Projects funded by the NCN

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Next generation in vitro experimental model of melanoma for pharmacological studies

Call: OPUS 8 , Panel: NZ7

Principal investigator: prof. Małgorzata Czyż

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Efficacy, toxicity and immunogenicity of carriers made of bioengineered spider silk for targeted drug delivery

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr hab. Hanna Dams-Kozłowska

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Identification of proline metabolic pathway as a molecular target for experimental regulation of apoptosis/autophagy in ...

Call: OPUS 7 , Panel: NZ7

Principal investigator: prof. Jerzy Pałka

Uniwersytet Medyczny w Białymstoku, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Research on human eosinophils as a potential therapeutic target.

Call: PRELUDIUM 7 , Panel: NZ7

Principal investigator: Marek Grosicki

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

GPR18 orphan receptor. Search for the tools to investigate GPR18 as potential therapeutic target

Call: OPUS 6 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Inhibition of p21-Activated Kinase (PAK) as a new molecular target in the treatment of chronic myeloid leukemia (CML)

Call: OPUS 6 , Panel: NZ7

Principal investigator: dr hab. Sylwia Flis

Narodowy Instytut Leków

Cross-talk between PXR and AR receptors in hormone-dependent cancers.

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Niemira

Politechnika Gdańska, Wydział Chemiczny

Transcription factor MeCP2 as an intracellular object of study on the mechanism of depression and as a potential pharmac...

Call: SONATA 5 , Panel: NZ7

Principal investigator: dr Magdalena Sowa-Kućma

Instytut Farmakologii PAN

Preparation and physico-chemical evaluation of mesoporous oxide matrices as carriers in a model of the implant to the bo...

Call: OPUS 4 , Panel: NZ7

Principal investigator: prof. Wiesław Sawicki

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Evaluation of peroxiredoxins 1 and 2 along with the thioredoxin-thioredoxin reductase system as new therapeutic targets ...

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

DNA double-stranded break repair proteins as a target for personalized cancer therapy based on synthetic lethality

Call: OPUS 4 , Panel: NZ7

Principal investigator: dr hab. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

PHARMACOTHERAPY OF OSTEOARTHRITIS: TRPV1 AND CB1 RECEPTORS AND THEIR ENDOGENOUS LIGANDS AS NEW TARGETS FOR PHARMACOLOGIC...

Call: SONATA BIS 2 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Starowicz-Bubak

Instytut Farmakologii PAN

The group III metabotropic glutamate receptors as a target for future antypsychotic drugs

Call: MAESTRO 3 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii PAN

Activation of endogenous pronociceptive mechanisms of opioid system as an important factors in the development of neurop...

Call: MAESTRO 3 , Panel: NZ4

Principal investigator: prof. Barbara Przewłocka

Instytut Farmakologii PAN

PIM kinases as rational therapeutic targets in lymphoid malignancies.

Call: OPUS 2 , Panel: NZ4

Principal investigator: dr hab. Przemysław Juszczyński

Instytut Hematologii i Transfuzjologii

Directed screening and evaluation of novel bactericidal compounds active againsttubercle bacilli and Mycobacterium absce...

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Jarosław Dziadek

Instytut Biologii Medycznej Polskiej Akademii Nauk

Curdlan-based biomaterial as a nanostructure carrier for controlled and targeted drug delivery in the treatment of deep ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Aleksandra Nurzyńska

Uniwersytet Medyczny w Lublinie

Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marika Frańczak

Gdański Uniwersytet Medyczny, Wydział Lekarski

Endothelial bioenergetics as a novel target for vascular protection – unveiling the mitochondrial mechanisms of lipid-lo...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Alicja Braczko

Gdański Uniwersytet Medyczny, Wydział Lekarski

Understanding the influence of structure and functionalisation of nanocarriers for targeted drug delivery on cell-nanost...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Karolina Krajewska

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu

The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Sylwester Mosiołek

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Targeted inhibition of hypusination pathway

Call: OPUS 24 , Panel: NZ7

Principal investigator: dr Przemysław Grudnik

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Targeted poloxamer micelles with selected drugs as a strategy for overcoming the mechanisms of multidrug resistance in p...

Call: PRELUDIUM BIS 4 , Panel: NZ7

Principal investigator: prof. Tomasz Gośliński

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Research on the preparation of new, hydrogel nanosystems for targeted therapy of colorectal cancer

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Urszula Piotrowska

Warszawski Uniwersytet Medyczny

Gaining control on XBP1s signaling as a starting point for novel cancer therapies

Call: OPUS 24 , Panel: NZ7

Principal investigator: prof. Rafał Bartoszewski

Uniwersytet Wrocławski, Wydział Biotechnologii

A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

Call: OPUS 24 (LAP) , Panel: NZ7

Principal investigator: dr hab. Anna Więckowska

Uniwersytet Jagielloński, Collegium Medicum

Brain-targeted β‐hydroxy-β‐methylbutyrate administration in the prevention of insulin resistance development in the hypo...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Elżbieta Supruniuk

Uniwersytet Medyczny w Białymstoku

A smart stride for cancer: synergistic effect of co-delivery chemo- andphototherapeutic agents using magneto-fluorescent...

Call: POLONEZ BIS 2 , Panel: NZ7

Principal investigator: dr Prachi Ghoderao

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Łukasz Kurach

Uniwersytet Medyczny w Lublinie

Brain cytochrome P450 as a new target for the treatment of neurological and psychiatric diseases. Studies with human neu...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Władysława Daniel

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Szczepańska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Kaczor

Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

Call: SONATA 17 , Panel: NZ7

Principal investigator: dr Anna Florczak

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Light-producing, oxygen-delivering, cancer cell-targeted carriers for photosensitisers dedicated for photodynamic therap...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Marek Murias

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a...

Call: OPUS 22 , Panel: NZ7

Principal investigator: prof. Katarzyna Kieć-Kononowicz

Uniwersytet Jagielloński, Collegium Medicum

Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

Call: OPUS 22 (LAP) , Panel: NZ7

Principal investigator: prof. Kinga Sałat

Uniwersytet Jagielloński, Collegium Medicum

Mechanisms involved in heme acquisition - potential targets for therapies directed towards reduction of Porphyromonas gi...

Call: OPUS 21 , Panel: NZ6

Principal investigator: dr Michał Śmiga

Uniwersytet Wrocławski, Wydział Biotechnologii

Synthetic epidermal growth factor receptor inhibitor conjugated with nobel metal nanoparticles as a potential drug for t...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Shaoshan Mai

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

In search for molecular targets to overcome doxorubicin resistance in triple-negative breast cancer with the use of inno...

Call: PRELUDIUM 20 , Panel: NZ7

Principal investigator: Anna Pogorzelska

Narodowy Instytut Leków

Enzymes of the L-methionine biosynthetic pathway as novel moleculartargets for antifungal chemotherapy

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Iwona Gabriel

Politechnika Gdańska, Wydział Chemiczny

The study on the molecular mechanisms of cytotoxic activity of new compounds ZOT5-1-Me and ZOT5-1-Et in an experimental ...

Call: SONATA 16 , Panel: NZ7

Principal investigator: dr Paulina Tokarz

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Drug repurposing to target p53 protein family for improved therapy in the relapsed TP53 and EGFR mutated lung cancer

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr Joanna Zawacka-Pankau

Warszawski Uniwersytet Medyczny

Identification of potential markers aiming early diagnostics of progression and tailoring metastasis-oriented therapies ...

Call: OPUS 20 , Panel: NZ5

Principal investigator: dr Natalia Bednarz-Knoll

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

DNA polymerase θ as a novel therapeutic target in personalized anticancer therapy

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Tomasz Śliwiński

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

New multifunctional drug-like ligands focusing on molecular targets associated with the symptoms and causes of Alzheimer...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Anna Pasieka

Uniwersytet Jagielloński, Collegium Medicum

Novel approach in the search for asthma and COPD therapies - computer aided design of multi-target-directed ligands bloc...

Call: PRELUDIUM 19 , Panel: NZ7

Principal investigator: Alicja Gawalska

Uniwersytet Jagielloński, Collegium Medicum

Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic ...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Katarzyna Kuter

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Synthetic analogues of opioid growth factor linked to derivatives of glucosamine as a potential compounds for targeted t...

Call: OPUS 18 , Panel: NZ7

Principal investigator: dr hab. Iwona Inkielewicz-Stępniak

Gdański Uniwersytet Medyczny, Wydział Lekarski