Projects funded by the NCN

Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr hab. Grażyna Leszczyńska

Politechnika Łódzka

Genetic and epigenetic fundamentals of cerebral vasospasm after aneurysmal subarachnoid hemorrhage

Call: PRELUDIUM 20 , Panel: NZ2

Principal investigator: Tomasz Klepinowski

Pomorski Uniwersytet Medyczny w Szczecinie

Nucleotide sugar transporters as organizing centers of glycosylation-related macromolecular complexes

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr Dorota Maszczak-Seneczko

Uniwersytet Wrocławski, Wydział Biotechnologii

Genetic variation of Scots pine ecotypes in Poland and its evolutionary and forest management implications following env...

Call: OPUS 19 , Panel: NZ9

Principal investigator: prof. Witold Wachowiak

Instytut Dendrologii Polskiej Akademii Nauk

Chemical architecture of fluorinated nucleoside dimers containing 1,2,3-triazole linker of potential use in molecular bi...

Call: SONATA 15 , Panel: NZ7

Principal investigator: dr Dagmara Baraniak

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Hsp70 and its cochaperones in protein recovery from aggregates

Call: OPUS 18 , Panel: NZ1

Principal investigator: prof. Krzysztof Liberek

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

The use of evolutionary patterns in the optimization of chemotherapy of tuberculosis

Call: SONATA BIS 9 , Panel: NZ6

Principal investigator: dr Alina Minias

Instytut Biologii Medycznej Polskiej Akademii Nauk

mRNA 5' end methylation status: towards deeper understanding of biological role and identification of synthetic mimics

Call: OPUS 17 , Panel: ST4

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Fotochemistry and Photophysics of Thiated Prebiotic Precursors of Nucleotides

Call: PRELUDIUM 17 , Panel: ST4

Principal investigator: Mikołaj Janicki

Politechnika Wrocławska

Spatio-temporal dynamics of genome-wide diversity of Fagus sylvatica

Call: BEETHOVEN LIFE 1 , Panel: NZ2

Principal investigator: prof. Jarosław Burczyk

Uniwersytet Kazimierza Wielkiego, Wydział Nauk Biologicznych

A new gereration of anticancer pronucleotides

Call: OPUS 1 , Panel: NZ4

Principal investigator: prof. Jacek Stawiński

Instytut Chemii Bioorganicznej PAN

Exploring second generation of nucleotide analogues containing phosphoranesulfen- or phosphoraneselenamides as new struc...

Call: PRELUDIUM 16 , Panel: ST5

Principal investigator: dr Justyna Gołębiewska

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

Synthesis and characterization of new molecular probes for monitoring activity of enzymes associated with RNA decapping ...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Biochemical bases of ectopic calcification of skeletal muscles in animal model of Duchenne muscular dystrophy (mdx mice)

Call: OPUS 15 , Panel: NZ4

Principal investigator: prof. Krzysztof Zabłocki

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Małgorzata Artymowicz

Gdański Uniwersytet Medyczny, Wydział Farmacutyczny

Why Nature introduced selenium to wobble nucleosides in transfer RNA?

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Barbara Nawrot

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Purinergic signaling as important regulator of hematopoietic system

Call: OPUS 15 , Panel: NZ4

Principal investigator: prof. Mariusz Ratajczak

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Functional glycol nucleic acid (fun-GNA) nucleosides, nucleotides and oligos: synthesis and properties

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Konrad Kowalski

Uniwersytet Łódzki, Wydział Chemii

mIHF, a unique mycobacterial nucleoid associated protein and its role in chromosome organization and gene expression

Call: SONATINA 2 , Panel: NZ1

Principal investigator: dr Joanna Hołówka

Uniwersytet Wrocławski, Wydział Biotechnologii

Revision of migration-selection patterns in Scots pine (Pinus sylvestris L.) using novel genomic approaches.

Call: OPUS 14 , Panel: NZ9

Principal investigator: prof. Witold Wachowiak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Analysis of cooperation of SLC35A3, SLC35B4 and SLC35D2 proteins in UDP-N-acetylglucosamine distribution in mammalian ce...

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: Bożena Szulc

Uniwersytet Wrocławski, Wydział Biotechnologii

The role of extracellular ATP fraction in induction of epithelial-mesenchymal transition - studies using analogs of nucl...

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Róża Pawłowska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Błażej Wojtczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Structural and mechanistic studies of bacterial DNA repair

Call: MAESTRO 9 , Panel: NZ1

Principal investigator: prof. Marcin Nowotny

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

The influence of impairment of extracellular nucleoside and nucleotide signaling on synaptic structure and function in a...

Call: OPUS 13 , Panel: NZ4

Principal investigator: dr hab. Agata Adamczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Varification of hypothesis connected with domestication of dog (Canis familiaris) using SNP genotyping

Call: OPUS 1 , Panel: NZ8

Principal investigator: prof. Wiesław Bogdanowicz

Muzeum i Instytut Zoologii PAN

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Sochacka

Politechnika Łódzka, Wydział Chemiczny

Investigating the biological role of 5' nucleotidases cN-IIIA and cN-IIIB in mRNA degradation and their terapeutic signi...

Call: SONATINA 1 , Panel: NZ1

Principal investigator: dr Dorota Kubacka

Uniwersytet Warszawski, Wydział Fizyki

Adaptations of cardiac myocyte energy metabolism in atherosclerosis - implications for pathology and therapeutic strateg...

Call: OPUS 12 , Panel: NZ4

Principal investigator: dr hab. Ryszard Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Development of HTS method based on fluorescently labelled guanosine analogues: novel route for RNA (guanosine-N7)-methyl...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Renata Kasprzyk

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Effect of single nucleotide polymorphism (SNP) in the human chorionic gonadotropin beta subunit gene on its expression i...

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr Mirosław Andrusiewicz

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Nauk o Zdrowiu

Application of LCMS to quantitative analysis of composition of in vitro transcribed RNAs containing chemically modified ...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Dominika Strzelecka

Uniwersytet Warszawski, Wydział Fizyki

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Magdalena Materna

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

In search of novel functions for SLC35A2 protein

Call: SONATA 12 , Panel: NZ3

Principal investigator: dr Dorota Maszczak-Seneczko

Uniwersytet Wrocławski, Wydział Biotechnologii

Reversal of heart failure during mechanical support of left ventricular function - role of nucleotides and energetics in...

Call: HARMONIA 8 , Panel: NZ4

Principal investigator: dr hab. Ryszard Smoleński

Gdański Uniwersytet Medyczny, Wydział Lekarski

Genomics of hybridization, adaptive variation and demography in hybrid zones of closely related pine species (genus Pinu...

Call: OPUS 1 , Panel: NZ8

Principal investigator: dr hab. Witold Wachowiak

Instytut Dendrologii PAN

Determination of the influence of 5' end of RNA modifications and nucleotide or amino acid sequence on the electrostatic...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Urszula Budniak

Uniwersytet Warszawski, Wydział Chemii

Development of method based on fluorescence polarization for high affinity ligand searching toward m7G nucleotide bindin...

Call: PRELUDIUM 11 , Panel: ST4

Principal investigator: Anna Wojtczak

Uniwersytet Warszawski, Wydział Fizyki

Chemically modified mRNA for studies on cellular processes and therapeutic applications

Call: OPUS 11 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Fluorescent biosensors based on quantum dots and purines/pyrimidines - synthesis, characterization and potential applica...

Call: PRELUDIUM 11 , Panel: ST5

Principal investigator: Łucja Rodzik-Czałka

Uniwersytet Jagielloński, Wydział Fizyki, Astronomii i Informatyki Stosowanej

Molecular bases of a therapy of rare genetic diseases caused by impaired activity of nucleotide sugar transporters

Call: OPUS 11 , Panel: NZ5

Principal investigator: prof. Mariusz Olczak

Uniwersytet Wrocławski, Wydział Biotechnologii

Pro-nucleotides based on mRNA cap structure - synthesis, biological and biophysical evaluation

Call: SONATA 11 , Panel: ST5

Principal investigator: dr Karolina Piecyk

Uniwersytet Warszawski, Wydział Chemii

Chromatographic determination of nucleic acids (DNA, RNA) and their constituents (nucleosides, nucleotides, oligonuceoti...

Call: SONATA 1 , Panel: ST4

Principal investigator: dr Sylwia Studzińska

UNIWERSYTET MIKOŁAJA KOPERNIKA, Wydział Chemii, Katedra Chemii Środowiska i Bioanalityki

Mitochondrial nucleoside diphosphate kinase (NDPK) as a regulator of mitochondrial proton leak catalyzed by purine nucle...

Call: SONATA 10 , Panel: NZ3

Principal investigator: dr hab. Andrzej Woyda-Płoszczyca

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Jacek Stawiński

Instytut Chemii Bioorganicznej PAN

Purine salvage pathway enzymes as a target for pathogenic organisma lacking de novo purine synthesis -cas study of Helic...

Call: HARMONIA 7 , Panel: NZ1

Principal investigator: prof. Maria Bzowska

Uniwersytet Warszawski, Wydział Fizyki

Synthesis and evaluation of a novel toolkit for biology and biotechnology based on adenine nucleotides analogs

Call: SONATA BIS 5 , Panel: ST5

Principal investigator: dr hab. Joanna Kowalska

Uniwersytet Warszawski, Wydział Fizyki

Look at the mechanism of ovarian cancer cells response to adenine nucleosides modified with metallacarborane clusters wi...

Call: OPUS 9 , Panel: NZ3

Principal investigator: dr Katarzyna Bednarska

Instytut Biologii Medycznej PAN

Extracellular nucleotide gradients as regulators of glioma cell motility

Call: OPUS 9 , Panel: NZ3

Principal investigator: dr hab. Paweł Pomorski

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Antiviral activity of novel acyclic phosphonate nucleoside analogues containing the 1,2,3-triazole moiety

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr Iwona Głowacka

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny