Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of cancer stem cells in extracellular matrix production and drug resistance in ovarian cancer

2016/22/E/NZ5/00381

Keywords:

ovarian cancer multidrug resistance cytostatics cancer stem cells extracellular matrix collagens three-dimensional (3D) cell culture spheroids

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ4_4: Pathophysiology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Radosław Januchowski 

Number of co-investigators in the project: 4

Call: SONATA BIS 6 - announced on 2016-06-15

Amount awarded: 1 467 000 PLN

Project start date (Y-m-d): 2017-05-18

Project end date (Y-m-d): 2022-05-17

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Stanowisko komputerowe z drukarką (24 000 PLN)
  2. Dyski twarde.

Information in the final report

  • Publication in academic press/journals (12)
  1. Drug Resistance Evaluation in Novel 3D In Vitro Model
    Authors:
    Marta Nowacka, Karolina Sterzynska , Malgorzata Andrzejewska , Michal Nowicki and Radoslaw Januchowski
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2021, tom: 138, strony: E111536, 15 stron), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biopha.2021.111536 - link to the publication
  2. Effect of ALDH1A1 Gene Knockout on Drug Resistance in Paclitaxel and Topotecan Resistant Human Ovarian Cancer Cell Lines in 2D and 3D Model
    Authors:
    Marta Nowacka, Barbara Ginter-Matuszewska, Monika Swierczewska, Karolina Sterzyńska, Michał Nowicki and Radosław Januchowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: E3036, 23 strony), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23063036 - link to the publication
  3. The Role of Matrix Gla Protein (MGP) Expression in Paclitaxel and Topotecan Resistant Ovarian Cancer Cell Lines.
    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Andrzejewska M, Rusek D, Sobkowski M, Kędzia W, Brązert J, Nowicki M, Januchowski R
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: E2901, 17 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19102901 - link to the publication
  4. The Profile of MicroRNA Expression and Potential Role in the Regulation of Drug-Resistant Genes in Cisplatin- and Paclitaxel-Resistant Ovarian Cancer Cell Lines
    Authors:
    Dominika Kazmierczak, Karol Jopek, Karolina Sterzynska, Michal Nowicki, Marcin Rucinski and Radoslaw Januchowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: E526, 21 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23010526 - link to the publication
  5. Mutual Expression of ALDH1A1, LOX, and Collagens in Ovarian Cancer Cell Lines as Combined CSCs- and ECM-Related Models of Drug Resistance Development.
    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Nowacka M, Kaźmierczak D, Andrzejewska M, Rusek D, Brązert M, Brązert J, Nowicki M, Januchowski R.
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(1), strony: E54, 21 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20010054. - link to the publication
  6. Role of miRNA in ovarian cancer diagnosis, prognosis and development of drug resistance
    Authors:
    Kaźmierczak D, Sterzyńska K, Januchowski R
    Academic press:
    Postępy Biologii Komórki (rok: 2021, tom: 48, strony: 271-282), Wydawca: FUNDACJA BIOLOGII KOMÓRKI I BIOLOGII MOLEKULARNEJ
    Status:
    Published
    DOI:
    brak - link to the publication
  7. The profile of microRNA expression and potential role in the regulation of drug-resistant genes in doxorubicin and topotecan resistant ovarian cancer cell lines.
    Authors:
    Stasiak Piotr, Kaźmierczak Dominika, Jopek Karol, Nowicki Michał, Ruciński Marcin, Januchowski Radosław
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: E5846, 25 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23105846 - link to the publication
  8. Expression of Osteoblast-Specific Factor 2 (OSF-2, Periostin) Is Associated with Drug Resistance in Ovarian Cancer Cell Lines
    Authors:
    Sterzyńska K, Kaźmierczak D, Klejewski A, Świerczewska M, Wojtowicz K, Nowacka M, Brązert J, Nowicki M, Januchowski R
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(16), strony: E3927, 15 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20163927. - link to the publication
  9. Myotilin, a New Topotecan Resistant Protein in Ovarian Cancer Cell Lines.
    Authors:
    Sterzyńska K, Klejewski A, Wojtowicz K, Świerczewska M, Nowicki M, Brązert J, Januchowski R
    Academic press:
    Journal of Cancer (rok: 2018, tom: 9, strony: 4413-4421), Wydawca: IVYSPPING
    Status:
    Published
    DOI:
    10.7150/jca.27342 - link to the publication
  10. The significance of interferon gamma inducible protein 16 (IFI16) expression in drug resistant ovarian cancer cell lines
    Authors:
    Borucka Justyna, Sterzyńska Karolina, Kaźmierczak Dominika, Świerczewska Monika, Nowacka Marta, Wojtowicz Karolina, Klejewski Andrzej, Nowicki Michał, Zabel Maciej, Ramlau Rodryg, Januchowski Radosław
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2022, tom: 150, strony: E113036, 13 stron), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.3390/ijms23105846 - link to the publication
  11. The significance of microRNA genes expression in regulation of extracellular matrix and others drug resistant genes in drug resistant ovarian cancer cell lines
    Authors:
    Dominika Kaźmierczak, Karol Jopek, Karolina Sterzyńska, Barbara Ginter-Matuszewska, Michał Nowicki, Marcin Ruciński, Radosław Januchowski
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 9;21(7), strony: 2619), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21072619 - link to the publication
  12. New and Old Genes Associated with Primary and Established Responses to Cisplatin and Topotecan Treatment in Ovarian Cancer Cell Lines
    Authors:
    Monika Świerczewska, Andrzej Klejewski, Karolina Wojtowicz , Maciej Brązert , Dariusz Iżycki, Michał Nowicki , Maciej Zabel and Radosław Januchowski
    Academic press:
    Molecues (rok: 2017, tom: 22, strony: E1717 - 15 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22101717 - link to the publication

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