Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the course of synucleinopathy

2021/43/O/NZ5/02068

Keywords:

neurodegeneration alpha-synuclein Parkinson's disease endoplasmic reticulum stress PERK kinase small-molecule inhibitors

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment
  • NZ3_5: Molecular neurobiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny w Łodzi

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ireneusz Jacek Majsterek 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 3 - announced on 2021-09-15

Amount awarded: 675 000 PLN

Project start date (Y-m-d): 2022-10-01

Project end date (Y-m-d): 2026-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (4)
  1. Alpha-Synuclein Contribution to Neuronal and Glial Damage in Parkinson's Disease
    Authors:
    Kamil Saramowicz, Natalia Siwecka, Grzegorz Galita, Aleksandra Kucharska-Lusina, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 25(1), strony: 360), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25010360 - link to the publication
  2. GBA1 Gene Mutations in α-Synucleinopathies—Molecular Mechanisms Underlying Pathology and Their Clinical Significance
    Authors:
    Zuzanna Granek, Julia Barczuk, Natalia Siwecka, Wioletta Rozpędek-Kamińska, Ewa Kucharska, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24(3), strony: 2044), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24032044 - link to the publication
  3. Inhibition of Protein Aggregation and Endoplasmic Reticulum Stress as a Targeted Therapy for α-Synucleinopathy
    Authors:
    Natalia Siwecka, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Ireneusz Majsterek
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 15(8), strony: 2051), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15082051 - link to the publication
  1. Inhibition of the Unfolded Protein Response signaling pathway as a novel target in Parkinson's disease: an in vitro study
    Authors:
    Natalia Siwecka, Zuzanna Granek
    Conference:
    Abstract Book 23rd International Congress of Young Medical Scientists (rok: 2023, tom: 23rd International Congress of Young Medical Scientists, strony: 94), Wydawca: PUMS Students' Scientific Association
    Data:
    konferencja 25-27.05.2023
    Status:
    Published
  2. Neuroprotective effect of UPR inhibitor in Parkinson's Disease cellular model
    Authors:
    Zuzanna Granek
    Conference:
    SIMC Abstracts' Book (rok: 2023, tom: International Medical Congress of Silesia, strony: 50), Wydawca: Students' Scientific Association of Medical University of Silesia
    Data:
    konferencja 17-19.05.2023
    Status:
    Published
  3. In vitro activity of new small-molecule PERK inhibitor in Parkinson's disease cellular model
    Authors:
    Natalia Siwecka, Zuzanna Granek, Kamil Saramowicz, Grzegorz Galita, Wioletta Rozpędek-Kamińska, Dariusz Pytel, J. Alan Diehl, Ireneusz Majsterek
    Conference:
    Acta Medica (Hradec Králové) (rok: 2023, tom: 20th International Medical Doctoral Conference, strony: 92-93), Wydawca: Karolinum Press
    Data:
    konferencja 29.11-01.12.2023
    Status:
    Published
    DOI:
    10.14712/18059694.2023.20 - link to the publication
  4. Small-molecule PERK inhibitor provides neuroprotection in Parkinson's disease cellular model
    Authors:
    Zuzanna Granek, Kamil Saramowicz
    Conference:
    Abstract Book 23rd International Congress of Young Medical Scientists (rok: 2023, tom: 23rd International Congress of Young Medical Scientists, strony: 61-62), Wydawca: PUMS Students' Scientific Association
    Data:
    konferencja 25-27.05.2023
    Status:
    Published

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