Projects funded by the NCN

Effect of deimination of essential arginine residues on the function of protease inhibitors and other components of inna...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Tomasz Kantyka

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Impact of combined therapy of non-steroidal anti-inflammatory drugs and selective serotonin reuptake inhibitors on oxida...

Call: OPUS 3 , Panel: NZ5

Principal investigator: dr hab. Piotr Gałecki

Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski; Klinika Psychiatrii Dorosłych

Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

Call: PRELUDIUM 3 , Panel: NZ7

Principal investigator: dr Mirosława Anna Skupińska

Instytut Chemii Bioorganicznej PAN

Stimulation of endogenous neurogenesis as a novel therapeutic strategy in neonatal hypoxic-ischemic brain injury.

Call: OPUS 3 , Panel: NZ3

Principal investigator: dr Małgorzata Nałęcz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The role of corticotropin releasing factor (CRF) in low and high anxiety rats, and teh iteraction between of the CRF sys...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr Anna Karolina Skórzewska

Instytut Psychiatrii i Neurologii

Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Ewelina Marta Węglarz-Tomczak

Politechnika Wrocławska, Wydział Chemiczny

Evaluation of pharmacological activity of new, nonselective gamma-aminobutyric acid (GABA) transport inhibitors in some ...

Call: OPUS 3 , Panel: NZ7

Principal investigator: dr hab. Kinga Sałat

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

Call: OPUS 3 , Panel: ST5

Principal investigator: dr hab. Damian Plażuk

Uniwersytet Łódzki, Wydział Chemii

Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Karolina Ewa Piecyk

Uniwersytet Warszawski, Wydział Chemii

The influence of metabolic pathway inhibitors on the development and quality of bovine embryos produced in vitro.

Call: OPUS 3 , Panel: NZ9

Principal investigator: dr hab. Dorota Marta Cieślak

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

Pattern-Specific Inhibitors (PSI) - introduction and basic characteristics of a new class of inhibitors that block recog...

Call: OPUS 3 , Panel: NZ6

Principal investigator: dr Krzysztof Guzik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Research into the understanding of a defense mechanism of wheat (Triticum aestivum) in response to feeding Oulema spp. -...

Call: OPUS 2 , Panel: NZ9

Principal investigator: dr hab. Aleksandra Julia Obrępalska-Stęplowska

Instytut Ochrony Roślin - Państwowy Instytut Badawczy

Solution NMR investigations of human cystatin C - structure, dynamics and protein-ligand interactions.

Call: PRELUDIUM 2 , Panel: ST4

Principal investigator: Martyna Ewa Maszota-Zieleniak

Uniwersytet Gdański, Wydział Chemii

Hydrogen exchange mass spectrometry (HXMS) for studying human serum amyloid A fibril formation.

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: Marta Sosnowska

Uniwersytet Gdański, Wydział Chemii

Novel urease inhibitors as means to control ureolytic microbial pathogens

Call: OPUS 2 , Panel: NZ6

Principal investigator: dr Agnieszka Grabowiecka

Politechnika Wrocławska

Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Sebastian Demkowicz

Politechnika Gdańska

Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

Call: OPUS 2 , Panel: ST5

Principal investigator: dr hab. Piotr Przybylski

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

Call: OPUS 2 , Panel: ST5

Principal investigator: dr Anna Zawadzka

Uniwersytet Warszawski, Wydział Chemii

Function of DNA methylation and CNV-type polymorphisms of genes encoding metalloproteinase and their tissue inhibitors i...

Call: OPUS 2 , Panel: NZ5

Principal investigator: dr Edyta Magdalena Majorczyk

Politechnika Opolska, Wydział Wychowania Fizycznego i Fizjoterapii

The study of adsorption mechanisms of N-benzenamino(boronphenyl)methylphosphonic acids on different metal surfaces

Call: PRELUDIUM 2 , Panel: ST4

Principal investigator: dr Natalia Anna Piergies

Uniwersytet Jagielloński, Wydział Chemii

Comparison of the mechanism of action of valproic acid and levetiracetam as histone deacetylase inhibitors in ovarian ca...

Call: PRELUDIUM 2 , Panel: NZ7

Principal investigator: Patrycja Katarzyna Kwiecińska

Uniwersytet Jagielloński, Wydział Biologii i Nauk o Ziemi

Epigenetic regulation of expression of genes involved in extracellular matrix remodeling and angiogenesis during develop...

Call: PRELUDIUM 2 , Panel: NZ5

Principal investigator: dr Radosław Bernard Maksym

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

Inhibitors of serine proteases as regulators of dendritic cell function.

Call: MAESTRO 1 , Panel: NZ5

Principal investigator: prof. Joanna Cichy

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Crystallography of DNA repair enzymes as a tool to study substrate specifity and a mechanism of inhibition

Call: HARMONIA 1 , Panel: NZ1

Principal investigator: prof. Barbara Alicja Tudek

Instytut Biochemii i Biofizyki PAN

The role of inflammatory and anti-inflammatory cytokines in the process of epileptogenesis and their interaction with in...

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr Piotr Maciejak

Instytut Psychiatrii i Neurologii

Significance of the TNF, TNFR1, TNFR2, TRAF1, TRAF6 and TACE gene polymorphisms, clinical parameters and biomarkers for ...

Call: OPUS 1 , Panel: NZ5

Principal investigator: dr hab. Jerzy Piotr Świerkot

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Farmaceutyczny z Oddziałem Analiutyki Medycznej, Wydział Lekarski

Metalloproteinases and tissue inhibitors of metalloproteinases expression in serum and leukocytes in children with prima...

Call: OPUS 1 , Panel: NZ6

Principal investigator: dr Joanna Beata Trojanek

INSTYTUT - POMNIK - CENTRUM ZDROWIA DZIECKA

3D structure-based search for selective inhibitor of thymidylate synthase of nematodes, a potential drug in chemotherapy...

Call: OPUS 1 , Panel: NZ6

Principal investigator: prof. Wojciech Krzysztof Rode

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Inhibitors, protein aggregation and carbon nanotube

Call: OPUS 1 , Panel: NZ1

Principal investigator: dr hab. Mai Suan Li

Instytut Fizyki PAN

Derivation of genuine rabbit embryonic stem cells

Call: PRELUDIUM 1 , Panel: NZ3

Principal investigator: Andrea Catalina Konarska Diaz

Instytut Genetyki i Hodowli Zwierząt PAN

Phenolic compounds as pancreatic lipase inhibitors

Call: OPUS 1 , Panel: NZ9

Principal investigator: dr Anna Danuta Podsędek

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

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Call: SONATA 1 , Panel: NZ9

Principal investigator: dr Mariola Aleksandra Dietrich

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Discovery and development of small-molecule inhibitors of USP2 for targeted, non-genotoxic therapy of cancer

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Tadeusz Andrzej Holak

Uniwersytet Jagielloński, Wydział Chemii

Identification of cytochrome P450 isoenzymes involved in the metabolism of levomepromazine in the human

Call: OPUS 1 , Panel: NZ4

Principal investigator: dr hab. Jacek Wójcikowski

Instytut Farmakologii PAN

Study of casein kinase CK2 inhibition mechanisms

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Maria Wanda Bretner

Politechnika Warszawska, Wydział Chemiczny

Chemical syntesis and evaluation of biochemical properties of 7-methyloguanosine 5'-diphosphate analogs as inhibitors of...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Marcin Jarosław Ziemniak

Uniwersytet Warszawski, Wydział Fizyki

PAI-1 as a regulator of pro- and anti - apoptotic balance in endothelial cells

Call: OPUS 1 , Panel: NZ3

Principal investigator: dr hab. Joanna Boncela

Instytut Biologii Medycznej PAN

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Józef Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

The search for novel human proteasome inhibitors and fluorogenic substrates.

Call: SONATA 1 , Panel: ST5

Principal investigator: dr Dawid Dębowski

Uniwersytet Gdański, Wydział Chemii

RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

Call: SONATA 1 , Panel: NZ1

Principal investigator: dr Katarzyna Pachulska-Wieczorek

Instytut Chemii Bioorganicznej PAN

Determination of the structural elements responsible for the narrow substrate specificity of staphylococcal proteases Sp...

Call: PRELUDIUM 1 , Panel: NZ1

Principal investigator: Michał Waldemar Zdżalik

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Synthesis and studies of reaction products of oxirane derivatives with the -NH-(C=)-Br functionality of heteroaromatic c...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: dr Marzena Agnieszka Baran

Uniwersytet Jagielloński- Collegium Medicum, Wydział Farmaceutyczny z Oddziałem Analityki Medycznej

Stilbene and stilbazole derivatives as potential cyclooxygenase-2 (COX-2) inhibitors with probable antitumor and chemopr...

Call: PRELUDIUM 1 , Panel: NZ4

Principal investigator: Miłosz Jakub Regulski

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Can extracts from Epilobium sp. inhibit proliferation of prostate cell LNCaP by influencing the activity of histone acet...

Call: SONATA 1 , Panel: NZ4

Principal investigator: dr hab. Anna Karolina Kiss

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny

The expression of complement inhibitors in ovarian and corpus uteri cancers - a new perspective for immunotherapy

Call: SONATA 1 , Panel: NZ7

Principal investigator: dr hab. Lucyna Kapka-Skrzypczak

Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie, Wydział Turystyki i Nauk o Zdrowiu