Projects funded by the NCN

Characterization of nucleic acids as the allosteric activators of PAD4

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński

Correlated mean-field interactions propagated along polypeptide chain as a key to understanding the structure formation,...

Call: OPUS 26 , Panel: ST4

Principal investigator: prof. Józef Adam Liwo

Uniwersytet Gdański, Wydział Chemii

Light-induced photoreceptor morphological changes – Towards objective and impartial diagnostics in ophthalmology

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Humberto Couto Fernandes

Instytut Chemii Fizycznej Polskiej Akademii Nauk, Międzynarodowe Centrum Badań Oka

Allosteric regulation of cathepsins and procathepsins enzymatic activity by glycosaminoglycans and their mimetics

Call: SONATINA 7 , Panel: ST4

Principal investigator: dr Krzysztof Kamil Bojarski

Politechnika Gdańska, Wydział Chemiczny

Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński, Collegium Medicum

Stop the biting: tracking the insecticide-mediated allosteric changes in voltage-gated sodium channels and design of sel...

Call: PRELUDIUM 20 , Panel: NZ3

Principal investigator: dr Beata Niklas

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

Call: OPUS 19 , Panel: ST4

Principal investigator: prof. Wiktor Adam Koźmiński

Uniwersytet Warszawski, Wydział Chemii

Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

Call: SONATA BIS 8 , Panel: NZ7

Principal investigator: dr Monika Emilia Marcinkowska

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum

Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.

Call: PRELUDIUM 15 , Panel: NZ1

Principal investigator: Michał Adam Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Molecular mechanisms of the allosteric communication in thymidylate synthase

Call: PRELUDIUM 14 , Panel: NZ1

Principal investigator: dr Jan Marcin Ludwiczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Jakub Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Allosteric photoregulation in macrocyclic hosts

Call: OPUS 12 , Panel: ST5

Principal investigator: dr Volodymyr Sashuk

Instytut Chemii Fizycznej Polskiej Akademii Nauk

The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Nikiforuk

Instytut Farmakologii PAN

Computational investigation of the dynamic and physico-chemical properties of pteridine reductase 1 of human trypanosoma...

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Joanna Aspazja Panecka-Hofman

Uniwersytet Warszawski, Wydział Fizyki

Interdomain allosteric communication in Rad50 protein and its role in genome maintence by Mre11 complex

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Artur Krężel

Uniwersytet Wrocławski, Wydział Biotechnologii

Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

The effects of ligands of the alpha7 nicotinic acetylcholine receptors on complex cognitive processes and social behavio...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Agnieszka Teresa Potasiewicz

Instytut Farmakologii PAN

Hydration effects in protein kinases

Call: SONATA 6 , Panel: ST4

Principal investigator: dr Piotr Mikołaj Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Katarzyna Małgorzata Targowska-Duda

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

The effects of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors on complex cognitive processes...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Nikiforuk

Instytut Farmakologii PAN

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Probing the selectivity of zinc allosteric modulation in various serotonin receptor subtypes

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: Grzegorz Marek Satała

Instytut Farmakologii PAN

Toward understanding allosteric regulation of the proteasome activity

Call: OPUS 1 , Panel: ST5

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii