Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cytoplasmic enzymes of pathogenic fungi Candida spp. that moonlight as adhesins on the cell wall - structural determinants of the novel function

2016/23/B/NZ6/00089

Keywords:

candidiasis adhesion adhesins moonlighting proteins non-conventional secretion extracellular matrix posttranslational modifications surface plasmon resonance mass spectrometry chemical cross-linking

Descriptors:

  • NZ6_7: Mycology
  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Kozik 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 265 000 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2021-07-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora laminarna klasy Biohazard (30 000 PLN)
  2. Termostatowany inkubator z wytrząsarką, z chłodzeniem, sterowany mikroprocesorowo (45 000 PLN)
  3. Inkubator od hodowli komórek (30 000 PLN)
  4. Automatyczny system do szybkiej chromatografii białek (185 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Moonlighting Proteins at the Candidal Cell Surface
    Authors:
    Dorota Satala, Jystyna Karkowska-Kuleta, Aleksandra Zelazna, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    Microorganisms (rok: 2020, tom: 8, strony: 1046), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms8071046 - link to the publication
  2. Als3-mediated attachment of enolase on the surface of Candida albicans cells regulates their interactions with host proteins
    Authors:
    Justyna Karkowska-Kuleta, Ewelina Wronowska, Dorota Satala, Marcin Zawrotniak, Grazyna Bras, Andrzej Kozik, Angela H. Nobbs, Maria Rapala-Kozik
    Academic press:
    Cellular Microbiology (rok: 2021, tom: 23, strony: e13297), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/cmi.13297 - link to the publication
  3. Moonlighting proteins are variably exposed at the cell surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under certain growth conditions
    Authors:
    Justyna Karkowska-Kuleta, Dorota Satala, Oliwia Bochenska, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    BMC Microbiology (rok: 2019, tom: 19, strony: 149), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-019-1524-5 - link to the publication
  4. Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins
    Authors:
    Satala D, Satala G, Zawrotniak M, Kozik A
    Academic press:
    BMC Microbiology (rok: 2021, tom: 21, strony: 199), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-021-02235-w - link to the publication
  5. Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
    Authors:
    Justyna Karkowska-Kuleta, Kamila Kulig, Elzbieta Karnas, Ewa Zuba-Surma, Olga Woznicka, Elzbieta Pyza, Patryk Kuleta, Artur Osyczka, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1722), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071722 - link to the publication
  6. Structural Insights into the Interactions of Candidal Enolase with Human Vitronectin, Fibronectin and Plasminogen
    Authors:
    Dorota Satala, Grzegorz Satala, Justyna Karkowska-Kuleta, Michal Bukowski, Anna Kluza, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7843), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217843 - link to the publication
  7. Towards understanding the novel adhesin function of Candida albicans phosphoglycerate mutase at the pathogen cell surface: some structural analysis of the interactions with human host extracellular matrix proteins
    Authors:
    Satala D, Zelazna A, Satala G, Bukowski M, Zawrotniak M, Rapala-Kozik M, Kozik A
    Academic press:
    Acta Biochimica Polonica (rok: 2021, tom: 68, strony: 515-525), Wydawca: Polskie Towarzystwo Biochemiczne i Polska Akademia Nauk
    Status:
    Published
    DOI:
    10.18388/abp.2020_5959 - link to the publication

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