Projects funded by the NCN

Impact of cytostatic drugs present in the environment on Gram-negative bacteria: mechanisms of adaptation and implicatio...

Call: PRELUDIUM 23 , Panel: NZ9

Principal investigator: Adam Grzywaczyk

Politechnika Poznańska

Using DNA methylation markers and epigenetic clocks as an innovative tool to assess health, risk indicators, and manage ...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Ewelina Maria Pośpiech

Pomorski Uniwersytet Medyczny w Szczecinie

Role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to imatinib

Call: OPUS 2 , Panel: NZ2

Principal investigator: prof. Janusz Błasiak

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Genomic analysis of invasive vancomycin-resistant Enterococcus faecium of VanA phenotype from intensive-care units in Po...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Ewa Nina Wardal

Narodowy Instytut Leków

Optogenetic and chemogenetic identification of brain circuits and cellular mechanisms underlying antidepressants resista...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii PAN

Metallacarborane-peptide amphiphiles as a new strategy in the fight against multidrug-resistant Gram-negative bacteria

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Krzysztof Konrad Fink

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Organometallic (Fe, Ru, Ir, Os) phospho-inducers of drug-resistant cancer cells' ferroptosis

Call: OPUS 26 , Panel: ST4

Principal investigator: dr hab. Urszula Katarzyna Komarnicka

Uniwersytet Wrocławski, Wydział Chemii

"One step to game changer": combined antimicrobial therapy based on AI and nanotechnology to combat challenging diabetes...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Barbara Ewa Pucelik

Sieć Badawcza ŁUKASIEWICZ - Krakowski Instytut Technologiczny

Evaluating the antibacterial activity of the bacteriophage protein targeting Staphylococcus aureus, including drug-resis...

Call: SONATA 19 , Panel: NZ7

Principal investigator: dr Zuzanna Maria Kaźmierczak

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Click chemistry in microfluidic channels for the construction of nanomaterials against drug-resistant microbes.

Call: PRELUDIUM BIS 5 , Panel: ST11

Principal investigator: dr hab. Marek Brzeziński

Centrum Badań Molekularnych i Makromolekularnych PAN

One health surveillance approach on marine mammal, marine environmental and human antimicrobial resistance on the North ...

Call: JPIAMR ACTION Call 2023 , Panel: NZ7

Principal investigator: dr Iwona Joanna Pawliczka vel Pawlik

Uniwersytet Gdański, Wydział Oceanografii i Geografii

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej PAN

Inactivation of intracellular Staphylococcus aureus and staphylococcal enterotoxins with photoactivated compounds in mod...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Joanna Nakonieczna

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

Call: OPUS 25 , Panel: NZ3

Principal investigator: dr Daria Paulina Zdżalik-Bielecka

Uniwersytet Warszawski, Wydział Biologii

Chiral hybrids of quinones and quinols with double anticancer and antimicrobial activity against drug-resistant pathogen...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Ryszard Józef Ostaszewski

Instytut Chemii Organicznej Polska Akademia Nauk

Bis(benzosiloxaboroles) as a new class of potential antibiotics - a perspective solution to growing problem of antimicro...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Krzysztof Nowicki

Politechnika Warszawska, Wydział Chemiczny

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Maciej Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

unESKAPEable. Innovative antibiotics leads based on bifunctionalsed metallacarboranes to combat ESKAPE pathogens.

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Jakub Cebula

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Conjugates of peptide nucleic acids with aminoglycosides and fluoroquinolones as a novel strategy to target multi-drug r...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Izabela Siekierska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Unveiling the molecular signature underlying resistance to CD19 CAR-T therapy in malignant cells.

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marta Krawczyk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Assessment of the risk of tolerance, resistance and co-selection under various stress conditions in Escherichia coli.

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Aleksandra Małgorzata Rapacka-Zdończyk

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Plant bacterial endophytes as an important antibiotic-resistance dissemination vector

Call: SONATA 18 , Panel: NZ9

Principal investigator: dr Magdalena Marta Zalewska

Uniwersytet Warszawski, Wydział Biologii

Three-phase drug carriers - design towards a prolonged release, development of a transport model and its verification. C...

Call: PRELUDIUM BIS 4 , Panel: ST8

Principal investigator: prof. Anna Trusek

Politechnika Wrocławska

Brain-targeted β‐hydroxy-β‐methylbutyrate administration in the prevention of insulin resistance development in the hypo...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Elżbieta Supruniuk

Uniwersytet Medyczny w Białymstoku

Regulatory network and interactome of inner membrane drug/metabolite transporters in bacteria – implications for physiol...

Call: OPUS 23 , Panel: NZ2

Principal investigator: dr hab. Aneta Agnieszka Bartosik

Instytut Biochemii i Biofizyki PAN

Role of the PARP1/HPF1 complex in the conferring of resistance to doxorubicin in triple negative breast cancer

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Magdalena Alicja Strachowska

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Role of natural products in overcoming drug resistance in Mycobacterium tuberculosis

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Elwira Zofia Sieniawska

Uniwersytet Medyczny w Lublinie

Effect of exercise training on muscle regenerative activity in hemodialysis patients

Call: OPUS 2 , Panel: NZ7

Principal investigator: dr hab. Wioletta Dziubek-Rogowska

AKADEMIA WYCHOWANIA FIZYCZNEGO WE WROCŁAWIU

Reserved antibiotics and critical priority pathogens in hospital wastewater as an indicator of sanitary-epidemiological ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Ewa Korzeniewska

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Geoinżynierii

The use of genetic analysis of liquid biopsy for predicting and monitoring ofresponse to therapies and tumor evolution i...

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Magdalena Olbryt

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

The role of Candida albicans' plasma membrane sphingolipids in the potentially new mechanism of drug resistance and in t...

Call: OPUS 22 , Panel: NZ1

Principal investigator: dr hab. Anna Janina Krasowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

Call: OPUS 22 , Panel: NZ5

Principal investigator: dr hab. Carlo Vascotto

Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

Nanospectroscopic imaging of native biological membranes: Is the cell membrane the key for understanding the mechanism o...

Call: SONATA BIS 11 , Panel: ST4

Principal investigator: dr Katarzyna Pogoda

Instytut Fizyki Jądrowej im. Henryka Niewodniczańskiego PAN

Interventions to control the dynamics of antimicrobial resistance from chickens through the environment

Call: JPIAMR-ACTION Call 2021 , Panel: NZ7

Principal investigator: dr Marta Kuźmińska-Bajor

Uniwersytet Przyrodniczy we Wrocławiu

Ionophore coccidiostats: risk of CO-selection of antimicrobial resistance - Clinical impact and intervention strategies

Call: JPIAMR-ACTION Call 2021 , Panel: NZ7

Principal investigator: dr Jowita Samanta Niczyporuk

Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy

Specific Targeting of Antimicrobial Resistant Strains in situ using Targeted-Antibacterial-Plasmids

Call: JPIAMR-ACTION Call 2021 , Panel: NZ7

Principal investigator: dr Anna Marzec-Grządziel

Instytut Uprawy Nawożenia i Gleboznawstwa - Państwowy Instytut Badawczy

RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Mikołaj Czajkowski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Analysis of semaphorin 3 (SEMA3), protocadherin 9 (PCDH9) and S 100 calcium binding proteinA3 (S100A3) expression in pro...

Call: OPUS 21 , Panel: NZ5

Principal investigator: dr hab. Radosław Januchowski

Uniwersytet Zielonogórski, Collegium Medicum

Evaluation of NOTCH1- and NOTCH3-dependent anticancer drug resistance in a 2D and 3D model of Head and Neck Squamous Cel...

Call: PRELUDIUM 20 , Panel: NZ5

Principal investigator: dr Joanna Elżbieta Kałafut

Uniwersytet Medyczny w Lublinie

Relationship between ATPase activity stimulation and transport - the case of selective Medicago truncatula ABCG transpor...

Call: PRELUDIUM 20 , Panel: NZ1

Principal investigator: dr Konrad Mateusz Pakuła

Instytut Chemii Bioorganicznej PAN

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Karolina Pogorzelska

Narodowy Instytut Leków

Evaluation of contamination of Vistula River near Warsaw by pharmaceuticaly active compounds and metabolites

Call: OPUS 2 , Panel: NZ7

Principal investigator: prof. Grzegorz Leszek Nałęcz-Jawecki

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

AXL receptor signaling in cancer cell growth and drug resistance

Call: OPUS 20 , Panel: NZ3

Principal investigator: prof. Marta Elżbieta Miączyńska

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Propolis and polyphenols derived from this product as potential antifungal agents

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Piotr Szweda

Politechnika Gdańska

The role of vitamin D receptor in 5-fluorouracil responsiveness of colorectal cancer cells

Call: SONATA 16 , Panel: NZ5

Principal investigator: dr Magdalena - Milczarek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Novel dual CYP17A1 and AKR1C3 inhibitors for studying the mechanism of resistance in prostate cancer

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Tomasz Marcin Wróbel

Uniwersytet Medyczny w Lublinie

Make an old drug great again – isoniazid/rifamycin-boron clusters conjugates – synthesis and antitubercular activity....

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Bogusława Olejniczak

Instytut Biologii Medycznej PAN

Epidemiology and rapid spread of antimicrobial resistance amongAcinetobacter spp. strains in hospital units - analysis u...

Call: PRELUDIUM BIS 2 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Chmielarczyk

Uniwersytet Jagielloński, Collegium Medicum