Projects funded by the NCN

Novel insights into inhibition of PD-L1/PD-1 immune checkpoint – discovery and optimization of covalent PD-L1 inhibitors...

Call: SONATA 20 , Panel: ST5

Principal investigator: dr Radosław Dariusz Kitel

Uniwersytet Jagielloński

Heterogeneity immunocompetent cells during chimeric antigen receptor T cell (CAR-T) CD19 immunotherapy.

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Aleksandra Maria Oszer

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Multiparameter analysis of co-inhibitory and co-stimulatory immune checkpoints and their role in the induction of immuno...

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Dorota Suszczyk

Uniwersytet Medyczny w Lublinie

Development of novel anti-cancer immunotherapy against mesothelioma comprising of oncolytic adenovirus vectors armed wit...

Call: SONATA 18 , Panel: NZ7

Principal investigator: dr Łukasz Kuryk

Narodowy Instytut Zdrowia Publicznego PZH - Państwowy Instytut Badawczy

Role of microparticles derived from platelets and cancer cells in colorectal cancer progression – how to stop them or tu...

Call: OPUS 24 , Panel: NZ5

Principal investigator: prof. Maria Anna Kowalska

Instytut Biologii Medycznej Polskiej Akademii Nauk

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Impact of the CDK4/6 targeted degradation by PROTACs on immune checkpoint signaling in cancer

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr Katarzyna Magiera-Mularz

Uniwersytet Jagielloński, Wydział Chemii

New immunomodulators of BTLA-HVEM complex as potential therapeutics in systemic lupus erythematosus

Call: OPUS 22 , Panel: NZ7

Principal investigator: dr hab. Anna Wardowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

The role of the immune checkpoints in the pathomechanism of depressive disorders.

Call: OPUS 22 , Panel: NZ6

Principal investigator: prof. Marta Wanda Kubera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Photoswitchable and chimeric molecules for spatially restricted and endoplasmic reticulum-specific blockade of PD-L1 pro...

Call: SONATA BIS 11 , Panel: NZ7

Principal investigator: dr Łukasz Dariusz Skalniak

Uniwersytet Jagielloński, Wydział Chemii

The SAR analysis and synthesis of complex, small molecule PD-1/PD-L1 interaction antagonists

Call: PRELUDIUM 20 , Panel: ST4

Principal investigator: Magdalena Maria Żarnik

Uniwersytet Jagielloński, Wydział Chemii

The clinical significance of immunosuppression in ovarian cancer microenvironments

Call: PRELUDIUM 20 , Panel: NZ6

Principal investigator: dr Anna Maria Pawłowska-Łachut

Uniwersytet Medyczny w Lublinie

Single cell multi-omics in defining how specific oncogenic alterations shape the immune microenvironment and responses t...

Call: OPUS 20 , Panel: NZ4

Principal investigator: prof. Bożena Kamińska-Kaczmarek

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Photodynamic therapy combined with PD-1/PD-L1 blockade immunotherapy: new possibilities for the treatment of immunogenic...

Call: OPUS 19 , Panel: NZ7

Principal investigator: dr hab. Janusz Marcin Dąbrowski

Uniwersytet Jagielloński, Wydział Chemii

Development of a three-dimensional in vitro model for studying the mechanisms of immunostimulatory activity of PD-1/PD-L...

Call: PRELUDIUM 18 , Panel: NZ5

Principal investigator: Justyna Natalia Kocik-Król

Uniwersytet Jagielloński, Wydział Chemii

The immune checkpoints in non-small cell lung cancer - research on genetic and epigenetic mechanism regulating mRNA and ...

Call: OPUS 17 , Panel: NZ5

Principal investigator: dr hab. Monika Jasek

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Marcelina Spodzieja

Uniwersytet Gdański, Wydział Chemii

Structural and functional analysis of immune checkpoints

Call: OPUS 13 , Panel: NZ1

Principal investigator: prof. Grzegorz Dubin

Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

Evaluation of the anticancer efficacy of a new chimeric antigen receptor targeting PD-L1 molecule

Call: OPUS 12 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny, Wydział Lekarski

The role of arginase-1 in antitumor efficacy of cancer immunotherapy using checkpoint inhibitors

Call: OPUS 12 , Panel: NZ6

Principal investigator: prof. Dominika Anna Nowis

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego