Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Epigenetic regulation of expression of genes involved in extracellular matrix remodeling and angiogenesis during development of endometriosis.

2011/03/N/NZ5/05899

Keywords:

endometriosis angiogenesis extracellular matrix remodeling inhibitors of metalloproteinases TIMP RECK epigenetics CpG islands methylation massively parallel sequencing

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ3_1: Cell biology

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Radosław Maksym 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 247 500 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2016-08-01

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (4)
  • Book publications / chapters in book publications (3)
  1. The bimodal role of matrix metalloproteinases and their inhibitors in etiology and pathogenesis of endometriosis
    Authors:
    Bałkowiec M., Maksym R., Włodarski P.
    Academic press:
    Molecular Medicine Reports (rok: 2018, tom: 18, strony: 3123-3136), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2018.9303 - link to the publication
  2. Deep infiltrating endometriosis as a cause of severe urogynecological complications despite invasive treatment – report of two cases from the center of endometriosis surgery
    Authors:
    D. Filipecka-Tyczka, A. Kajdy, B.P. Siekierski, M. Stańczyk, A. Rogowski, M. Rabijewski, R.B. Maksym
    Academic press:
    Clinical and Experimental Obstetrics and Gynecology (rok: 2020, tom: 47, strony: 955-960), Wydawca: IMR Press
    Status:
    Published
    DOI:
    10.31083/j.ceog.2020.06.2092 - link to the publication
  3. Implementation of ethiodized oil for treatment of endometriosis-associated infertility
    Authors:
    Radosław Maksym
    Academic press:
    Kwartalnik Naukowy Fides et Ratio (rok: 2021, tom: 47, strony: 84-94), Wydawca: Fides et Ratio
    Status:
    Published
    DOI:
    10.34766/fetr.v47i3.897 - link to the publication
  4. ONCOFERTILITY – FERTILITY PRESERVATION IN ONCOLOGY.
    Authors:
    R. Maksym
    Academic press:
    Życie i Płodność (rok: 2017, tom: 1, strony: 147-164), Wydawca: Wydawnictwo SWPR
    Status:
    Published
    DOI:
    ISSN:1898-2150 - link to the publication
  5. Post-finasteride syndrome – does it really exist?
    Authors:
    Radosław Maksym, Anna Kajdy, Michał Rabijewski
    Academic press:
    The Aging Male (rok: 2019, tom: 22, strony: 250-259), Wydawca: Taylor anf Francis
    Status:
    Published
    DOI:
    10.1080/13685538.2018.1548589 - link to the publication
  6. Epithelial Cells of Deep Infiltrating Endometriosis Harbor Mutations in Cancer Driver Genes
    Authors:
    Koppolu, A.; Maksym, R.B.; Paskal, W.; Machnicki, M.; Rak, B.; Pępek, M.; Garbicz, F.; Pełka, K.; Kuśmierczyk, Z.; Jacko, J.; Rydzanicz, M.; Banach-Orłowska, M.; Stokłosa, T.; Płoski, R.; Malejczyk, J.; Włodarski, P.K.
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10040749 - link to the publication
  7. Methylation profile of inhibitors of metalloproteinases in endometriosis
    Authors:
    Magdalena Bałkowiec, Radosław Maksym, Joanna Jacko, Monika Grymowicz, Paweł Włodarski
    Academic press:
    F1000Research (rok: 2018, tom: 7, strony: 1805), Wydawca: F1000 Research Ltd
    Status:
    Published
    DOI:
    10.7490/f1000research.1116301.1 - link to the publication
  1. Hypoxia normalization prevents endometriosis development.
    Authors:
    Radosław Maksym, M. Balkowiec, J. Malejczyk, C. Kieda, P. Włodarski.
    Conference:
    The International Society Of Gynecological Endocrinology (rok: 2016, ), Wydawca: Taylor and Francis
    Data:
    konferencja 2-5.03.2016
    Status:
    Published
  2. Effect of long-term SPRM treatment on endometrium.
    Authors:
    Magdalena Balkowiec, Radosław Maksym, Włodzimierz Baranowski, Jacek Doniec, Paweł Włodarski
    Conference:
    The International Society Of Gynecological Endocrinology (rok: 2016, ), Wydawca: Taylor and Francis
    Data:
    konferencja 2-5.03.2016
    Status:
    Published
  3. Hypoxia promotes endometriosis development affecting extracellular matrix turnover.
    Authors:
    R. Maksym, W. Baranowski, J. Malejczyk, C. Kieda, P. Włodarski
    Conference:
    16th World Congress on Human Reproduction (rok: 2015, ), Wydawca: International Academy of Human Reproduction
    Data:
    konferencja 18-21.03.2015
    Status:
    Published
  4. Methylation Profile of Inhibitors of Metalloproteinases in Endometriosis
    Authors:
    Magdalena Bałkowiec, Radosław Maksym, Joanna Jacko, Monika Grymowicz, Paweł Włodarski
    Conference:
    17th World Congress of the Academy of Human Reproduction (rok: 2017, ), Wydawca: International Academy of Human Reproduction
    Data:
    konferencja 15-18.03.2017
    Status:
    Published
  1. Genetyczne uwarunkowania endometriozy
    Authors:
    Włodzimierz Baranowski, Radosław Maksym
    Book:
    Endometrioza, Diagnostyka i Leczenie - wydanie II poprawione (rok: 2015, tom: I, strony: 40-54), Wydawca: Edra Urban & Partner
    Status:
    Published
  2. Epigenetyczna regulacja inhibitorów metaloptoteinaz macierzy pozakomórkowej w endometriozie
    Authors:
    Radosław Maksym
    Book:
    Epigenetyczna regulacja inhibitorów metaloptoteinaz macierzy pozakomórkowej w endometriozie (rok: 2015, tom: I, strony: 1-158), Wydawca: Warszawski Uniwersytet Medyczny - rozprawa na stopień doktora nauk medycznych
    Status:
    Published
  3. Etiopatogeneza endometriozy – geny czy środowisko?
    Authors:
    Radosław B. Maksym, Włodzimierz Baranowski
    Book:
    Standardy diagnostyki i leczenia endometriozy (rok: 2020, tom: 1, strony: 45422), Wydawca: Medical Tribune Polska
    Status:
    Published