Projects funded by the NCN

Dioscuri Center for Structural Dynamics of Receptors

Call: DIOSCURI 4 , Panel: NZ1

Principal investigator: Przemysław Nogły

Uniwersytet Jagielloński

GLP-1R activation as an approach to modulate the effects of HHV-1 on neuronal functions – studies in mouse astrocytes

Call: PRELUDIUM 24 , Panel: NZ5

Principal investigator: Adrianna Niedzielska

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie

Role of the BRM- ERα interaction in the conferring of resistance to paclitaxel in BRG1-deficient cancers

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Karolina Gronkowska

Uniwersytet Łódzki

Are RIG-I-Like Receptors the Key to Understanding Galliformes' Susceptibility to Pathogens? Investigating the Role of MD...

Call: OPUS 29 , Panel: NZ9

Principal investigator: dr hab. Paweł Jan Sikorski

Uniwersytet Warszawski

Flavonoid phytoprogestins as novel non-steroidal progesterone receptor modulators in a nutraceutical approach to endomet...

Call: PRELUDIUM 24 , Panel: NZ9

Principal investigator: Agata Gołąbek-Grenda

Uniwersytet Przyrodniczy w Poznaniu

Dual-acting 5-HT6/5-HT7 receptor antagonists: exploring beneficial effects for the treatment of neurodegenerative disord...

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Michał Kamiński

Uniwersytet Jagielloński

Personalized selective activation of γδT Vδ2 cells using zoledronic acid for glioblastoma MICA/Bhigh therapy: in vitro a...

Call: PRELUDIUM 24 , Panel: NZ4

Principal investigator: Natalia Anna Lehman

Uniwersytet Medyczny w Lublinie

The impact of H3 histamine receptor modulation on oligodendrogenesis and neurogenesis: a new strategy for the treatment ...

Call: PRELUDIUM 24 , Panel: NZ5

Principal investigator: Maciej Degutis

Instytut Farmakologii PAN

The role of the P2X4 purinergic receptor in regulating mitochondrial metabolism and redox homeostasis in hematopoietic s...

Call: PRELUDIUM 24 , Panel: NZ3

Principal investigator: Magda Molenda

Warszawski Uniwersytet Medyczny

Elimination of IgE-producing cells using next-generation chimeric antigen receptor (CAR)-based therapy

Call: OPUS 29 , Panel: NZ6

Principal investigator: dr hab. Beata Kaleta

Warszawski Uniwersytet Medyczny

New approach to glioblastoma adoptive therapy based on inducible CAR expression system - SynCAR

Call: OPUS 29 , Panel: NZ6

Principal investigator: dr hab. Radosław Zagożdżon

Warszawski Uniwersytet Medyczny

Design and Pharmacological Evaluation of Marine Alkaloid-Inspired 5-HT2A Receptor Ligands

Call: PRELUDIUM 24 , Panel: NZ1

Principal investigator: Szymon Kazimierz Kordylewski

Instytut Farmakologii PAN

Synthesis of new macrocyclic molecular receptors with torand skeleton for selective and effective metal cation detection

Call: PRELUDIUM 24 , Panel: ST5

Principal investigator: Stanisław Marek Kulczyk

Politechnika Warszawska

NMR Spectroscopy as Molecular Language: A Deep Learning Approach to Bioactivity Prediction

Call: PRELUDIUM 24 , Panel: NZ7

Principal investigator: Arkadiusz Bogumił Leniak

Instytut Farmakologii PAN

Positioning the aryl hydrocarbon receptor (AhR) as a new target for pharmacotherapy of sporadic Alzheimer disease: verif...

Call: OPUS 28 , Panel: NZ7

Principal investigator: prof. Małgorzata Kajta

Instytut Farmakologii PAN

The influence of beta2-receptor N-terminal polymorphismsadrenergic on its functionality, interactions withdrugs and the ...

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Anita Elżbieta Płazińska

Uniwersytet Medyczny w Lublinie

Antibacterial molecules based on bacteriophage proteins and constant antibody fragments with therapeutic potential for t...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Karolina Aleksandra Filik-Matyjaszczyk

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Clinical Variants of Hsp70 Chaperone HSPA1L in Protein Folding and Regulation of Glucocorticoid Receptor

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Agnieszka Antonina Kłosowska

Uniwersytet Gdański

Cannabidiol as a Neuroprotective Therapy: Are Brain Regeneration Mechanisms After Perinatal Hypoxia-Ischemia Sex-Depende...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Hanna Kletkiewicz

Uniwersytet Mikołaja Kopernika

Modulating Neuroplasticity with Psilocybin: Assesment Therapeutic Potential in Treating Fentanyl use disorder

Call: OPUS 28 , Panel: NZ7

Principal investigator: dr hab. Ewa Taracha

Instytut Psychiatrii i Neurologii

Galanin as the modulator of glucocorticoid secretion and its role in Cushing's Disease.

Call: SONATA 20 , Panel: NZ3

Principal investigator: dr Beata Joanna Mossakowska

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

A triple agonist of glucagon, GLP-1, and GIP receptors as a novel therapeutic option for the treatment of heart failure ...

Call: SONATA 20 , Panel: NZ5

Principal investigator: dr Marta Katarzyna Oknińska

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Adopted orphan nuclear receptors as new regulators of testis immune privilege

Call: SONATA 20 , Panel: NZ3

Principal investigator: dr Alicja Kinga Kamińska

Uniwersytet Jagielloński

The role of bile acid receptor TGR5 in insulin-dependent regulation of podocyte function and glomerular filtration barri...

Call: SONATA 20 , Panel: NZ4

Principal investigator: dr Patrycja Rachubik

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Modulation of 5-HT7 receptor signaling as common mechanism involved in the long-lasting antidepressant effects of typica...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Barbara Wanda Chruścicka-Smaga

Instytut Farmakologii PAN

Application of bioconjugation strategy to the synthesis of anticancer Trojan horses

Call: OPUS 28 , Panel: ST5

Principal investigator: dr hab. Michał Piotr Antoszczak

Uniwersytet im. Adama Mickiewicza w Poznaniu

Effects of ketamine optical isomers on motivation and decision-making in rats using deep learning for behavioral analysi...

Call: SONATA 20 , Panel: NZ7

Principal investigator: dr Natalia Alicja Malikowska-Racia

Instytut Farmakologii PAN

Understanding the function of DTX3L ligase in an antiviral response induced by pattern recognition receptors (PRR).

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Jakub Maciej Siednienko

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

ERβ-mediated autophagy in colorectal cancer and its impact on carcinogenesis

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Julia Maria Lipowicz

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

2-in-1: Octafluoroazobenzenes as ON/OFF photoswitches and anion-binding sites in macrocyclic lithium halides receptors

Call: PRELUDIUM 23 , Panel: ST5

Principal investigator: Jakub Narodowiec

Instytut Chemii Organicznej Polska Akademia Nauk

The role of the estrogen receptor GPER1 in ferroptosis disorders in mouse model of mucopolysaccharidosis type I.

Call: PRELUDIUM 23 , Panel: NZ3

Principal investigator: Magdalena Żabińska

Uniwersytet Gdański

Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

Call: OPUS 27 , Panel: NZ7

Principal investigator: dr hab. Agata Faron-Górecka

Instytut Farmakologii PAN

The role of mineralocorticoid receptor in the regulation of pituitary corticotroph cells secretory activity by glucocort...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Mateusz Bujko

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie

Cellular effects in the tumor microenvironment and the potential for targeted delivery of molecules associated with the ...

Call: OPUS 27 , Panel: NZ4

Principal investigator: prof. Magdalena Maria Staniszewska

Katolicki Uniwersytet Lubelski Jana Pawła II

Dual Se-containing 5-HT1A and 5-HT7 biased agonists activating sigma-1 receptor as a hope of finding fast-acting antidep...

Call: OPUS 27 , Panel: NZ7

Principal investigator: prof. Karolina Anna Pytka

Uniwersytet Jagielloński

Functional analysis of detected genetic variants of the PCSK9 gene of unknown significance by using in vitro models

Call: PRELUDIUM 23 , Panel: NZ5

Principal investigator: Monika Marta Targońska

Gdański Uniwersytet Medyczny

Macro-to-Micro: Fabrication of synthetic receptor based microsensors for certain protein sensing

Call: OPUS 27 , Panel: ST11

Principal investigator: dr hab. Piyush Sindhu Sharma

Instytut Chemii Fizycznej Polskiej Akademii Nauk

Mitochondrial metabolism of glycerol as a regulator of lymphocyte homeostasis and pathology

Call: OPUS 27 , Panel: NZ6

Principal investigator: dr Marcin Kaminski

Politechnika Śląska

Neutrophil-targeted immune response as an effective approach in immunotherapyof gastrointestinal cancers

Call: OPUS 27 , Panel: NZ5

Principal investigator: dr Damian Jacenik

Uniwersytet Łódzki

The sensitivity of the androgen receptor, testosterone-dependent life history trade-offs, and their impact on biological...

Call: OPUS 27 , Panel: NZ8

Principal investigator: dr hab. Agnieszka Maria Żelaźniewicz

Uniwersytet Wrocławski

The role of ADP-heptose Acinetobacter baumannii in the pathogenesis of pneumonia of this etiology

Call: PRELUDIUM 23 , Panel: NZ6

Principal investigator: Karolina Justyna Sidor

CENTRUM MEDYCZNE KSZTAŁCENIA PODYPLOMOWEGO

Targeting Proteinopathies: Understanding and Mitigating the Effects of Pathogenic Mutations in Cullin-RING Ubiquitin Lig...

Call: OPUS 27 , Panel: NZ3

Principal investigator: dr hab. Wojciech Mieczysław Pokrzywa

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

Molecular mechanisms underlying the liver injury induced by ulipristal acetate treatment

Call: PRELUDIUM 23 , Panel: NZ7

Principal investigator: Aleksandra Natalia Łupińska

Instytut Rozrodu Zwierząt i Badań Żywności PAN

Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

Call: SONATA 19 , Panel: NZ1

Principal investigator: dr Anna Marta Kocyła

Uniwersytet Wrocławski, Wydział Biotechnologii

Potential pharmacological strategies aimed at alleviating cognitive dysfunctions accompanying oncological therapy while ...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Monika Wierońska

Instytut Farmakologii PAN

Semaglutide and neurodevelopment: investigating risks arising from prenatal exposure to a widely popular drug for diabet...

Call: OPUS 26 , Panel: NZ7

Principal investigator: dr Agnieszka Wnuk

Instytut Farmakologii PAN

Uncovering the Mechanisms Driving Virus-Induced Central Nervous System Disease.

Call: OPUS 26 (LAP) , Panel: NZ3

Principal investigator: dr Aleksandra Rutkowska

Gdański Uniwersytet Medyczny, Centrum Chorób Mózgu

Deciphering the importance of the intracellular FGFR1 module for cell fate

Call: OPUS 26 , Panel: NZ1

Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

Uniwersytet Wrocławski, Wydział Biotechnologii

Investigations on polymeric immunoglobulin receptor (pIgR) expression in equine intestinal epithelial cells in the conte...

Call: SONATA 19 , Panel: NZ6

Principal investigator: dr Agnieszka Teresa Żak-Bochenek

Uniwersytet Przyrodniczy we Wrocławiu

Retro-inverso modification of zinc(II)–GLP-1 receptor agonist complexes – from bioinorganic chemistry to animal studies...

Call: OPUS 26 , Panel: ST5

Principal investigator: dr hab. Magdalena Alina Rowińska-Żyrek

Uniwersytet Wrocławski, Wydział Chemii