Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Application of PROTAC strategy for controlling Rab geranylgeranyl transferase and Rab proteins

2020/39/O/ST4/01360

Keywords:

Rab GGTase Rab proteins prenylation phosphonocarboxylates degradation PROTAC

Descriptors:

  • ST4_8: Organic chemistry
  • ST4_9: Biological chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Łódzka, Wydział Chemiczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Katarzyna Magdalena Błażewska 

Number of co-investigators in the project: 2

Call: PRELUDIUM BIS 2 - announced on 2020-09-15

Amount awarded: 541 600 PLN

Project start date (Y-m-d): 2021-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1
    Authors:
    K. F. Suazo, J. Beˇlicˇek, G. L. Schey, S. A. Auger, A. M. Petre, L. Li, K. M. Błażewska, D. Kopecˇny, M. D. Distefano
    Academic press:
    RSC Chemical Biology (rok: 2023, tom: 4, strony: 913-925), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D3CB00089C - link to the publication
  2. Targeting reversible post-translational modifications with PROTACs: a focus on enzymes modifying protein lysine and arginine residues
    Authors:
    2. M. Pichlak, T. Sobierajski, K. M. Błażewska, E. Gendaszewska-Darmach
    Academic press:
    Journal of Enzyme Inhibition and Medicinal Chemistry (rok: 2023, tom: 38, strony: 2254012), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/14756366.2023.2254012 - link to the publication
  3. Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization
    Authors:
    Aleksandra Marchwicka, Daria Kamińska, Mohsen Monirialamdari, Katarzyna M Błażewska, Edyta Gendaszewska-Darmach
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 5424), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms23105424 - link to the publication
  4. Protein Prenyltransferases and Their Inhibitors: Structural and Functional Characterization
    Authors:
    Aleksandra Marchwicka, Daria Kamińska, Mohsen Monirialamdari, Katarzyna M Błażewska, Edyta Gendaszewska-Darmach
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 5424), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms23105424 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy