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Yin and Yang effect of P2X and P1 purinergic receptors on compartment of hematopoietic stem cells

2022/45/B/NZ3/00476

Keywords:

hematopoietic stem cells purinergic signaling P2X purinergic receptors P1 receptors

Descriptors:

  • NZ3_008:
  • NZ3_002:
  • NZ3_001:

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Józefa Kucia 

Number of co-investigators in the project: 5

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 2 859 680 PLN

Project start date (Y-m-d): 2023-02-15

Project end date (Y-m-d): 2027-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (15)
  1. Optimizing single cell RNA sequencing of stem cells. A streamlined workflow for enhanced sensitivity and reproducibility in hematopoietic studies. The use of human umbilical cord blood-derived hematopoietic stem and progenitor cells
    Authors:
    Jarczak, J., Kieszek, P., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Frontiers in cell and developmental biology (rok: 2025, tom: 13, strony: 1590889), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2025.1590889 - link to the publication
  2. The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells
    Authors:
    Konopko, A., Łukomska, A., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 21, strony: 59-67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10792-6 - link to the publication
  3. The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism
    Authors:
    Konopko, A., Kazek, M., Waraksa-Zasada, E., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 21, strony: 2157-2169), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10948-y - link to the publication
  4. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots
    Authors:
    Ratajczak MZ, Bujko K, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 1, strony: 46034), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 - link to the publication
  5. Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) by Downregulating Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) Activity
    Authors:
    Abdelbaset-Ismail, A., Brzezniakiewicz-Janus, K., Thapa, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20(1), strony: 237-246), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10638-7 - link to the publication
  6. Complosome Activation after Myocardial Infarction in a Murine Model of Permanent LAD Ligation
    Authors:
    Ratajczak, J., Abdel-Latif, A., Schneider, G., Luther, T., Chaudhary, R., Shabani, P., Lopez, R., Alzamrooni, A., Singh, A. P., Jama, H., Kakar, S. S., Kucia, M., & Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (rok: 2026, tom: 22, strony: 1023-1029), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-11044-x - link to the publication
  7. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots
    Authors:
    Ratajczak, M. Z., Bujko, K., Brzezniakiewicz-Janus, K., Ratajczak, J., & Kucia, M.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20(3), strony: 827-838), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 - link to the publication
  8. Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient.
    Authors:
    Bujko, K., Brzezniakiewicz-Janus, K., Jarczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 20 (5), strony: 1357-1366), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10716-4 - link to the publication
  9. UDP-Glucose-P2Y14 Receptor Signaling Enhances the Responsiveness of Hematopoietic Stem/Progenitor Cells to Chemoattractants by Facilitating Membrane Lipid Raft Formation and Nlrp3 Inflammasome Activation
    Authors:
    Adamiak, M., Thetchinamoorthy, K., Wierzbicka, D., Kazek, M., Waraksa-Zasada, E., Lukomska, A., Brzezniakiewicz-Janus, K., Ratajczak, J., Kucia, M., & Z Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (rok: 2026, tom: 26, strony: s12015), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-026-11104-w - link to the publication
  10. NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility
    Authors:
    Thetchinamoorthy, K., Wierzbicka, D., Waraksa-Zasada, E., Kazek, M., Konopko, A., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Redox biology (rok: 2025, tom: 88, strony: 103948), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2025.103948 - link to the publication
  11. Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner
    Authors:
    Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A, Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M
    Academic press:
    Leukemia (rok: 2023, tom: 37, strony: 1401-1405), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-023-01894-0 - link to the publication
  12. External Liver-Derived Complement and Intrinsic Present in Hematopoietic Stem/Progenitor Cells Complosome Modulate Cell Metabolism and Response to Stress
    Authors:
    Thapa A, Ratajczak J, Kucia M, Ratajczak MZ
    Academic press:
    Stem cell reviews and reports (rok: 2023, tom: 19, strony: 1177-1184), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-023-10533-1 - link to the publication
  13. Intracellular Complement (Complosome) is Expressed in Several Types of Human Adult Bone Marrow-Derived Stem Cells
    Authors:
    Bujko, K., Brzenziakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 21(1), strony: 437-439), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10650-x - link to the publication
  14. Complosome Regulates Hematopoiesis at the Mitochondria Level
    Authors:
    Konopko, A., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 10,1007, strony: s12015-025), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10856-1 - link to the publication
  15. Defect in Migration of HSPCs in Nox-2 Deficient Mice Explained by Impaired Activation of Nlrp3 Inflammasome and Impaired Formation of Membrane Lipid Rafts
    Authors:
    Bujko, K., Adamiak, M., Konopko, A., Chumak, V., Ratajczak, J., Brzezniakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 21(1), strony: 45-58), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10775-7 - link to the publication

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