Projects funded by the NCN

Modified nucleotide residues as potential tool to increase aptamer - target protein interaction

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Weronika Paulina Kotkowiak

Instytut Chemii Bioorganicznej PAN

Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Modified (oligo)nucleotides for photo-controlled manipulation of mRNA

Call: SONATA 18 , Panel: ST4

Principal investigator: dr Marcin Warmiński

Uniwersytet Warszawski, Wydział Fizyki

Radiosensitization by the combined use of modified nucleosides and inhibitors of DNA repair to improve the efficacy of r...

Call: SONATA 17 , Panel: ST4

Principal investigator: dr Magdalena Danuta Zdrowowicz-Żamojć

Uniwersytet Gdański, Wydział Chemii

Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleoside...

Call: OPUS 22 , Panel: ST4

Principal investigator: dr hab. Grażyna Bożena Leszczyńska

Politechnika Łódzka

Application of targeted metabolomic approach in quantitative prospective analysis of nucleosides profiles alterations be...

Call: PRELUDIUM 15 , Panel: NZ7

Principal investigator: Małgorzata Artymowicz

Gdański Uniwersytet Medyczny

Why Nature introduced selenium to wobble nucleosides in transfer RNA?

Call: OPUS 15 , Panel: ST5

Principal investigator: prof. Barbara Czesława Nawrot

Centrum Badań Molekularnych i Makromolekularnych PAN

Synthesis of trimethyl cap analogs modified with molecular rotors and their application in nuclear transport studies

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Błażej Wojtczak

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Synthesis and structural studies of oligonucleotides with tRNA anticodon stem-loop sequences containing newly discovered...

Call: OPUS 13 , Panel: ST5

Principal investigator: prof. Elżbieta Jadwiga Sochacka

Politechnika Łódzka, Wydział Chemiczny

Application of LCMS to quantitative analysis of composition of in vitro transcribed RNAs containing chemically modified ...

Call: PRELUDIUM 12 , Panel: ST4

Principal investigator: Dominika Strzelecka

Uniwersytet Warszawski, Wydział Fizyki

N-Oxide phosphobetaines in new synthetic strategies for P-modified phosphates and polyphospates of natural biomolecules ...

Call: PRELUDIUM 12 , Panel: ST5

Principal investigator: Magdalena Materna

Instytut Chemii Bioorganicznej PAN

Chemically modified mRNA for studies on cellular processes and therapeutic applications

Call: OPUS 11 , Panel: ST5

Principal investigator: prof. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Look at the mechanism of ovarian cancer cells response to adenine nucleosides modified with metallacarborane clusters wi...

Call: OPUS 9 , Panel: NZ3

Principal investigator: dr Katarzyna Bednarska

Instytut Biologii Medycznej PAN

New nucleotide analogs containing triazole within oligophosphate bridge as mimics of the 5' end of mRNA - synthesis, pro...

Call: PRELUDIUM 9 , Panel: ST5

Principal investigator: Sylwia Ciechanowicz

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

From a molecular in silico model to cellular response in vitro. Modified nucleosides as photo and/or radiosensitizers of...

Call: MAESTRO 6 , Panel: ST4

Principal investigator: prof. Janusz Adam Rak

Uniwersytet Gdański, Wydział Chemii

Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the in...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Michał Robert Matuszewski

Politechnika Łódzka, Wydział Chemiczny

Biosynthesis of seleno-modified nucleosides in the anticodon loop of transfer ribonucleic acids. Evaluation of the enzym...

Call: OPUS 7 , Panel: ST5

Principal investigator: prof. Barbara Czesława Nawrot

Centrum Badań Molekularnych i Makromolekularnych PAN

Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

Call: SONATA BIS 3 , Panel: NZ1

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

Isosterically modified acyclic nucleoside phosphonates

Call: OPUS 5 , Panel: NZ7

Principal investigator: prof. Andrzej Edward Wróblewski

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

Synthesis and study of spectroscopic and bilogical properties of nucleosides modyfied by new stilbene derivatives

Call: OPUS 4 , Panel: ST5

Principal investigator: dr hab. Przemysław Ryszard Szczeciński

Politechnika Warszawska, Wydział Chemiczny

Pronucloetides - a pathway to cellular DNA sensitization to ionizing radiation

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: Magdalena Danuta Zdrowowicz

Uniwersytet Gdański, Wydział Chemii

New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

Call: SONATA 3 , Panel: ST5

Principal investigator: dr hab. Anna Pasternak

Instytut Chemii Bioorganicznej PAN

New reagents and methods in synthesis of modified nucleotides and their application for preparation biochemical tools an...

Call: SONATA BIS 1 , Panel: ST5

Principal investigator: dr hab. Jacek Jemielity

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego