Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Combating drug-resistance in bacteria with organometallic antibiotics

2013/11/B/ST5/00997

Keywords:

antibacterial agents drug-resistance organometallic compounds antibiotics nucleobases

Descriptors:

  • ST5_23:
  • ST5_16:
  • NZ6_4: Bacteriology

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Łódzki, Wydział Chemii

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Konrad Kowalski 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 748 000 PLN

Project start date (Y-m-d): 2014-08-07

Project end date (Y-m-d): 2018-02-06

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Chromatograf cieczowy wraz z kolumnami chromatograficznymi i komputerem sterującym (320 000 PLN)
  2. waga laboratoryjna (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (12)
  1. Cymantrenyl-Nucleobases: Synthesis, Anticancer, Antitrypanosomal and Antimicrobial Activity Studies
    Authors:
    A. Jabłoński, K. Matczak, A. Koceva-Chyła, K. Durka, D. Steverding, K. Jakubiec-Krześniak, J. Solecka, D. Trzybiński, K. Woźniak, V. Andreu, G. Mendoza, M. Arruebo, K. Kochel, B. Krawczyk, D. Szczukocki, K. Kowalski
    Academic press:
    Molecules (rok: 2017, tom: 22, strony: 2220), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules22122220 - link to the publication
  2. Mechanisms of proton relay and product release by Class A b-lactamase at ultrahigh resolution
    Authors:
    E. M. Lewandowski, K. G. Lethbridge, R. Sanishvili, J. Skiba, K. Kowalski, Y. Chen
    Academic press:
    The Febs Journal (rok: 2018, tom: 285, strony: 87-100), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/febs.14315 - link to the publication
  3. Antibacterial Properties of Metallocenyl-7-ADCA Derivatives and Structure in Complex with CTX-M β-Lactamase
    Authors:
    E. M. Lewandowski, Ł. Szczupak, S. Wong, J. Skiba, A. Guśpiel, J Solecka,V. Vrček, K. Kowalski, Y. Chen
    Academic press:
    Organometallics (rok: 2017, tom: 36, strony: 1673-1676), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.organomet.6b00888 - link to the publication
  4. 1,1'-Bis(thymine)ferrocene Nucleoside:Synthesis and Study of Its Stereoselective Formation
    Authors:
    I. Anisimov, S. Saloman, A. Hildebrandt, H. Lang, D. Trzybiński, K. Woźniak, D. Sakic, V. Vrcek, K. Kowalski
    Academic press:
    ChemPlusChem (rok: 2017, tom: 82, strony: 859-866), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cplu.201700215 - link to the publication
  5. Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic
    Authors:
    E. M. Lewandowski, J. Skiba, N. J. Torelli, A. Rajnisz, J. Solecka, K. Kowalski, Y. Chen
    Academic press:
    Chemical Communications (rok: 2015, tom: 51, strony: 6186-6189), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C5CC00904A - link to the publication
  6. Cymantrene, Cyrhetrene and Ferrocene Nucleobase Conjugates: Synthesis, Structure, Computational Study, Electrochemistry and Antitrypanosomal Activity
    Authors:
    K. Kowalski, Ł. Szczupak, S. Saloman, D. Steverding, A. Jabłoński, V. Vrček, Dr. Alexander Hildebrandt, H. Lang, A. Rybarczyk-Pirek
    Academic press:
    ChemPlusChem (rok: 2017, tom: 2, strony: 303-314), Wydawca: Wiley VCH
    Status:
    Published
    DOI:
    10.1002/cplu.201600462 - link to the publication
  1. Metallocene beta-lactam antibiotics- preparation, antibacterial activity and mechanism of action"
    Authors:
    Ł. Szczupak, J. Skiba, A. Rajnisz, J. Solecka, E. M. Lewandowski, N. J. Torelli, Y. Chen, K. Kowalski
    Conference:
    XVIII International Symposium Advances in the Chemistry of Heteroorganic Compounds" (rok: 2015, ), Wydawca: Center of Molecular and Macromolecular Studies Polish Academy of Sciences
    Data:
    konferencja 20 listopada
    Status:
    Published
  2. Properties of novel cymantrene and cyrhetrene nucleobase conjugates
    Authors:
    A. Jabłoński, Ł. Szczupak, S. Saloman, A. Hildebrandt, H. Lang, D. Steverding, A. Rybarczyk-Pirek, V. Vrcek, K. Kowalski
    Conference:
    60 Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2017, ), Wydawca: PTChm
    Data:
    konferencja 17-21.09
    Status:
    Published
  3. Synthesis, Antibacterial Activity and Mechanism of Action of Ruthenocenyl Cephalosporins
    Authors:
    K. Kowalski, J. Solecka, Y. Chen, E. Lewandowski, J. Skiba, Ł. Szczupak
    Conference:
    XIX International Symposium "Advances in the Chemistry of Heteroorganic Compounds" (rok: 2016, ), Wydawca: Center of Molecular and Macromlecular Studies PAN and Section of Heteroorganic Chemistry Polish Chem. Soc.
    Data:
    konferencja 25 listopad
    Status:
    Published
  4. Ferroceneyl and ruthenocenyl beta-lactam antibiotics - antibacterial activity, DD-carboxypeptidase inhibition, and X-ray crystal structures with CTX-M beta-lactamase
    Authors:
    K. Kowalski, Ł. Szczupak, J. Solecka, A. Guspiel, J. Solecka, E. M. Lewandowski, N. J. Torelli, Y. Chen
    Conference:
    42nd International Conference on Coordination Chemistry (rok: 2016, ), Wydawca: University of Brest
    Data:
    konferencja 3-8 lipiec
    Status:
    Published
  5. Metallocene beta-lactam antibiotics: synthesis, and mechanism of antibacterial activity
    Authors:
    K. Kowalski, Y. Chen, J. Solecka, Ł. Szczupak, J. Skiba
    Conference:
    58 Zjazd Polskiego Towarzystwa Chemicznego w Gdańsku (rok: 2015, ), Wydawca: PTChm Gdańsk
    Data:
    konferencja 21-25 września
    Status:
    Published
  6. Metallocene derivatives of beta-lactam antibiotics: antibacterial activity and mechanism of action
    Authors:
    K.Kowalski, J. Skiba, Ł. Szczupak, A. Rajnisz, J. Solecka, E. M. Lewandowski, N. J. Torelli, Y. Chen
    Conference:
    13th Ferrocene Colloquium (rok: 2015, ), Wydawca: University of Leipzig, Germany
    Data:
    konferencja 22-24 luty
    Status:
    Published
  7. Metallocene beta-lactam antibiotics conjugates: synthesis, antibacterial activity and mechanism of action"
    Authors:
    K. Kowalski, E. M. Lewandowski, J. Skiba, Ł. Szczupak, A. Rajnisz, J. Solecka, N. J. Torelli, Y. Chen
    Conference:
    21th Conference on Organometallic Chemistry (EuCOMC XXI) (rok: 2015, ), Wydawca: European Association for Chemical and Molecular Sciences (EuCheMS)
    Data:
    konferencja 5-9 lipiec
    Status:
    Published
  8. Cymantrene and Cyrhetrene Nucleobase Conjugates with Activity Against Trypanosoma brucei
    Authors:
    A. Jabłoński, Ł. Szczupak, D. Steverding, S. Saloman, A. Hildebrandt, H. Lang, A. Rybarczyk-Pirek, V. Vrcek, K. Kowalski
    Conference:
    XIX International Symposium "Advances in the Chemistry of Heteroorganic Compounds" (rok: 2016, ), Wydawca: Center of Molecular and Macromlecular Studies PAN and Section of Heteroorganic Chemistry Polish Chem. Soc.
    Data:
    konferencja 25 listopad
    Status:
    Published
  9. Metallocene beta-lactam Antibiotics - Synthesis, Antibacterial Activity, and DD-Carboxypeptidase Inhibition
    Authors:
    K. Kowalski, Ł. Szczupak, J. Skiba, A. Guśpiel, J. Solecka, E. M. Lewandowski, N. J. Torelli, Y. Chen
    Conference:
    14th ferrocene Colloquium in Konstanz Germany (rok: 2016, ), Wydawca: University of Konstanz
    Data:
    konferencja 21-23,luty
    Status:
    Published
  10. Metallocenyl-7-ADCA derivatives: antibacterial properties and X-ray complex crystal structure with CTX-M beta-lactamase
    Authors:
    K.Kowalski, Y. Chen, E.M.Lewandowski, J. Skiba, J. Solecka
    Conference:
    15th Ferrocene Colloquium (rok: 2017, ), Wydawca: Uni Mainz
    Data:
    konferencja 19-21.02
    Status:
    Published
  11. Synthesis and Biological Activity of Metallocene-Modified Nucleobases
    Authors:
    K. Kowalski, J. Skiba, J. Anisimov, J. Solecka, I. Ott
    Conference:
    XXII International Roundtable on Nucleosides, nucleotides and Nucleic Acids (rok: 2016, ), Wydawca: International Society of Nucleosides, Nucleotides and Nucleic Acids
    Data:
    konferencja 18-22 llipiec
    Status:
    Published
  12. Combating bacterial resistance with organometallic beta-lactam antibiotics
    Authors:
    Ł. Szczupak, J. Skiba, A. Rajnisz, J. Solecka, E. M. Lewandowski, N. J. Torelli, Y. Chen, K. Kowalski
    Conference:
    X Ogólnopolskie Sympozjum Chemii Organicznej (OSCO X) (rok: 2015, ), Wydawca: Centrum Badań Molekularnych i Makromolekularnych PAN w Łodzi
    Data:
    konferencja 16-18 kwietnia
    Status:
    Published

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