Projects funded by the NCN

From Static to Dynamic: Integrating Glycan Dynamics into Structural Biology

Call: SONATA BIS 14 , Panel: NZ1

Principal investigator: dr Mateusz Sikora

Uniwersytet Jagielloński

Insight into the function of post-translational modifications of proteins via large-size scale and long-scale molecular ...

Call: SONATA 19 , Panel: ST4

Principal investigator: dr Agnieszka Gabriela Lipska

Politechnika Gdańska

Correlated mean-field interactions propagated along polypeptide chain as a key to understanding the structure formation,...

Call: OPUS 26 , Panel: ST4

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Determination of the dynamics of changes in protein networks interacting with selected isoforms of the protein phosphata...

Call: OPUS 26 , Panel: NZ9

Principal investigator: dr hab. Danuta Anna Babula-Skowrońska

Instytut Genetyki Roślin PAN

Exposing unseen passages - towards identification of functional transient tunnels in protein structures

Call: PRELUDIUM BIS 5 , Panel: NZ2

Principal investigator: dr hab. Jan Brezovský

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Theoretical prediction, chemical synthesis and biological analysis of a novel class of HSPA5 inhibitors

Call: OPUS 25 , Panel: ST4

Principal investigator: prof. Arkadiusz Chworoś

Centrum Badań Molekularnych i Makromolekularnych PAN

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

Optimization of coarse-grained molecular dynamics simulations for tunnel exploration of large proteins with buried activ...

Call: PRELUDIUM 22 , Panel: NZ2

Principal investigator: Nishita Mandal

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Decrypting the "sulfation code" of glycosaminoglycans for understanding their function in the extracellular matrix

Call: OPUS 25 , Panel: ST4

Principal investigator: dr hab. Sergey Samsonov

Uniwersytet Gdański, Wydział Chemii

The thylakoid soluble phosphoprotein 9 (TSP9) as a novel partner of plant cytochrome b6f - exploring dynamics of its int...

Call: OPUS 24 , Panel: NZ1

Principal investigator: prof. Artur Osyczka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Co-translational protein folding in the light of ribosome evolution

Call: POLONEZ BIS 3 , Panel: NZ1

Principal investigator: dr Tomasz Włodarski

Instytut Biochemii i Biofizyki PAN

Function, organization, dynamics, and evolution of hyperbranched receptor-binding protein systems in Klebsiella jumbo ph...

Call: OPUS 24 (LAP) , Panel: NZ1

Principal investigator: prof. Zuzanna Drulis-Kawa

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

Call: SONATA BIS 12 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Dynamics and evolution of specificity of TA complexes

Call: POLONEZ BIS 2 , Panel: NZ1

Principal investigator: dr Grzegorz Jan Grabe

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Data-assisted modeling of the ensemble structure of intrinsically disordered proteins and their assemblies

Call: SHENG 2 , Panel: ST4

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Assessing protein-ligand complexes with ML/DL models trained on molecular dynamics-based descriptors.

Call: OPUS 20 , Panel: ST4

Principal investigator: dr hab. Paweł Aleksander Siedlecki

Instytut Biochemii i Biofizyki PAN

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

The influence of environment on biomolecular function, structure and interactions.

Call: SONATA BIS 10 , Panel: ST4

Principal investigator: dr hab. Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Quantifying evolutionary dynamics of tails in phages infecting bacteria of Klebsiella pneumoniae

Call: OPUS 19 , Panel: NZ8

Principal investigator: dr Rafał Mostowy

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Computational studies of the disulfide-bond role in proteins.

Call: SONATA 15 , Panel: ST4

Principal investigator: dr Paweł Krupa

Instytut Fizyki PAN

Seeking for CB1 and CB2 receptor ligands among drugs, drug metabolites, and phytochemical compounds

Call: PRELUDIUM 18 , Panel: NZ7

Principal investigator: Adam Stasiulewicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Computational study of protein folding and dimerization on the ribosome

Call: OPUS 18 , Panel: ST4

Principal investigator: prof. Mai Suan Li

Instytut Fizyki PAN

Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

Call: SONATA 15 , Panel: ST4

Principal investigator: dr hab. Karolina Anna Mikulska-Rumińska

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Novel methods for structural biology of large symmetric protein assemblies by solid-state Nuclear Magnetic Resonance (NM...

Call: OPUS 17 , Panel: ST4

Principal investigator: dr Jan Grzegorz Stanek

Uniwersytet Warszawski, Wydział Chemii

Computational insights into procathepsin maturation mediated by glycosaminoglycans.

Call: PRELUDIUM 16 , Panel: ST4

Principal investigator: Krzysztof Kamil Bojarski

Uniwersytet Gdański, Wydział Chemii

Modeling of glycosaminoglycan-induced formation of protein structure and enhancement of biologically relevant protein-li...

Call: SONATA BIS 8 , Panel: ST4

Principal investigator: dr Sergey Samsonov

Uniwersytet Gdański, Wydział Chemii

An integrated approach to modeling protein structure and dynamics based on the UNRES coarse-grained force field and bioi...

Call: HARMONIA 9 , Panel: ST4

Principal investigator: dr hab. Cezary Ryszard Czaplewski

Uniwersytet Gdański, Wydział Chemii

Increasing global and local accuracy of the coarse-grained UNRES model of proteins and its extensions to simulating very...

Call: OPUS 13 , Panel: ST4

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Enabling routine and reliable analysis of transport tunnels in proteins

Call: OPUS 13 , Panel: NZ1

Principal investigator: dr Jan Brezovsky

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Structural determinants of optical control of insulin and neuroligin release by photoactive protein ligands.

Call: OPUS 12 , Panel: ST4

Principal investigator: prof. Wiesław Nowak

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Mechanism of substrate recognition and binding by gamma-secretase on the example of the amyloid precursor protein

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Łukasz Piotr Nierzwicki

Politechnika Gdańska, Wydział Chemiczny

Structure and reactivity of proteins in the gas phase - a meeting between advanced mass spectrometry and molecular model...

Call: HARMONIA 8 , Panel: ST4

Principal investigator: dr Jarosław Jan Panek

Uniwersytet Wrocławski, Wydział Chemii

Multiple functions of RFC protein complex in the architecture and dynamics of replication factories in cell nuclei

Call: PRELUDIUM 11 , Panel: NZ3

Principal investigator: Maciej Włodzimierz Krupa

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Computational approaches to study protein-glycosaminoglycan interactions

Call: POLONEZ 2 , Panel: ST4

Principal investigator: dr Sergey Samsonov

Uniwersytet Gdański, Wydział Chemii

Dynamic changes of carp seminal proteins and their modifications upon sperm maturation, hormonal stimulation and storage...

Call: OPUS 11 , Panel: NZ9

Principal investigator: dr hab. Mariola Aleksandra Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Memetic algorithms for the excited ligand diffusion in condensed biological matter

Call: PRELUDIUM 10 , Panel: ST3

Principal investigator: Jakub Mateusz Rydzewski

Uniwersytet Mikołaja Kopernika, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Structure-based dynamical models of large and complex biomolecular systems

Call: OPUS 8 , Panel: ST3

Principal investigator: prof. Marek Cieplak

Instytut Fizyki PAN

Molecular basis of amyloidogenesis - structure of conformational dynamics slected complexes of human prion protein PrPc ...

Call: OPUS 8 , Panel: ST4

Principal investigator: prof. Maciej Leszek Kozak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

Structural and biophysical characteristics of highly conserved zinc hook domain of Rad50 protein - Studies on stability ...

Call: OPUS 7 , Panel: NZ1

Principal investigator: dr hab. Artur Krężel

Uniwersytet Wrocławski, Wydział Biotechnologii

Structural and dynamic aspect of the electrostatic interaction in HIV-1 protease.

Call: PRELUDIUM 7 , Panel: ST4

Principal investigator: Prashant Kumar

Uniwersytet Warszawski, Wydział Chemii

Modeling realistic tear film structure including tear protein and analyzing its role in stability and biophysical proper...

Call: PRELUDIUM 6 , Panel: ST7

Principal investigator: Alicja Ewa Wizert

Politechnika Wrocławska, Wydział Podstawowych Problemów Techniki

Hydration effects in protein kinases

Call: SONATA 6 , Panel: ST4

Principal investigator: dr Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Protein stability in aqueous solutions of osmolytes studied through complementary theoretical and experimental approach

Call: OPUS 6 , Panel: NZ1

Principal investigator: prof. Janusz Antoni Stangret

Politechnika Gdańska, Wydział Chemiczny

An integrated approach to the prediction of the structures of proteins and protein complexes with the use of the coarse-...

Call: HARMONIA 5 , Panel: ST4

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Design, parametrization and implementation of potentials of amino acid side chain interactions in water for application ...

Call: SONATA BIS 3 , Panel: ST4

Principal investigator: dr hab. Mariusz Makowski

Uniwersytet Gdański, Wydział Chemii

Simulation of conformational changes related to the interdomain communication in the eukaryotic GlcN-6-P synthase by mea...

Call: PRELUDIUM 5 , Panel: NZ2

Principal investigator: Aleksandra Miszkiel

Politechnika Gdańska, Wydział Chemiczny

Dynamics of binding of heterochromatin protein 1 (HP1) and its significance for DNA replication.

Call: OPUS 5 , Panel: NZ3

Principal investigator: dr Tytus Stefan Bernas

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Kinesin in motion relatively to tubulin - properties of solvation water and interactions between proteins

Call: SONATA 5 , Panel: NZ1

Principal investigator: dr Anna Natalia Kuffel

Politechnika Gdańska, Wydział Chemiczny

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Structure and properties of protein layers: from biomolecules to a functional layer (a combined experimental and simulat...

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Barbara Jachimska

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN