Projects funded by the NCN

Allosteric regulation of cathepsins and procathepsins enzymatic activity by glycosaminoglycans and their mimetics

Call: SONATINA 7 , Panel: ST4

Principal investigator: dr Krzysztof Bojarski

Politechnika Gdańska, Wydział Chemiczny

Self-learning systems in the design of compounds modulating GPCR receptors activation.

Call: OPUS 20 , Panel: NZ2

Principal investigator: dr hab. Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

The effects of ligands of the alpha7 nicotinic acetylcholine receptors on complex cognitive processes and social behavio...

Call: PRELUDIUM 8 , Panel: NZ7

Principal investigator: Agnieszka Potasiewicz

Instytut Farmakologii PAN

Hydrografically originated allometric relations in selected lake-catchment systems of the Polesie Region

Call: SONATA 9 , Panel: ST10

Principal investigator: dr Beata Ferencz

Uniwersytet Przyrodniczy w Lublinie, Wydział Biologii i Hodowli Zwierząt

Using X-ray crystallography for localization of the sites of binding of allosteric inhibitors and activators within the ...

Call: PRELUDIUM 9 , Panel: NZ1

Principal investigator: Julia Witkowska

Uniwersytet Gdański, Wydział Chemii

Light-induced photoreceptor morphological changes – Towards objective and impartial diagnostics in ophthalmology

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Humberto Couto Fernandes

Instytut Chemii Fizycznej Polskiej Akademii Nauk, Międzynarodowe Centrum Badań Oka

Allosteric photoregulation in macrocyclic hosts

Call: OPUS 12 , Panel: ST5

Principal investigator: dr Volodymyr Sashuk

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Probing the selectivity of zinc allosteric modulation in various serotonin receptor subtypes

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: Grzegorz Satała

Instytut Farmakologii PAN

Structural studies based on low sequence similarity of G protein-coupled receptors activated by hormones and allosteric ...

Call: SONATA 4 , Panel: NZ1

Principal investigator: dr Dorota Latek

Uniwersytet Warszawski, Wydział Chemii

Computational investigation of the dynamic and physico-chemical properties of pteridine reductase 1 of human trypanosoma...

Call: SONATA 11 , Panel: NZ1

Principal investigator: dr Joanna Panecka-Hofman

Uniwersytet Warszawski, Wydział Fizyki

Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Characterization of nucleic acids as the allosteric activators of PAD4

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński w Krakowie

Analysis of the structural and functional mechanisms of action of the nicotinic receptors modulators.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Katarzyna Targowska-Duda

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Investigation of the molecular mechanisms of anti-leukemic activity of SK053, a small molecule compound targeting enzyme...

Call: SONATA BIS 3 , Panel: NZ5

Principal investigator: prof. Dominika Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Exploring the allosteric regulation of the SARS CoV-2 hydrolases using methyl-TROSY NMR spectroscopy - in search of nove...

Call: OPUS 19 , Panel: ST4

Principal investigator: prof. Wiktor Adam Koźmiński

Uniwersytet Warszawski, Wydział Chemii

Toward understanding allosteric regulation of the proteasome activity

Call: OPUS 1 , Panel: ST5

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii

Sexual traits morphological variability and allometry analysis in Anostraca (Crustacea: Branchiopoda) - case of Branchip...

Call: PRELUDIUM 1 , Panel: NZ8

Principal investigator: Michał Czyż

Uniwersytet im. Adama Mickiewicza, Wydział Biologii

The effects of positive allosteric modulators of alpha7 nicotinic acetylcholine receptors on complex cognitive processes...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Nikiforuk

Instytut Farmakologii PAN

Stop the biting: tracking the insecticide-mediated allosteric changes in voltage-gated sodium channels and design of sel...

Call: PRELUDIUM 20 , Panel: NZ3

Principal investigator: dr Beata Niklas

Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Nauk Biologicznych i Weterynaryjnych

New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Krzysztof Tomasz Kamiński

Uniwersytet Jagielloński, Collegium Medicum

The evaluation of the efficacy of alpha7 nicotinic acetylcholine receptor ligands in rat models of autism

Call: OPUS 12 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Nikiforuk

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Allosteric inhibitors of proteasome - optimization of the structure of PR39 analogs in order to achieve greater efficien...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Małgorzata Giżyńska

Uniwersytet Gdański, Wydział Chemii

Molecular mechanisms of the allosteric communication in thymidylate synthase

Call: PRELUDIUM 14 , Panel: NZ1

Principal investigator: dr Jan Ludwiczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Molecular Mechanisms of GABAA Receptor Allosteric Modulation by pH Level.

Call: PRELUDIUM 15 , Panel: NZ1

Principal investigator: Michał Michałowski

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

Variation in sapling architecture of shade-tolerant tree species in light, habitat and altitudinal gradients in relation...

Call: SONATA 11 , Panel: NZ8

Principal investigator: dr Olga Orman

Uniwersytet Rolniczy im. Hugona Kołłątaja w Krakowie, Wydział Leśny

Effects of rapid weight gain on tylosin and enrofloxacin pharmacokinetics in turkeys - dosage modelling and validation b...

Call: SONATA 11 , Panel: NZ7

Principal investigator: dr Błażej Poźniak

Uniwersytet Przyrodniczy we Wrocławiu, Wydział Medycyny Weterynaryjnej

Hydration effects in protein kinases

Call: SONATA 6 , Panel: ST4

Principal investigator: dr Piotr Setny

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Correlated mean-field interactions propagated along polypeptide chain as a key to understanding the structure formation,...

Call: OPUS 26 , Panel: ST4

Principal investigator: prof. Józef Liwo

Uniwersytet Gdański, Wydział Chemii

Interdomain allosteric communication in Rad50 protein and its role in genome maintence by Mre11 complex

Call: OPUS 11 , Panel: NZ1

Principal investigator: prof. Artur Krężel

Uniwersytet Wrocławski, Wydział Biotechnologii

Molecular modeling of allosteric binding and allosteric-orthosteric coupling in cannabinoid receptor CB1

Call: PRELUDIUM 12 , Panel: NZ1

Principal investigator: Jakub Jakowiecki

Uniwersytet Warszawski, Wydział Chemii

Postembrionic development of the tracheal system of holometabolous insects in context of aptery.

Call: PRELUDIUM 12 , Panel: NZ8

Principal investigator: Marcin Raś

Muzeum i Instytut Zoologii Polskiej Akademii Nauk

Evaluation of therapeutic role of novel positive allosteric modulators of GABA-A receptor in ischemic brain stroke

Call: SONATA BIS 8 , Panel: NZ7

Principal investigator: dr Monika Marcinkowska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny