Projects funded by the NCN

Unlocking longevity: galectins from the unique naked mole rat as a potential anti-aging agents for biomedical applicatio...

Call: PRELUDIUM 24 , Panel: NZ3

Principal investigator: Julia Wiktoria Ptak

Uniwersytet Wrocławski

Development of novel 1,3-selenazol-2-one derivatives incorporated into self-emulsifying drug delivery systems as a strat...

Call: OPUS 29 , Panel: NZ7

Principal investigator: dr hab. Robert Czarnomysy

Uniwersytet Medyczny w Białymstoku

Is ADP-ribosylation involved in the response to DNA double-strand breaks? An investigation employing the CRISPR-Cas9 sys...

Call: PRELUDIUM 24 , Panel: NZ3

Principal investigator: Weronika Justyna Pawluś

Uniwersytet Jagielloński

Targeting endothelial cell senescence in diabetic retinopathy with rapamycin-loaded nanoparticles

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Gabriela Burda

Uniwersytet Jagielloński

Tracing the aging phenotype at the cellular level

Call: OPUS 28 , Panel: NZ3

Principal investigator: dr hab. Adrianna Martyna Skoneczna

Instytut Biochemii i Biofizyki PAN

Role of stem cell- derived extracellular vesicles in regulation of autophagy and mitochondrial homeostasis in cardiac ce...

Call: OPUS 28 , Panel: NZ4

Principal investigator: prof. Ewa Katarzyna Zuba-Surma

Uniwersytet Jagielloński

Selective autophagy-mediated protein degradation as a potential therapeutic strategy for the treatment of inflammatory c...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Monika Emilia Marcinkowska

Uniwersytet Jagielloński

Autophagy in autoimmune vasculitis: a multiomics approach

Call: SONATA BIS 14 , Panel: NZ6

Principal investigator: dr hab. Marcin Piotr Surmiak

Uniwersytet Jagielloński

ERβ-mediated autophagy in colorectal cancer and its impact on carcinogenesis

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Julia Maria Lipowicz

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Mitochondrial quality control in plants: the relationship between mitophagy and the mitochondrial inner membrane proteas...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Małgorzata Heidorn-Czarna

Uniwersytet Wrocławski

Autophagy stimulation by genistein to cure Alzheimer disease: mechanisms and effects investigated using genetic (cellula...

Call: OPUS 27 , Panel: NZ2

Principal investigator: prof. Grzegorz Władysław Węgrzyn

Uniwersytet Gdański

Semaglutide and neurodevelopment: investigating risks arising from prenatal exposure to a widely popular drug for diabet...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Wnuk

Instytut Farmakologii PAN

Nuclear protein quality control in neurodegeneration

Call: SONATA 19 , Panel: NZ3

Principal investigator: dr Lidia Wróbel

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Jasmonates – underestimated signaling compounds that can significantly affect key stages of xylogenesis

Call: SONATA 19 , Panel: NZ9

Principal investigator: dr Natalia Wojciechowska

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Cuproptosis, a novel pathway of regulated cell death as a therapeutic target in treatment-naïve and targeted therapy-res...

Call: OPUS 25 , Panel: NZ5

Principal investigator: dr hab. Mariusz Łukasz Hartman

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Angelika Pietrzak-Wawrzyńska

Instytut Farmakologii PAN

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Barbara Przepiórska-Drońska

Instytut Farmakologii PAN

Bleomycin hydrolase, homocysteine metabolism, epigenetic regulation of mTOR signalling, autophagy, and Alzheimer's disea...

Call: OPUS 22 , Panel: NZ4

Principal investigator: dr hab. Joanna Perła-Kaján

Uniwersytet Przyrodniczy w Poznaniu, Wydział Rolnictwa, Ogrodnictwa i Biotechnologii

The role of impaired autophagy and peroxisome function in NAFLD development and their targeted recovery for improved eff...

Call: OPUS 22 (LAP) , Panel: NZ3

Principal investigator: prof. Mariusz Roman Więckowski

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Investigating the role of autophagy in oligodendrocytes in hypoxic-ischemic perinatalbrain injuries

Call: WEAVE-UNISONO , Panel: NZ4

Principal investigator: dr hab. Joanna Beata Sypecka

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Immunity signalling platforms on intracellular bacteria

Call: SONATA 17 , Panel: NZ3

Principal investigator: dr Michał Piotr Wandel

Instytut Biochemii i Biofizyki PAN

The role of NBR1 and the LSU (RESPONSE TO LOW SULFUR) proteins in stability of Arabidopsis thaliana catalases

Call: PRELUDIUM 20 , Panel: NZ3

Principal investigator: Anna Niemiro

Instytut Biochemii i Biofizyki PAN

Involvement of vacuolar processing enzyme (VPE) and lipase in the degradation of autophagic bodies in cells embryo axes ...

Call: PRELUDIUM 20 , Panel: NZ3

Principal investigator: Szymon Stefaniak

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

Investigation of a new therapeutic strategy to lower mutant protein in SCA3 / MJD

Call: OPUS 21 , Panel: NZ2

Principal investigator: prof. Maciej Figiel

Instytut Chemii Bioorganicznej PAN

Role of selective autophagy in activity control of ABA-responsive transcription factors in Arabidopsis

Call: OPUS 21 , Panel: NZ3

Principal investigator: prof. Agnieszka Ewa Sirko

Instytut Biochemii i Biofizyki PAN

Reversible senescence as a new mechanism of cancer cell resistance for chemotherapy. Analysis of the mechanism of cancer...

Call: SONATINA 5 , Panel: NZ3

Principal investigator: dr Karolina Anna Staniak

Politechnika Warszawska, Wydział Chemiczny

The importance of selective autophagy and autolysis in the process of phloemogenesis: Identification and characteristics...

Call: OPUS 20 , Panel: NZ3

Principal investigator: dr hab. Agnieszka Maria Bagniewska-Zadworna

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

In search of adaptive strategies in obligatory predators - The immunological mechanisms in reared model spider species S...

Call: OPUS 19 , Panel: NZ8

Principal investigator: dr hab. Grażyna Iwona Wilczek

UNIWERSYTET ŚLĄSKI, Wydział Nauk Przyrodniczych

Molecular mechanisms of genistein-mediated autophagy stimulation, and its cellular and physiological effects in Huntingt...

Call: OPUS 19 , Panel: NZ2

Principal investigator: prof. Grzegorz Władysław Węgrzyn

Uniwersytet Gdański, Wydział Biologii

Trehalose releasing nanogels for autophagy stimulation

Call: PRELUDIUM BIS 1 , Panel: ST5

Principal investigator: dr hab. Ilona Wioletta Wandzik

Politechnika Śląska, Wydział Chemiczny

Role of autophagy in experimental autoimmune myocarditis

Call: OPUS 18 , Panel: NZ5

Principal investigator: dr hab. Przemysław Jerzy Błyszczuk

Uniwersytet Jagielloński, Collegium Medicum

Mechanism of regulation glycosaminoglycan levels by resveratrol in a mouse model of a neuronopathic disease from the muc...

Call: PRELUDIUM 18 , Panel: NZ2

Principal investigator: Estera Elmira Rintz

Uniwersytet Gdański, Wydział Biologii

In search of spectroscopic markers of autophagy based on pharmacologically induced phospholipidosis in endothelial cells

Call: PRELUDIUM 18 , Panel: ST4

Principal investigator: Ewelina Joanna Bik

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Unveiling the molecular mechanism of microautophagy in plants

Call: SONATA 15 , Panel: NZ3

Principal investigator: dr Shino Yamada

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Cellular adaptation to cold.

Call: GRIEG 1 , Panel: NZ3

Principal investigator: dr Wojciech Mieczysław Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Molecular insight into the mechanism of peroxisome degradation via autophagy in land plants

Call: SONATA BIS 9 , Panel: NZ3

Principal investigator: dr Shino Yamada

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

How to keep lipids in the leves? Deciphering the interplay between lipid storage and degradation during leaf senescence.

Call: SONATA BIS 9 , Panel: NZ1

Principal investigator: dr hab. Agnieszka Zienkiewicz

Uniwersytet Mikołaja Kopernika, Interdyscyplinarne Centrum Nowoczesnych Technologii

Reactive oxygen species and autophagy in Staphylococcus aureus infection – double-edged swords?

Call: SONATA BIS 9 , Panel: NZ6

Principal investigator: dr Tomasz Krzysztof Prajsnar

Uniwersytet Jagielloński

The role of autophagy in the regulation of secretion of extracellular vesicles and proteins at different stages of vascu...

Call: OPUS 16 , Panel: NZ3

Principal investigator: dr hab. Grażyna Krystyna Mosieniak

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Impact of Polycomb Complex PRC1 inhibition on autophagy process in endometrial and breast cancer cells

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Aleksandra Ewa Szustka

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Effect of different dietary fatty acids on autophagy induction and metabolic activity in hypertrophic adipocytes

Call: OPUS 16 , Panel: NZ9

Principal investigator: dr hab. Małgorzata Katarzyna Gajewska

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

Investigation of the mechanism and the role of Interferon-Lambda2-induced autophagy on breast and pancreatic adenocarcin...

Call: PRELUDIUM 16 , Panel: NZ5

Principal investigator: Rafał Paweł Pingwara

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Medycyny Weterynaryjnej

Stimulation of various autophagy induction pathways in the light of efficiency of glycosaminoglycan degradation in neuro...

Call: PRELUDIUM 15 , Panel: NZ2

Principal investigator: Lidia Łucja Gaffke

Uniwersytet Gdański, Wydział Biologii

The effect of swim training on autophagy flux and oxidative stress in spinal cord of mice with Amyotrophic Lateral Scler...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Katarzyna Patrycja Dzik

Uniwersytet Gdański

Regulation of autophagy by paternal and maternal genome during Embryonic Diapause

Call: PRELUDIUM 15 , Panel: NZ3

Principal investigator: Roberta Arena

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Inhibition of tyrosine phosphatase as a strategy to enhance insulin sensitivity through activation of chaperone mediated...

Call: OPUS 15 , Panel: NZ7

Principal investigator: dr hab. Krzysztof Marycz

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Biologii i Hodowli Zwierząt

The role of autophagy in the regulation of circadian clock of Drosophila melanogaster

Call: OPUS 14 , Panel: NZ3

Principal investigator: dr Milena Anna Damulewicz

Uniwersytet Jagielloński, Wydział Biologii

The role of estrogens in the regulation of PRODH/POX-dependent apoptosis/autophagy in breast cancer cells (MCF-7)

Call: PRELUDIUM 14 , Panel: NZ7

Principal investigator: dr Ilona Ościłowska

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Role of autophagy and mitochondrial quality control mechanisms in the protective action of PGC-1alpha against oxidative ...

Call: OPUS 14 , Panel: NZ3

Principal investigator: prof. Janusz Błasiak

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Significance of FGFR2 in regulation of autophagy in breast carcinoma - implications for disease prognostication

Call: OPUS 14 , Panel: NZ3

Principal investigator: dr hab. Rafał Sebastian Sądej

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego