  1. Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Adam Lesner

    Uniwersytet Gdański, Wydział Chemii

  2. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

    Call: SONATA BIS 4 , Panel: ST5

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  3. Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

    Call: OPUS 7 , Panel: NZ5

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej PAN

  4. Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Agata Gitlin-Domagalska

    Uniwersytet Gdański, Wydział Chemii

  5. Transient protein states in designing small-molecule inhibitors of protein-protein interactions

    Call: SYMFONIA 2 , Panel: NZ1

    Principal investigator: prof. Tadeusz Holak

    Uniwersytet Jagielloński, Wydział Chemii

  6. Study on the mechanism of cancer cell growth inhibition by synergistic activation of p53 protein caused by combined trea...

    Call: OPUS 6 , Panel: NZ5

    Principal investigator: dr hab. Marek Rusin

    Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

  7. Conjugates of prion protein with dendrimers as inhibitors of Abeta peptide amyloidogenesis and cytotoxicity of potential...

    Call: HARMONIA 5 , Panel: NZ4

    Principal investigator: dr hab. Krzysztof Nieznański

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  8. Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

    Call: SONATA BIS 3 , Panel: NZ5

    Principal investigator: prof. Dominika Nowis

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  9. The active center and beyond: towards new selective inhibitors of S-adenosyl-L-homocysteine hydrolase. Structural enzymo...

    Call: OPUS 5 , Panel: NZ1

    Principal investigator: dr Krzysztof Brzeziński

    Uniwersytet w Białymstoku, Wydział Biologiczno-Chemiczny

  10. Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Maciej Walczak

    Politechnika Wrocławska, Wydział Chemiczny

  11. Design and synthesis of selective and irreversible inhibitors of HAT protease.

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Marcin Skoreński

    Politechnika Wrocławska, Wydział Chemiczny

  12. Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

    Call: PRELUDIUM 1 , Panel: NZ1

    Principal investigator: Michał Zdżalik

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  13. Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

    Call: SYMFONIA 1 , Panel: NZ1

    Principal investigator: prof. Jan Potempa

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  14. Designing mRNA transcripts resistant to enzymatic cap hydrolysis applicable for anti-cancer vaccines; multiplexed bioche...

    Call: MAESTRO 4 , Panel: NZ1

    Principal investigator: prof. Edward Darżynkiewicz

    Uniwersytet Warszawski, Centrum Nowych Technologii

  15. Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhib...

    Call: PRELUDIUM 4 , Panel: NZ2

    Principal investigator: Małgorzata Szeląg

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  16. Protein tyrosine phosphatases inhibition as a strategy against infectious diseases and bioterrorism

    Call: PRELUDIUM 4 , Panel: NZ1

    Principal investigator: dr Alicja Kuban-Jankowska

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  17. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

  18. Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

    Call: OPUS 2 , Panel: NZ9

    Principal investigator: dr hab. Aleksandra Obrępalska-Stęplowska

    Instytut Ochrony Roślin - Państwowy Instytut Badawczy

  19. Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

    Call: PRELUDIUM 2 , Panel: ST4

    Principal investigator: Martyna Maszota-Zieleniak

    Uniwersytet Gdański, Wydział Chemii

  20. Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

    Call: PRELUDIUM 2 , Panel: NZ5

    Principal investigator: Marta Sosnowska

    Uniwersytet Gdański, Wydział Chemii

  21. Functional and structural analysis of anticancer drugs as protein biosynthesis inhibitors

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr hab. Witold Szaflarski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

  22. Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

    Call: OPUS 25 , Panel: ST4

    Principal investigator: prof. Arkadiusz Chworoś

    Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

  23. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  24. New applications of non-conventional nonempirical methodologies for the analysis of catalytic and inhibitory properties ...

    Call: OPUS 25 , Panel: ST4

    Principal investigator: dr Edyta Dyguda-Kazimierowicz

    Politechnika Wrocławska

  25. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  26. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  27. SELECTIVE REGULATION OF RAB GTPASES BY TARGETING PROTEIN-PROTEIN INTERACTIONS BETWEEN RABS AND REGULATORY PROTEINS

    Call: PRELUDIUM BIS 3 , Panel: ST4

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  28. Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Kamil Przyborowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  29. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Majsterek

    Uniwersytet Medyczny w Łodzi

  30. Lipidic liquid-crystalline nanomaterials for reconstitution and physico-chemical studies of membrane proteins

    Call: OPUS 22 , Panel: ST4

    Principal investigator: prof. Renata Bilewicz

    Uniwersytet Warszawski, Wydział Chemii

  31. Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

    Call: PRELUDIUM BIS 2 , Panel: ST4

    Principal investigator: dr hab. Adam Sieradzan

    Uniwersytet Gdański, Wydział Chemii

  32. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  33. Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

    Call: OPUS 19 , Panel: ST4

    Principal investigator: prof. Wiktor Koźmiński

    Uniwersytet Warszawski, Wydział Chemii

  34. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  35. Participation of cellular proteins in the inhibition of antigen presentation dependent on UL49.5 protein of bovine herpe...

    Call: ETIUDA 8 , Panel: NZ3

    Principal investigator: Magda Wąchalska

    Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

  36. Inhibitors of serine proteases as regulators of dendritic cell function.

    Call: MAESTRO 1 , Panel: NZ5

    Principal investigator: prof. Joanna Cichy

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  37. Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

    Call: SONATA 15 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  38. Restoration of beta-cell function via inhibition of diabetic kinome.

    Call: SONATA BIS 9 , Panel: NZ1

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński

  39. Multitarget approach to break the vicious circle of tau pathology and neuroinflammation in Alzheimer's disease: developm...

    Call: SONATA BIS 9 , Panel: NZ7

    Principal investigator: dr hab. Anna Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  40. Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: dr hab. Maciej Dawidowski

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  41. Histidine Biosynthetic Pathway in Plants: Structural and Functional Studies as a Framework for the Design of Inhibitors ...

    Call: SONATA 14 , Panel: NZ1

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  42. CP protease of the O'nyong-nyong virus: substrate profiling, design and synthesis of inhibitors and activity-based probe...

    Call: OPUS 15 , Panel: NZ6

    Principal investigator: dr hab. Marcin Sieńczyk

    Politechnika Wrocławska

  43. Thiol oxidoreductases of Helicobacter spp. - biochemical and structural characterization of the H. hepaticus Dsb system ...

    Call: OPUS 15 , Panel: NZ1

    Principal investigator: prof. Dariusz Bartosik

    Uniwersytet Warszawski, Wydział Biologii

  44. Novel inhibitors of herpes virus protease

    Call: PRELUDIUM 14 , Panel: NZ6

    Principal investigator: Magdalena Pachota

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  45. Oxopiperazine peptidomimetics as potential PEX14-PE5 protein-protein interaction inhibitors

    Call: OPUS 12 , Panel: NZ7

    Principal investigator: dr hab. Maciej Dawidowski

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  46. Role of FMRP protein in the regulation of BRCA1 translation in leukemia cells.

    Call: PRELUDIUM 12 , Panel: NZ3

    Principal investigator: Magdalena Wołczyk

    Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

  47. DEVELOPMENT AND ANALYSIS OF SMALL COMPOUNDS AS CANDIDATE INHIBITORS OF PLANT GROUP A PROTEIN PHOSPHATASES TYPE 2C

    Call: SONATA BIS 6 , Panel: NZ3

    Principal investigator: dr hab. Agnieszka Ludwików

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  48. Application of approximate non-empirical model based on long-range terms of interaction energy for assessment of inhibit...

    Call: PRELUDIUM 11 , Panel: ST4

    Principal investigator: Wiktoria Jedwabny (z d. Giedroyć-Piasecka)

    Politechnika Wrocławska, Wydział Chemiczny

  49. Zika virus NS3 protease

    Call: OPUS 11 , Panel: NZ6

    Principal investigator: dr hab. Krzysztof Pyrć

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  50. Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

    Call: PRELUDIUM 11 , Panel: ST4

    Principal investigator: Anna Wojtczak

    Uniwersytet Warszawski, Wydział Fizyki