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Information on the principal investigator and host institution

Information of the project and the call

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Role of mitochondrial DNA damage and repair in the resistance of BCR/ABL-expressing cells to imatinib

2011/03/B/NZ2/01396

Keywords:

mitochondrial DNA DNA damage DNA repair imatinib BCR/ABL drug resistance chronic myelogenous leukemia

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ2_1: Molecular genetics

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Błasiak 

Number of co-investigators in the project: 10

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 436 800 PLN

Project start date (Y-m-d): 2012-08-13

Project end date (Y-m-d): 2015-08-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  1. Reactive oxygen species and mitochondrial DNA damage and repair in BCR-ABL1 cells resistant to imatinib
    Authors:
    Blasiak J, Hoser G, Bialkowska-Warzecha J, Pawlowska E, Skorski T
    Academic press:
    BioResearch Open Access (rok: 2015, tom: 4,1, strony: 334-342), Wydawca: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/biores.2015.0022 - link to the publication
  2. Role of mitochondria in carcinogenesis
    Authors:
    Tokarz P, Blasiak J
    Academic press:
    Acta Biochim Pol (rok: 2014, tom: 61, strony: 671-678), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Doxorubicin differentially induces apoptosis, expression of mitochondrial apoptosis-related genes and mitochondrial potential in BCR-ABL1-expressing cells sensitive and resistant to imatinib
    Authors:
    Synowiec E, Hoser G, Wójcik K, Pawlowska E, Skorski T, Blasiak J
    Academic press:
    BioMed Res Int (rok: 2015, tom: 2015, strony: 673512), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2738 - link to the publication
  4. Mitochondrial mutagenesis in BCR-ABL1-expressing cells sensitive and resistant to imatinib
    Authors:
    Blasiak J, Hoser G, Bialkowska-Warzecha J, Pawlowska E, Skorski T
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: ), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Accepted for publication
    DOI:
    Brak - link to the publication
  5. DNA repair – a double sword in the genomic stability of cancer cells – the case of chronic myeloid leukemia
    Authors:
    Pawlowska E, Blasiak J
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16, strony: 27535-27549), Wydawca: MDPI AG Basel
    Status:
    Published
    DOI:
    10.3390/ijms - link to the publication
  6. Role of anti-apoptotic pathways activated by BCR/ABL in the resistance of chronic myeloid leukemia cells to tyrosine kinase inhibitors
    Authors:
    Danisz K, Błasiak J
    Academic press:
    Acta Biochimica Polonica (rok: 2013, tom: 60, strony: 503-514), Wydawca: The Journal of the Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Status:
    Published
    DOI:
    brak - link to the publication
  7. The role of mitochondrial DNA damage and repair in resistance of BCR/ABL-expressing to tyrosine kinase inhibitors
    Authors:
    Głowacki S, Synowiec E, Błasiak J
    Academic press:
    International Journal of Moecularl Sciences (rok: 2013, tom: 14, strony: 16348-16364), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms140816348 - link to the publication
  8. Therapy of Chronic Myeloid Leukemia: Twilight of the Imatinib Era?
    Authors:
    Trela E, Głowacki S, Błasiak J
    Academic press:
    ISRN Oncology (rok: 2014, tom: Art ID 596483, strony: 9 pages), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2014/596483 - link to the publication
  9. UV differentially induces oxidative stress, DNA damage and apoptosis in BCR-ABL1-positive cells sensitive and resistant to imatinib
    Authors:
    Synowiec E, Hoser G, Wójcik K, Pawlowska E, Skorski T, Blasiak J
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16, strony: 18111-18128), Wydawca: MDPI AG Basel
    Status:
    Published
    DOI:
    10.3390/ijms160818111 - link to the publication
  10. Znaczenie modyfikacji epigenetycznych w patogenezie białaczek
    Authors:
    Sylwester Głowacki, Janusz Błasiak
    Academic press:
    Acta Haematologica Polonica (rok: 2013, tom: 44, strony: 48-57), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.achaem.2013.02.002 - link to the publication

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