Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

2011/01/B/ST5/03772

Keywords:

peptide splicing trypsin inhibitor SFTI-1 double-sequence analogues serine proteinases peptide synthesis

Descriptors:

  • ST5_16:
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Rolka 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 425 400 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2014-11-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Mikroskop fluorescencyjny HBO 100, Carl Ceiss (142 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Investigation of peptide splicing using two-peptide-chain analogs of trypsin inhibitor SFTI-1
    Authors:
    Karna N., Dębowski D., Gitlin A., Łęgowska A., Rolka K.
    Academic press:
    FEBS J. (rok: 2013, tom: 280, strony: 6213-6222), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1111/febs.12542 - link to the publication
  2. Peptide splicing in a double-sequence analogue of trypsin inhibitor SFTI-1 substituted in the P1 positions by peptoid monomers
    Authors:
    Karna N., Dębowski D., Łęgowska A., Bąchor R., Szewczuk Z., Rolka K.
    Academic press:
    Biopolymers (rok: 2015, tom: 104, strony: 206-2012), Wydawca: Wiley Periodicals, Inc
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Conformational studies of [Nphe5]SFTI-1 by means of 2D NMR spectroscopy in conjunction with molecular dynamics calculations
    Authors:
    Brzozowski K., Stawikowski M., Slusarz R., Sikorska E., Lesner A., Łęgowska A., Rolka K.
    Academic press:
    J.Mol. Struct. (rok: 2015, tom: 1100, strony: 203-207), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  4. Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds - synthesis and applications
    Authors:
    Lesner A., Karna N., Łęgowska A., Wysocka M., Guzow K., Sieradzan A., Sieńczyk M., Trzonkowski P., Pikuła P., Zieliński M., Kosikowska P., Łęgowska Ł, Dębowski D., Wiczk W., Rolka K.
    Academic press:
    Biopolymers (rok: 2014, tom: 102, strony: 124-135), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/bio.22442 - link to the publication
  5. Investigation of protease catalyzed peptide splicing in analogues of sunflower trypsin inhibitor 1 (SFTI-1)
    Authors:
    Karna N., Malicki S., Dębowski D., Golik P., Gitlin A., Grudnik P., Łęgowska A., Wladyka B., Brzozowski K., Dubin G., Rolka K.
    Academic press:
    ChemBioChem (rok: 2015, ), Wydawca: Wiley Periodicals, Inc
    Status:
    Accepted for publication
    DOI:
    10.1002/cbi.2015000296 - link to the publication
  6. Atomic resolution crystal structure ofHV-BBI protease inhibitor from amphibian skin in complex with bovine trypsin
    Authors:
    Grudnik P., Debowski D., Łegowska A., Malicki S., Golik P., Karna N., Rolka K., Dubin D.
    Academic press:
    Proteins (rok: 2014, tom: -, strony: -), Wydawca: Wiley Periodicals, Inc.
    Status:
    Published
    DOI:
    10.1002/prot.24750 - link to the publication
  1. Fluorescent analogues of SFTI-1 – synthesis and application
    Authors:
    Łęgowska A., Wysocka M., Lesner A., Filipowicz M., Sieradzan A., Pikuła M., Trzonkowski P.
    Conference:
    32nd European Peptide Symposium (rok: 2012, ), Wydawca: European Peptide Society
    Data:
    konferencja 2 - 7 września
    Status:
    Published
  2. The analogues of SFTI-1 modified in the P1 position by, β- and γ-amino acids and N-substituted β-alanines
    Authors:
    Łęgowska A., Łukajtis R., Filipowicz M., Łęgowska M., Dębowski D., Wysocka M., Lesner A., Rolka K.
    Conference:
    32nd European Peptide Symposium (rok: 2012, ), Wydawca: European Peptide Society
    Data:
    konferencja 2 - 7 września
    Status:
    Published
  1. Peptidic plant origin inhibitors of serine proteinases
    Authors:
    K. Rolka, A. Lesner, A. Łęgowska, M. Wysocka
    Book:
    Antitumor Potential and Other Emerging Medicinal Properties of Natural Compounds (rok: 2013, tom: Brak, strony: 187 – 204), Wydawca: Springer, ISBN: 978-94-007-6214-5 (eBook); ISNB 978-94-007-6213-8
    Status:
    Published

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