Projects funded by the NCN

Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Maciej Walczak

Politechnika Wrocławska, Wydział Chemiczny

RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

Call: SONATA 1 , Panel: NZ1

Principal investigator: dr Katarzyna Pachulska-Wieczorek

Instytut Chemii Bioorganicznej PAN

Design and synthesis of selective and irreversible inhibitors of HAT protease.

Call: PRELUDIUM 5 , Panel: ST5

Principal investigator: Marcin Skoreński

Politechnika Wrocławska, Wydział Chemiczny

Phosphonic inhibitors of human neutrophil elastase in cancer therapy

Call: SONATA 5 , Panel: NZ4

Principal investigator: dr Łukasz Winiarski

Politechnika Wrocławska, Wydział Chemiczny

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Inhibition of activity tryptophan hydroxylase-1 - the new conception in the treatment of mineral and bone disorders in c...

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Krystyna Pawlak

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Inhibitory neurotransmitter GABA in the aging of nervous system

Call: OPUS 5 , Panel: NZ3

Principal investigator: dr Monika Liguz-Lęcznar

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Assessment of mechanisms of tumour necrosis factor alpha (TNF-alpha) inhibitors' action in rheumatoid arthritis female p...

Call: PRELUDIUM 5 , Panel: NZ5

Principal investigator: Anna Szeremeta

Śląski Uniwersytet Medyczny w Katowicach, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Synthesis and studies of reaction products of oxirane derivatives with the -NH-(C=)-Br functionality of heteroaromatic c...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: dr Marzena Baran

Uniwersytet Jagielloński-Collegium Medicum, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Extracellular proteolytic activity of human epithelium - role in the modulation of signal transduction.

Call: SYMFONIA 1 , Panel: NZ1

Principal investigator: prof. Jan Potempa

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

The role of neutral endopeptidase (NEP) and its inhibitor, sialorphin, in colon cancer cells biology.

Call: OPUS 4 , Panel: NZ3

Principal investigator: prof. Martyna Kandefer-Szerszeń

Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Łęgowska

Uniwersytet Gdański, Wydział Chemii

Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Roman Komor

Politechnika Śląska, Wydział Chemiczny

One-pot synthesis of O-2-isocepham and N-2-isocepham derivatives bearing retroamide/thioretroamide or phosphono/thiophos...

Call: PRELUDIUM 4 , Panel: NZ7

Principal investigator: Marta Schielmann

Politechnika Gdańska, Wydział Chemiczny

Theoretical model of SH2-dependent STAT1 dimerization as a novel tool to identify specific compounds of functional inhib...

Call: PRELUDIUM 4 , Panel: NZ2

Principal investigator: Małgorzata Szeląg

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Kinases of emerging relevance in cancer - structural characterization.

Call: SONATA BIS 2 , Panel: NZ1

Principal investigator: dr Grzegorz Dubin

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Synthesis and pharmacological properties of mono- di- and triheterocyclic azole derivatives as a hybrid receptor and PDE...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Maciej Pawłowski

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Search of novel multifunctional ligands targeting neurodegereneration processes.

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Barbara Malawska

Uniwersytet Jagielloński-Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

New chemical and biological properties of topoizomeraze I inhibitors alkylating DNA oligomers

Call: OPUS 4 , Panel: ST4

Principal investigator: prof. Lech Kozerski

Instytut Chemii Organicznej PAN

Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Monika Lewandowska-Goch

Uniwersytet Gdański, Wydział Chemii

In vitro/in vivo characteristics of hydrophilic matrix containing phosphodiesterase-5 inhibitors.

Call: SONATA 4 , Panel: NZ7

Principal investigator: dr Anna Krupa

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Cardioprotective effect of inhibitors of matrix metalloproteinase-2 (MMP-2) and inhibitors of posttanslational modificat...

Call: HARMONIA 3 , Panel: NZ3

Principal investigator: prof. Mieczysław Woźniak

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of inna...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Impact of combined therapy of non-steroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors on oxida...

Call: OPUS 3 , Panel: NZ5

Principal investigator: dr hab. Piotr Gałecki

Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski, Klinika Psychiatrii Dorosłych

Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: dr Mirosława Skupińska

Instytut Chemii Bioorganicznej PAN

Stilbene and stilbazole derivatives as potential cyclooxygenase-2 (COX-2) inhibitors with probable antitumor and chemopr...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: Miłosz Regulski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Stimulation of endogenous neurogenesis as a novel therapeutic strategy in neonatal hypoxic-ischemic brain injury.

Call: OPUS 3 , Panel: NZ3

Principal investigator: dr Małgorzata Nałęcz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The role of corticotropin releasing factor (CRF) in low and high anxiety rats, and teh iteraction between of the CRF sys...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr Anna Skórzewska

Instytut Psychiatrii i Neurologii

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some ...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Kinga Sałat

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

Call: OPUS 3 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Karolina Piecyk

Uniwersytet Warszawski, Wydział Chemii

The influence of metabolic pathway inhibitors on the development and quality of bovine embryos produced in vitro.

Call: OPUS 3 , Panel: NZ9

Principal investigator: dr hab. Dorota Cieślak

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Pattern-Specific Inhibitors (PSI) - introduction and basic characteristics of a new class of inhibitors that block recog...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Krzysztof Guzik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

Call: OPUS 2 , Panel: NZ9

Principal investigator: dr hab. Aleksandra Obrępalska-Stęplowska

Instytut Ochrony Roślin - Państwowy Instytut Badawczy

Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

Call: PRELUDIUM 2 , Panel: ST4

Principal investigator: Martyna Maszota-Zieleniak

Uniwersytet Gdański, Wydział Chemii

Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Marta Sosnowska

Uniwersytet Gdański, Wydział Chemii

Novel urease inhibitors as means to control ureolytic microbial pathogens

Call: OPUS 2 , Panel: NZ6

Principal investigator: dr Agnieszka Grabowiecka

POLITECHNIKA WROCŁAWSKA

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

POLITECHNIKA GDAŃSKA

Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Artur Świerczek

Uniwersytet Jagielloński, Collegium Medicum

Inhibitory Functional Networks in Addiction Development within Social Context - a Missing Piece of Puzzle

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr Marzena Stefaniuk

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Flozins as potential inhibitors of aortic stenosis progression in patients with concomitant type 2 diabetes: impact on v...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Natorska

Uniwersytet Jagielloński

Modulation of the N-glycosylation as a tool to improve the CAR-T immunotherapy efficacy

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Graczyk-Jarzynka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Magdalena Wujak

Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy