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Reactive oxygen species and autophagy in Staphylococcus aureus infection – double-edged swords?

2019/34/E/NZ6/00137

Keywords

Descriptors

  • NZ6_001: Odporność swoista i nieswoista
  • NZ6_004: Bakteriologia
  • NZ3_001: Biologia komórki

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Jagielloński

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Tomasz Krzysztof Prajsnar

Number of co-investigators in the project: 3

Call

SONATA BIS 9 – announced on 2019-06-17

Amount awarded
3 453 281 PLN
Project start date
2020-04-17
Project end date
2027-04-16
Project duration
84 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (6)

  1. A subset of neutrophil phagosomes is characterised by pulses of Class I PI3K activity

    Authors:
    Clare F Muir, Constantino Carlos Reyes-Aldasoro, Tomasz K Prajsnar, Bartosz J Michno, Justyna Cholewa-Waclaw, Yin X Ho, Audrey Bernut, Catherine A Loynes, Stone Elworthy, Kieran A Bowden, Ashley J Cadby, Lynne R Prince, Jason S King, Felix Ellett, Alison M Condliffe, Stephen A Renshaw
    Academic press:
    Disease Models & Mechanisms (year: 2025, volume: 18 (9), pages: dmm052042), Publisher: The Company of Biologists
    Status:
    Published
    DOI:
    10.1242/dmm.052042 – link to the publication

  2. Pneumolysin-dependent and independent non-canonical autophagy processes mediate host defense against pneumococcal infection

    Authors:
    Bartosz J. Michno, Niedharsan Pooranachandran, Tonisha C. Smith, Erin Faught, Sandra Lipowská, Andrew K. Fenton, Annemarie H. Meijer, and Tomasz K. Prajsnar
    Academic press:
    Autophagy (year: 2025, volume: 21(12), pages: 3077 - 3096), Publisher: Taylor and Francis Ltd.
    Status:
    Published
    DOI:
    10.1080/15548627.2025.2559728 – link to the publication

  3. Enterococcal cell wall remodelling underpins pathogenesis via the release of the Enteroccocal Polysaccharide Antigen (EPA)

    Authors:
    Robert E. Smith, Bartosz J. Michno, Rene L. Christena, Finn O'Dea, Jessica L. Davis, Ian D.E.A. Lidbury, Marcel G. Alamán-Zárate, Danai Stefanidi, Emmanuel Maes, Hannah Fisher, Tomasz K. Prajsnar, Stéphane Mesnage
    Academic press:
    PLoS Pathogens (year: 2025, volume: 21(6), pages: e1012771), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1012771 – link to the publication

  4. Gingipains protect Porphyromonas gingivalis from macrophage-mediated phagocytic clearance

    Authors:
    Magdalena Widziolek, Anna Mieszkowska, Magdalena Marcinkowska, Bartlomiej Salamaga, Justyna Folkert, Krzysztof Rakus, Magdalena Chadzinska, Jan Potempa, Graham P. Stafford, Tomasz K. Prajsnar, Craig Murdoch
    Academic press:
    PLoS Pathogens (year: 2025, volume: 21(1), pages: e1012821), Publisher: Public Library of Science (PLOS)
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1012821 – link to the publication

  5. Phagosomal acidification is required to kill Streptococcus pneumoniae in a zebrafish model

    Authors:
    Tomasz K. Prajsnar, Bartosz J. Michno, Niedharsan Pooranachandran, Andrew K. Fenton, Tim J. Mitchell, David H. Dockrell, Stephen A. Renshaw
    Academic press:
    Cellular Microbiology (year: 2022, volume: Volume 2022, pages: Article ID 9429516), Publisher: Wiley - Hindawi
    Status:
    Published
    DOI:
    10.1155/2022/9429516 – link to the publication

  6. Tilapia Lake Virus-Induced Neuroinflammation in Zebrafish: Microglia Activation and Sickness Behavior

    Authors:
    Miriam Mojzesz, Magdalena Widziolek, Mikolaj Adamek, Urszula Orzechowska, Piotr Podlasz, Tomasz K Prajsnar, Niedharsan Pooranachandran, Anna Pecio, Anna Michalik, Win Surachetpong, Magdalena Chadzinska, Krzysztof Rakus
    Academic press:
    Frontiers in Immunology (year: 2021, volume: Volume 12, pages: Article 760882), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2021.760882 – link to the publication

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