Projects funded by the NCN


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49 projects found matching your search criteria :

  1. Development of novel potential therapeutics in inflammatory bowel diseases based on nanoformulations employing senomodul...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: prof. Jakub Jerzy Fichna

    Uniwersytet Medyczny w Łodzi

  2. Light-induced photoreceptor morphological changes – Towards objective and impartial diagnostics in ophthalmology

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Humberto Couto Fernandes

    Instytut Chemii Fizycznej Polskiej Akademii Nauk, Międzynarodowe Centrum Badań Oka

  3. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  4. Evaluating the antibacterial activity of the bacteriophage protein targeting Staphylococcus aureus, including drug-resis...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Zuzanna Maria Kaźmierczak

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  5. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  6. Exposing unseen passages - towards identification of functional transient tunnels in protein structures

    Call: PRELUDIUM BIS 5 , Panel: NZ2

    Principal investigator: dr hab. Jan Brezovský

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  7. Optimization of coarse-grained molecular dynamics simulations for tunnel exploration of large proteins with buried activ...

    Call: PRELUDIUM 22 , Panel: NZ2

    Principal investigator: Nishita Mandal

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

  8. Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

    Call: PRELUDIUM 21 , Panel: NZ7

    Principal investigator: Kinga Maria Czarnota-Łydka

    Uniwersytet Jagielloński, Collegium Medicum

  9. Two-component preparations in the treatment of infections caused by pathogenic microorganisms

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Katarzyna Szałapata

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  10. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  11. Searching for the power of hormesis - Effects of silver nanoparticles, graphene oxide (GO), and GO-Ag composite on the f...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Reyhaneh Seyed Alian

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

  12. Assessment of changes in mitochondria and the activity of selected enzymes and mitochondrial proteins in freshwater shri...

    Call: PRELUDIUM 20 , Panel: NZ8

    Principal investigator: Anna - Ostróżka

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

  13. Hybrid human SUMO proteins for selective detection and labelling of SENP proteases

    Call: OPUS 21 , Panel: ST4

    Principal investigator: dr Wioletta Katarzyna Rut

    Politechnika Wrocławska

  14. Chiroptical properties of proteins and their complexes (CRISPR/Cas-RNA), and their relationship to biological activity

    Call: SONATINA 5 , Panel: ST4

    Principal investigator: dr Monika Anna Hałat

    Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Biotechnologii i Ogrodnictwa

  15. Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

    Call: OPUS 20 , Panel: NZ7

    Principal investigator: dr hab. Iwona Aniela Gabriel

    Politechnika Gdańska, Wydział Chemiczny

  16. Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Tomasz Marcin Wróbel

    Uniwersytet Medyczny w Lublinie

  17. Application of PROTAC strategy for controlling Rab geranylgeranyl transferase and Rab proteins

    Call: PRELUDIUM BIS 2 , Panel: ST4

    Principal investigator: dr hab. Katarzyna Magdalena Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  18. In search of adaptive strategies in obligatory predators - The immunological mechanisms in reared model spider species S...

    Call: OPUS 19 , Panel: NZ8

    Principal investigator: dr hab. Grażyna Iwona Wilczek

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

  19. Drug metabolizing enzymes (DMEs) in liver pathology, proteomic characteristics, transcriptional and epigenetic regulatio...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Marek Droździk

    Pomorski Uniwersytet Medyczny w Szczecinie

  20. Modern nanoparticle and model organism - a toxic relation? Physiological and cellular causes of developmental disorders ...

    Call: OPUS 19 , Panel: NZ7

    Principal investigator: prof. Maria Jadwiga Augustyniak

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

  21. Exploring the mechanisms of therapy-facilitated metastasis and CAAX proteins-processing enzymes in liver cancer

    Call: OPUS 19 , Panel: NZ4

    Principal investigator: dr Jarosław Marek Cisowski

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  22. Design and synthesis of proteolytically stable and cell permeable activators of human 20S proteasome and assessing their...

    Call: PRELUDIUM BIS 1 , Panel: NZ7

    Principal investigator: dr hab. Elżbieta - Jankowska

    Uniwersytet Gdański, Wydział Chemii

  23. Novel families of ADP-ribosyltransferases and proteins involved in ADP-ribosylation.

    Call: OPUS 17 , Panel: NZ2

    Principal investigator: dr hab. Krzysztof Piotr Pawłowski

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

  24. Novel, rationally designed modulators of glycosomal import of enzymes in Trypanosoma parasites

    Call: OPUS 16 , Panel: NZ7

    Principal investigator: prof. Maciej Filip Dawidowski

    Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

  25. Characterization of hydrolysates and peptides derived from oat kernels proteins in the context of their activity in dise...

    Call: PRELUDIUM 16 , Panel: NZ9

    Principal investigator: dr Monika Anna Pliszka

    Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Nauki o Żywności

  26. New derivatives of clopidogrel - enantioselective biosynthesis and antiplatelet activity in vitro

    Call: PRELUDIUM 14 , Panel: NZ7

    Principal investigator: Adam Edward Sikora

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

  27. Dual-function tail phage proteins- determination of the function and the mechanism of action towards (poly)saccharides

    Call: SONATA BIS 7 , Panel: NZ1

    Principal investigator: dr Ewa Brzozowska

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  28. Structure and function of anti-virulent phage origin enzymes active against ESKAPE pathogens

    Call: HARMONIA 9 , Panel: NZ1

    Principal investigator: prof. Zuzanna Drulis-Kawa

    Uniwersytet Wrocławski, Wydział Nauk Biologicznych

  29. The enzymes of RNA metabolism, PAP I and PNPase, as targets for new antimycobacterial drugs and their functional charact...

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Jarosław Dziadek

    Instytut Biologii Medycznej PAN

  30. Biomedical materials modification by proteolytic enzymes inhibitors

    Call: OPUS 13 , Panel: NZ7

    Principal investigator: prof. Anna Beata Jarosz-Wilkołazka

    Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Wydział Biologii i Biotechnologii

  31. Structural studies on inhibition mechanisms of enzymes belonging to USP family, which remove ubiquitin from eukaryotic p...

    Call: SONATINA 1 , Panel: NZ1

    Principal investigator: dr Marcin Jarosław Ziemniak

    Uniwersytet Warszawski, Wydział Chemii

  32. Solid phase microextraction-based universal analytical platform for assessment of in vitro generated metabolism

    Call: PRELUDIUM 12 , Panel: NZ7

    Principal investigator: Karol Paweł Jaroch

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

  33. Cytoplasmic enzymes of pathogenic fungi Candida spp. that moonlight as adhesins on the cell wall - structural determinan...

    Call: OPUS 12 , Panel: NZ6

    Principal investigator: prof. Andrzej Kozik

    Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

  34. Mechanism of interaction between carbon nanoparticles of diamond, graphene oxide and graphite and cytochrome P450 enzyme...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Barbara Agnieszka Strojny

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Nauk o Zwierzętach

  35. The influence of simultaneous inhibition of endocannabinoid degrading enzymes FAAH and MAGL by JZL195 on the cardiovascu...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Marek Toczek

    Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

  36. Multi-domain proteins with disordered linkers in cellulose decomposition and cell adhesion

    Call: OPUS 11 , Panel: NZ1

    Principal investigator: dr Bartosz Jan Różycki

    Instytut Fizyki PAN

  37. Impact of the engineered mono-dispersed Fe3O4@SiO2 nanoparticles on a fungal enzyme inhibition in vitro

    Call: PRELUDIUM 9 , Panel: NZ7

    Principal investigator: Ahmet Kertmen

    Politechnika Gdańska, Wydział Chemiczny

  38. Comparative mRNA expression, protein abundance and regulatory mechanisms of drug metabolising eznymes and transporters i...

    Call: OPUS 9 , Panel: NZ7

    Principal investigator: prof. Marek Droździk

    Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

  39. Synthesis, characteristics and activity of biopolymer-based modified magnetic nanoparticles as potential carriers for en...

    Call: OPUS 8 , Panel: NZ7

    Principal investigator: dr hab. Michał Piotr Marszałł

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

  40. Structural basis of biological properties of muscle fructose-1,6-bisphosphatase (FBPase) - a regulatory enzyme of glycon...

    Call: OPUS 5 , Panel: NZ1

    Principal investigator: prof. Andrzej Dżugaj

    Uniwersytet Wrocławski, Wydział Nauk Biologicznych

  41. Cross-talk between PXR and AR receptors in hormone-dependent cancers.

    Call: SONATA 5 , Panel: NZ7

    Principal investigator: dr Magdalena Niemira

    Politechnika Gdańska, Wydział Chemiczny

  42. Design of enzyme systems for the study of chiral drugs with the use of superparamagnetic nanoparticles as carriers for b...

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: dr Tomasz Siódmiak

    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy; Wydział Farmaceutyczny

  43. Influence of chlorpyrifos on the activity of enzymes responsible for the vitamin D3 synthesis in skin cells

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Krzysztof Bogumił Sawicki

    Instytut Medycyny Wsi im. Witolda Chodźki

  44. The role of the brain serotonergic system in the expression and activity of liver cytochrome P450.

    Call: PRELUDIUM 4 , Panel: NZ7

    Principal investigator: dr Marta Anna Rysz

    Instytut Farmakologii PAN

  45. Nanostructures in electrochemical biosensors and SERS indicators

    Call: OPUS 2 , Panel: ST4

    Principal investigator: dr hab. Barbara Jadwiga Pałys

    Uniwersytet Warszawski, Wydział Chemii

  46. Association between genetic polimorphisms in selected antioxidant enzymes genes and DNA repair genes and oxidative damag...

    Call: PRELUDIUM 2 , Panel: NZ7

    Principal investigator: Elżbieta Marta Olewińska

    Instytut Medycyny Pracy i Zdrowia Środowiskowego

  47. The optimal rate of cooling and protection against brain hyperferremia - as a potential therapy of neonatal asphyxia

    Call: OPUS 2 , Panel: NZ7

    Principal investigator: dr hab. Justyna Żaneta Rogalska

    Uniwersytet Mikołaja Kopernika, Wydział Biologii i Ochrony Środowiska

  48. The use of proteolytic enzymes isolated form nonconventional sources for obtaining biologically active peptides from mil...

    Call: OPUS 1 , Panel: NZ9

    Principal investigator: dr Anna Ewa Dąbrowska

    Uniwersytet Przyrodniczy we Wrocławiu, Wydział Nauk o Żywności

  49. Effects of ethylene glycol ethers on oxidative stress and key enzymes of glucose metabolism in some regions of the brain...

    Call: OPUS 1 , Panel: NZ7

    Principal investigator: prof. Bogusława Budziszewska

    Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny z Oddziałem Analityki Medycznej