Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Computational insights into procathepsin maturation mediated by glycosaminoglycans.

2018/31/N/ST4/01677

Keywords:

molecular dynamics glycosaminoglycans protein-saccharide interactions molecular docking (pro)cathepsins

Descriptors:

  • ST4_15: Colloid chemistry
  • NZ1_3: Biophysics
  • NZ1_4: Structural biology

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Krzysztof Bojarski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 16 - announced on 2018-09-14

Amount awarded: 102 600 PLN

Project start date (Y-m-d): 2019-10-07

Project end date (Y-m-d): 2022-01-06

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Nod obliczeniowy (11 742 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Role of Oligosaccharide Chain Polarity in Protein-Glycsaominoglycan Interactions
    Authors:
    Krzysztof K. Bojarski, Sergey A. Samsonov
    Academic press:
    Journal of Chemical Information and Modeling (rok: 2021, tom: 61(1), strony: 455-466), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jcim.0c01402 - link to the publication
  2. Role of Glycosaminoglycans in Procathepsin B Maturation: Molecular Mechanism Elucidated by a Computational Study
    Authors:
    Krzysztof K. Bojarski, Agnieszka S. Karczyńska, Sergey A. Samsonov
    Academic press:
    Journal of Chemical Information and Modeling (rok: 2020, tom: 60(4), strony: 2247-2256), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jcim.0c00023 - link to the publication
  3. The abnormal accumulation of heparan sulfate in patients with mucopolysaccharidosis prevents the elastolytic activity of cathepsin V
    Authors:
    Thibault Chazeirat, Sophie Denamur, Krzysztof K. Bojarski, Pierre-Marie Andrault, Damien Sizaret, Fuming Zhang, Ahlame Saidi, Marine Tardieu, Robert J. Linhardt, François Labarthe, Dieter Brömme, Sergey A. Samsonov, Gilles Lalmanach, Fabien Lecaille
    Academic press:
    Carbohydrate Polymers (rok: 2021, tom: 253, strony: 117261), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.carbpol.2020.117261 - link to the publication

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