Projects funded by the NCN

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Next generation in vitro experimental model of melanoma for pharmacological studies

Call: OPUS 8 , Panel: NZ7

Principal investigator: prof. Małgorzata Ewa Czyż

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Efficacy, toxicity and immunogenicity of carriers made of bioengineered spider silk for targeted drug delivery

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Identification of proline metabolic pathway as a molecular target for experimental regulation of apoptosis/autophagy in ...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Jerzy Aleksander Pałka

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Research on human eosinophils as a potential therapeutic target.

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: Marek Rafał Grosicki

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

GPR18 orphan receptor. Search for the tools to investigate GPR18 as potential therapeutic target

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Farmaceutyczny

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Cross-talk between PXR and AR receptors in hormone-dependent cancers.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Niemira

Politechnika Gdańska, Wydział Chemiczny

Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Jolanta Sowa-Kućma

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Preparation and physico-chemical evaluation of mesoporous oxide matrices as carriers in a model of the implant to the bo...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Wiesław Stanisław Sawicki

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Evaluation of peroxiredoxins 1 and 2 along with the thioredoxin-thioredoxin reductase system as new therapeutic targets ...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

PHARMACOTHERAPY OF OSTEOARTHRITIS: TRPV1 AND CB1 RECEPTORS AND THEIR ENDOGENOUS LIGANDS AS NEW TARGETS FOR PHARMACOLOGIC...

Call: SONATA BIS 2 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Maria Starowicz-Bubak

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The group III metabotropic glutamate receptors as a target for future antypsychotic drugs

Call: MAESTRO 3 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop...

Call: MAESTRO 3 , Panel: NZ4

Principal investigator: prof. Barbara Elżbieta Przewłocka

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

PIM kinases as rational therapeutic targets in lymphoid malignancies.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

The role of EZH2 activity in the development of resistance to targeted therapy in melanoma

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr Michał Jerzy Woźniak

Uniwersytet Medyczny w Łodzi

Selective autophagy-mediated protein degradation as a potential therapeutic strategy for the treatment of inflammatory c...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Monika Emilia Marcinkowska

Uniwersytet Jagielloński

The Potential of Mycobacterium tuberculosis Phase-Specific Antigens for Targeted TB Diagnosis

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Shima Mahmoudi

Politechnika Śląska

Disruption of the posttranslational activation of the translation factor EF-P as a new target for antimicrobial agents.

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr Piotr Wilk

Uniwersytet Jagielloński

Small molecule modulators of the tumor necrosis factor alpha signaling pathway for the inhibition of inflammatory proces...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Tadeusz Holak

Uniwersytet Gdański

Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Katarzyna Anna Malarz

Politechnika Śląska

Restoring Beta-cell Integrity through Targeted SPOP Inhibition and PDX-1 Preservation

Call: OPUS 26 (LAP) , Panel: NZ7

Principal investigator: dr Anna Czarna

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Danuta Dudzik

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

PROteolysis TArgeting Chimeras (PROTACs) intended to knock down excessive amyloidogenic proteins, human islet amyloid po...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Elżbieta Jankowska

Uniwersytet Gdański, Wydział Chemii

The inhibition of NMDAR and TRPM4 coupling - a hope for novel therapeutic target for the treatment of the ischemic brain...

Call: SONATA BIS 13 , Panel: NZ7

Principal investigator: dr Bartosz Sebastian Pomierny

Uniwersytet Jagielloński, Collegium Medicum

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej Polskiej Akademii Nauk

Curdlan-based biomaterial as a nanostructure carrier for controlled and targeted drug delivery in the treatment of deep ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: dr Aleksandra Nurzyńska

Uniwersytet Medyczny w Lublinie

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Anna Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: dr Alicja Małgorzata Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Tycjan Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Marek Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Adam Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Research on the preparation of new, hydrogel nanosystems for targeted therapy of colorectal cancer

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Urszula Helena Piotrowska

Warszawski Uniwersytet Medyczny

Customized DNA-based nanocarriers to boost heart healing

Call: WEAVE-UNISONO , Panel: NZ7

Principal investigator: dr Monika Bzowska

Uniwersytet Jagielloński

Gaining control on XBP1s signaling as a starting point for novel cancer therapies

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Rafał Artur Bartoszewski

Uniwersytet Wrocławski, Wydział Biotechnologii

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Karolina Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Brain-targeted β‐hydroxy-β‐methylbutyrate administration in the prevention of insulin resistance development in the hypo...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Elżbieta Supruniuk

Uniwersytet Medyczny w Białymstoku

A smart stride for cancer: synergistic effect of co-delivery chemo- andphototherapeutic agents using magneto-fluorescent...

Call: POLONEZ BIS 2 , Panel: NZ7

Principal investigator: dr Prachi Uttam Ghoderao

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Łukasz Kurach

Uniwersytet Medyczny w Lublinie

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Anna Daniel

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Anna Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Katarzyna Florczak-Substyk

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Marek Arkadiusz Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Justyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Aleksandra Sałat

Uniwersytet Jagielloński, Collegium Medicum

Specific Targeting of Antimicrobial Resistant Strains in situ using Targeted-Antibacterial-Plasmids

Call: CHIST-ERA2020 , Panel: NZ7

Principal investigator: dr Anna Marzec-Grządziel

Instytut Uprawy Nawożenia i Gleboznawstwa - Państwowy Instytut Badawczy

Mechanisms involved in heme acquisition - potential targets for therapies directed towards reduction of Porphyromonas gi...

Call: OPUS 21 , Panel: NZ6

Principal investigator: dr Michał Sylwester Śmiga

Uniwersytet Wrocławski, Wydział Biotechnologii