Projects funded by the NCN

First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

Call: OPUS 26 , Panel: NZ7

Principal investigator: prof. Jadwiga Handzlik

Uniwersytet Jagielloński, Collegium Medicum

Protease-induced neutrophilic networks in cancer development.

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Danuta Teresa Bryzek

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Integrated multi-omics approach to accelerate anticancer drug discovery by targeting metabolic reprogramming in human co...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr hab. Danuta Dudzik

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Proteolytic processing of adhesion G-protein coupled receptors through proteases

Call: WEAVE-UNISONO , Panel: NZ1

Principal investigator: dr Renata Katarzyna Mężyk-Kopeć

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

Evaluation of P2X7 purinergic receptor as a trigger of brain metabolic abnormalities and neuronal degeneration in a mous...

Call: SONATA BIS 13 , Panel: NZ4

Principal investigator: dr Anna Wilkaniec

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Actin cytoskeleton disorders as a pro-survival signaling activator and a therapeutic biomarker in Diffuse Large B-cell L...

Call: SONATA BIS 13 , Panel: NZ5

Principal investigator: dr Patryk Górniak

Instytut Hematologii i Transfuzjologii

Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Study on novel sensing layers for determination of quorum sensing signal molecules

Call: SONATA BIS 13 , Panel: ST5

Principal investigator: dr hab. Kamila Sadowska

Instytut Biocybernetyki i Inżynierii Biomedycznej im. Macieja Nałęcza PAN

Crownphyrins - hybrids of crown ethers and porphyrins, constituting macrocyclic platforms for the construction of two- a...

Call: PRELUDIUM BIS 5 , Panel: ST4

Principal investigator: dr hab. Bartosz Jakub Szyszko

Uniwersytet Wrocławski, Wydział Chemii

The role of free fatty acid receptors in pathophysiology of the functional gastrointestinal tract disorders: new therapi...

Call: PRELUDIUM BIS 5 , Panel: NZ7

Principal investigator: dr hab. Maciej Stanisław Sałaga

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Unraveling protease activation in stimulated CAR-T cells to identify new biomarkers for assessing their clinical efficac...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Małgorzata Firczuk

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Heterogeneity immunocompetent cells during chimeric antigen receptor T cell (CAR-T) CD19 immunotherapy.

Call: PRELUDIUM 22 , Panel: NZ6

Principal investigator: Aleksandra Maria Oszer

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Wojciech Kamysz

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

The cross-talk between 5-HTR2A and mGluR2 as a window for antidepressant effects of psilocybin.

Call: OPUS 25 , Panel: NZ7

Principal investigator: prof. Andrzej Mikołaj Pilc

Instytut Farmakologii PAN

Targeting the serotonin 5-HT7 receptor in a search for new strategies of mental disorders treatment

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Patryk Pyka

Uniwersytet Jagielloński, Collegium Medicum

Molecular geometry – pre- and post-synthetically modified shape-persistent macrocycles of great chiroptical response, fo...

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Marcin Grzegorz Kwit

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

Call: OPUS 25 , Panel: NZ3

Principal investigator: dr Daria Paulina Zdżalik-Bielecka

Uniwersytet Warszawski, Wydział Biologii

"I like to move it, move it" – molecular dynamics-driven optimization of ligand residence time as an opportunity to impr...

Call: OPUS 25 , Panel: NZ7

Principal investigator: dr hab. Sabina Marta Podlewska

Instytut Farmakologii PAN

Are bisphenol S and F safe substitutes for bisphenol A in the face of environmental contamination with estrogenic mycoto...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Marta Justyna Kozieł

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Myeloid cell subpopulations as a source of effector cells for anticancer therapies using CAR chimeric receptors

Call: OPUS 25 , Panel: NZ6

Principal investigator: dr hab. Angelika Muchowicz

Warszawski Uniwersytet Medyczny, Wydział Lekarski

Efektywność nowatorskiej terapii inhibitorami JAK u pacjentów z reumatoidalnym zapaleniem stawów w odniesieniu do profil...

Call: PRELUDIUM 22 , Panel: NZ5

Principal investigator: Sylwia Anna Biały

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian b...

Call: PRELUDIUM 22 , Panel: NZ7

Principal investigator: Bernadeta Angelika Pietrzak-Wawrzyńska

Instytut Farmakologii PAN

Elucidating the role of SorLA receptor in shaping immunosuppressive character of glioma microenvironment

Call: PRELUDIUM 22 , Panel: NZ4

Principal investigator: Paulina Kinga Kamińska

Uniwersytet Warszawski, Wydział Biologii

Psychedelic-induced molecular changes in the brain

Call: SONATINA 7 , Panel: NZ2

Principal investigator: dr Dominik Łukasz Cysewski

Uniwersytet Medyczny w Białymstoku

Participation of exosomes secreted by neutrophils in the modulation of angiogenesis - the role of the type 1 interferon ...

Call: SONATINA 7 , Panel: NZ5

Principal investigator: dr Mateusz Piotr Smolarz

Akademia Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach

EBI2 receptor as a new myelin repair therapy in multiple sclerosis.

Call: SONATA 18 , Panel: NZ3

Principal investigator: dr hab. Aleksandra Rutkowska

Gdański Uniwersytet Medyczny, Wydział Lekarski

Electron-Deficient Cyclophanes and Annulenes. Functional Aromatics in Two and Three Dimensions

Call: OPUS 24 , Panel: ST4

Principal investigator: prof. Marcin Łukasz Stępień

Uniwersytet Wrocławski, Wydział Chemii

Mitigation of climate change effect on crop plants' immunity by engineering the thermostability of plant immune receptor...

Call: OPUS 24 , Panel: NZ9

Principal investigator: dr Marta Karolina Grech-Baran

Instytut Biochemii i Biofizyki PAN

Investigating the role of fibroblast growth factor receptors and STAT transcription factors in the targeted therapy of a...

Call: PRELUDIUM BIS 4 , Panel: NZ5

Principal investigator: prof. Ewa Teresa Marcinkowska

Uniwersytet Wrocławski, Wydział Biotechnologii

Function, organization, dynamics, and evolution of hyperbranched receptor-binding protein systems in Klebsiella jumbo ph...

Call: OPUS 24 (LAP) , Panel: NZ1

Principal investigator: prof. Zuzanna Drulis-Kawa

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

The effect of glyphosate exposure on morphology, innervation and contractility of the uterus in sexually immature gilts.

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Aleksandra Angelika Karpiesiuk

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Medycyny Weterynaryjnej

Searching for natural bioactive farnesoid X receptor agonists and their role in parenteral nutrition-associated liver di...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr hab. Maciej Jan Stawny

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

Studies on the post-receptor mechanisms of TSPO in search of a novel therapeutic target of metabolic syndrome

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Łukasz Kurach

Uniwersytet Medyczny w Lublinie

The role of lipoproteins and lipoprotein receptors in mediating the effects of childhood trauma on the brain and the ger...

Call: PRELUDIUM 21 , Panel: NZ3

Principal investigator: Weronika Tomaszewska

Sieć Badawcza ŁUKASIEWICZ - PORT Polski Ośrodek Rozwoju Technologii

Molecular implications of gut microbiota disorders in the context of the immune system functioning in patients with prim...

Call: OPUS 23 , Panel: NZ6

Principal investigator: prof. Ewelina Pia Grywalska

Uniwersytet Medyczny w Lublinie

NANO-HORMESIS: Nanoparticle-mediated Hormetic Dose Response in Hypericumspecies: How do plants perceive engineered metal...

Call: OPUS 23 , Panel: NZ9

Principal investigator: dr hab. Franklin Gregory

Instytut Genetyki Roślin PAN

The role of simultaneous and individual modulation of μ-opioid, sigma-1 and histamine H3 receptors as a new therapeutic ...

Call: OPUS 23 , Panel: NZ7

Principal investigator: dr Katarzyna Anna Szczepańska

Instytut Farmakologii PAN

Adaptations of proprioceptive input from muscle spindles to motoneurons in response to strength and endurance training

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Piotr Andrzej Krutki

Akademia Wychowania Fizycznego im. Eugeniusza Piaseckiego w Poznaniu

Proinsulin C-peptide and G protein-coupled receptor 146 (GPR146) – clinical investigation of the impact of their signall...

Call: PRELUDIUM 21 , Panel: NZ4

Principal investigator: Aleksandra Ryk

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Allosteric and allosteric-orthosteric bitopic ligands of histamine receptor H4 as a way to increase selectivity and bias...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Sławomir Hubert Filipek

Uniwersytet Warszawski, Wydział Chemii

Highly-internalizing intrinsically fluorescent oligomeric cytotoxic conjugate targeting breast cancer cells overproducin...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: dr Natalia Porębska

Uniwersytet Wrocławski, Wydział Biotechnologii

The effect of chronic administration of purine P1-A2B receptor agonist, using electrospun microfibers, on intrarenal blo...

Call: PRELUDIUM 21 , Panel: NZ5

Principal investigator: Joanna Dorota Sitek-Dębska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Use of comparative oncology approach to dissect the PD-1 intrinsic signalling in osteosarcoma. Can dog be the key for ne...

Call: PRELUDIUM 21 , Panel: NZ1

Principal investigator: Katarzyna Joanna Dziubek

Uniwersytet Gdański, Międzynarodowe Centrum Badań nad Szczepionkami Przeciwnowotworowymi

Soluble scavenger receptor cysteine-rich domain-containing protein - SSc5D, a new player of innate immunity in turkey (M...

Call: OPUS 23 , Panel: NZ9

Principal investigator: dr hab. Mariola Słowińska

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Yin and Yang effect of P2X and P1 purinergic receptors on compartment of hematopoietic stem cells

Call: OPUS 23 , Panel: NZ3

Principal investigator: prof. Magdalena Józefa Kucia

Warszawski Uniwersytet Medyczny

Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer's disease

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Karolina Barbara Przepiórska-Drońska

Instytut Farmakologii PAN

The evaluation of therapeutic potential of β-caryophyllene in animal schizophrenia model - behavioral and molecular stud...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: dr Magdalena Białoń

Instytut Farmakologii PAN

Combination of FAAH inhibition with action via serotonin 5-HT6 receptor as pioneering approach to fight with Alzheimer D...

Call: PRELUDIUM 21 , Panel: NZ7

Principal investigator: Kinga Maria Czarnota-Łydka

Uniwersytet Jagielloński, Collegium Medicum

Genetics of GR-dependent behavioral traits in humans

Call: OPUS 23 , Panel: NZ5

Principal investigator: dr hab. Michał Korostyński

Instytut Farmakologii PAN

mRNA export regulation during global poly(A)RNA nuclear retention in plant cells.

Call: PRELUDIUM 21 , Panel: NZ3

Principal investigator: Karolina Monika Majewska

Uniwersytet Mikołaja Kopernika, Wydział Nauk Biologicznych i Weterynaryjnych