Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Drug metabolizing enzymes (DMEs) in liver pathology, proteomic characteristics, transcriptional and epigenetic regulation

2020/37/B/NZ7/01466

Keywords:

drug metabolizing enzymes liver pathology

Descriptors:

  • NZ7_014:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Droździk 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 1 087 740 PLN

Project start date (Y-m-d): 2021-02-15

Project end date (Y-m-d): 2025-08-14

Project duration:: 54 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (13)
  1. The reference liver – CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
    Authors:
    Kurzawski M., Szeląg-Pieniek S., Łapczuk-Romańska J., Wrzesiński M., Oswald S., Droździk M
    Academic press:
    Pharmacol. Rep. (rok: 2022, tom: 74, strony: 204-215), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00337-w - link to the publication
  2. Gene expression and protein abundance of hepatic drug metabolizing enzymes in liver pathology
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Szelag-Pieniek S, Post M, Skalski L, Kurzawski M, Oswald S
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1334), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13091334 - link to the publication
  3. A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking
    Authors:
    Gholizadeh M, Łapczuk-Romańska J, Post M, Komaniecka N, Mazlooman SR, Kaderali L, Droździk M
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7207), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24087207 - link to the publication
  4. The reference liver – CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
    Authors:
    Kurzawski M., Szeląg-Pieniek S., Łapczuk-Romańska J., Wrzesiński M., Oswald S., Droździk M
    Academic press:
    Pharmacol. Rep. (rok: 2022, tom: 74, strony: 204-215), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00337-w - link to the publication
  5. A Mixture Method for Robust Detection HCV Early Diagnosis Biomarker with ML Approach and Molecular Docking
    Authors:
    Gholizadeh M, Łapczuk-Romańska J, Post M, Komaniecka N, Mazlooman SR, Kaderali L, Droździk M
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 24, strony: 7207), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24087207 - link to the publication
  6. Gene expression and protein abundance of hepatic drug metabolizing enzymes in liver pathology
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Szelag-Pieniek S, Post M, Skalski L, Kurzawski M, Oswald S
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1334), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13091334 - link to the publication
  7. The reference liver – CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
    Authors:
    Kurzawski M., Szeląg-Pieniek S., Łapczuk-Romańska J., Wrzesiński M., Oswald S., Droździk M
    Academic press:
    Pharmacol. Rep. (rok: 2022, tom: 74, strony: 204-215), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00337-w - link to the publication
  8. Gene expression and protein abundance of hepatic drug metabolizing enzymes in liver pathology
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Szelag-Pieniek S, Post M, Skalski L, Kurzawski M, Oswald S
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1334), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13091334 - link to the publication
  9. The reference liver – CYP450 and UGT enzymes in healthy donor and metastatic livers: the impact of genotype
    Authors:
    Kurzawski M., Szeląg-Pieniek S., Łapczuk-Romańska J., Wrzesiński M., Oswald S., Droździk M
    Academic press:
    Pharmacol. Rep. (rok: 2022, tom: 74, strony: 204-215), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-021-00337-w - link to the publication
  10. Gene expression and protein abundance of hepatic drug metabolizing enzymes in liver pathology
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Szelag-Pieniek S, Post M, Skalski L, Kurzawski M, Oswald S
    Academic press:
    Pharmaceutics (rok: 2021, tom: 13, strony: 1334), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics13091334 - link to the publication
  11. Protein abundance of drug metabolizing enzymes in human hepatitis C livers
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Skalski L., Szelag-Pieniek S., Post M., Parus A., Syczewska M., Kurzawski M., Oswald S.
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 4543), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24054543 - link to the publication
  12. Protein abundance of drug metabolizing enzymes in human hepatitis C livers
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Skalski L., Szelag-Pieniek S., Post M., Parus A., Syczewska M., Kurzawski M., Oswald S.
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 4543), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24054543 - link to the publication
  13. Protein abundance of drug metabolizing enzymes in human hepatitis C livers
    Authors:
    Drozdzik M., Lapczuk-Romanska J., Wenzel Ch., Skalski L., Szelag-Pieniek S., Post M., Parus A., Syczewska M., Kurzawski M., Oswald S.
    Academic press:
    Int. J. Mol. Sci. (rok: 2023, tom: 24, strony: 4543), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24054543 - link to the publication

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