Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Cytoplasmic enzymes of pathogenic fungi Candida spp. that moonlight as adhesins on the cell wall - structural determinants of the novel function

2016/23/B/NZ6/00089

Keywords:

candidiasis adhesion adhesins moonlighting proteins non-conventional secretion extracellular matrix posttranslational modifications surface plasmon resonance mass spectrometry chemical cross-linking

Descriptors:

  • NZ6_7: Mycology
  • NZ1_10: Microbiology
  • NZ1_2: Biochemistry

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Kozik 

Number of co-investigators in the project: 6

Call: OPUS 12 - announced on 2016-09-15

Amount awarded: 1 265 000 PLN

Project start date (Y-m-d): 2017-07-25

Project end date (Y-m-d): 2021-07-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Inkubator od hodowli komórek (30 000 PLN)
  2. Komora laminarna klasy Biohazard (30 000 PLN)
  3. Termostatowany inkubator z wytrząsarką, z chłodzeniem, sterowany mikroprocesorowo (45 000 PLN)
  4. Automatyczny system do szybkiej chromatografii białek (185 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Candida albicans and Candida glabrata triosephosphate isomerase - a moonlighting protein that can be exposed on the candidal cell surface and bind to human extracellular matrix proteins
    Authors:
    Satala D, Satala G, Zawrotniak M, Kozik A
    Academic press:
    BMC Microbiology (rok: 2021, tom: 21, strony: 199), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-021-02235-w - link to the publication
  2. Characteristics of Extracellular Vesicles Released by the Pathogenic Yeast-Like Fungi Candida glabrata, Candida parapsilosis and Candida tropicalis
    Authors:
    Justyna Karkowska-Kuleta, Kamila Kulig, Elzbieta Karnas, Ewa Zuba-Surma, Olga Woznicka, Elzbieta Pyza, Patryk Kuleta, Artur Osyczka, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 1722), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9071722 - link to the publication
  3. Moonlighting proteins are variably exposed at the cell surfaces of Candida glabrata, Candida parapsilosis and Candida tropicalis under certain growth conditions
    Authors:
    Justyna Karkowska-Kuleta, Dorota Satala, Oliwia Bochenska, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    BMC Microbiology (rok: 2019, tom: 19, strony: 149), Wydawca: BMC Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-019-1524-5 - link to the publication
  4. Structural Insights into the Interactions of Candidal Enolase with Human Vitronectin, Fibronectin and Plasminogen
    Authors:
    Dorota Satala, Grzegorz Satala, Justyna Karkowska-Kuleta, Michal Bukowski, Anna Kluza, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 7843), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21217843 - link to the publication
  5. Als3-mediated attachment of enolase on the surface of Candida albicans cells regulates their interactions with host proteins
    Authors:
    Justyna Karkowska-Kuleta, Ewelina Wronowska, Dorota Satala, Marcin Zawrotniak, Grazyna Bras, Andrzej Kozik, Angela H. Nobbs, Maria Rapala-Kozik
    Academic press:
    Cellular Microbiology (rok: 2021, tom: 23, strony: e13297), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/cmi.13297 - link to the publication
  6. Towards understanding the novel adhesin function of Candida albicans phosphoglycerate mutase at the pathogen cell surface: some structural analysis of the interactions with human host extracellular matrix proteins
    Authors:
    Satala D, Zelazna A, Satala G, Bukowski M, Zawrotniak M, Rapala-Kozik M, Kozik A
    Academic press:
    Acta Biochimica Polonica (rok: 2021, tom: 68, strony: 515-525), Wydawca: Polskie Towarzystwo Biochemiczne i Polska Akademia Nauk
    Status:
    Published
    DOI:
    10.18388/abp.2020_5959 - link to the publication
  7. Moonlighting Proteins at the Candidal Cell Surface
    Authors:
    Dorota Satala, Jystyna Karkowska-Kuleta, Aleksandra Zelazna, Maria Rapala-Kozik, Andrzej Kozik
    Academic press:
    Microorganisms (rok: 2020, tom: 8, strony: 1046), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms8071046 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy