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Yin and Yang effect of P2X and P1 purinergic receptors on compartment of hematopoietic stem cells

2022/45/B/NZ3/00476

Keywords:

hematopoietic stem cells purinergic signaling P2X purinergic receptors P1 receptors

Descriptors:

  • NZ3_8: Stem cell biology
  • NZ3_2: Cell physiology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Warszawski Uniwersytet Medyczny

woj.

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Józefa Kucia 

Number of co-investigators in the project: 5

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 2 859 680 PLN

Project start date (Y-m-d): 2023-02-15

Project end date (Y-m-d): 2027-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner
    Authors:
    Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A, Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M
    Academic press:
    Leukemia (rok: 2023, tom: 37, strony: 1401-1405), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-023-01894-0 - link to the publication
  2. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots
    Authors:
    Ratajczak MZ, Bujko K, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 1, strony: 45669), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 - link to the publication
  3. External Liver-Derived Complement and Intrinsic Present in Hematopoietic Stem/Progenitor Cells Complosome Modulate Cell Metabolism and Response to Stress
    Authors:
    Thapa A, Ratajczak J, Kucia M, Ratajczak MZ
    Academic press:
    Stem cell reviews and reports (rok: 2023, tom: 19, strony: 1177-1184), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-023-10533-1 - link to the publication

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