Projects funded by the NCN

Abeta 4-x peptides as copper binding molecules resistant to chelating drugs, promoting the formation of amyloid oligomer...

Call: OPUS 8 , Panel: ST5

Principal investigator: prof. Wojciech Bal

Instytut Biochemii i Biofizyki PAN

Dynamic peptide-resorcinarene capsules synthesized by classical and mechanochemical methods

Call: PRELUDIUM 8 , Panel: ST5

Principal investigator: Hanna Jędrzejewska

Instytut Chemii Organicznej PAN

Engineering disulfide bridges in human beta-defensin 3 for novel antibacterial and antifungal activities

Call: SONATA 8 , Panel: ST5

Principal investigator: dr Aleksandra Walewska

Uniwersytet Gdański, Wydział Chemii

Synthesis and tandem mass spectrometry examination of new ionization tags based on thiazolidinecarboxylic acid and oxazo...

Call: PRELUDIUM 8 , Panel: ST5

Principal investigator: Bartosz Setner

Uniwersytet Wrocławski, Wydział Chemii

Determination of the exact structure of the complex (complexes) of AB1-16 peptide with Pd(II) ions using nuclear magneti...

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Mariusz Mital

Instytut Biochemii i Biofizyki PAN

Can Fusobacterium nucleatum adhesion proteins increase prooxidative activity of iron and copper ions?

Call: OPUS 7 , Panel: ST5

Principal investigator: dr Kamila Stokowa-Sołtys

Uniwersytet Wrocławski, Wydział Chemii

Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

Call: PRELUDIUM 7 , Panel: ST5

Principal investigator: Agata Gitlin-Domagalska

Uniwersytet Gdański, Wydział Chemii

Application of macrocycles formed by substituted trithiocyanuric acid as template for self-assembly of peptide chains

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Marta Cal

Uniwersytet Wrocławski, Wydział Chemii

Synthesis and structural study of modified porphyrinoids

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: Justyna Śniechowska

Centrum Badań Molekularnych i Makromolekularnych Polskiej Akademii Nauk

A development of a method of micro-scale synthesis of peptides labelled with stable isotopes for quantitative proteomics

Call: PRELUDIUM 6 , Panel: ST4

Principal investigator: Maciej Modzel

Uniwersytet Wrocławski, Wydział Chemii

Synthesis, biological and biophysical evaluation of mRNA cap-peptide conjugates for targeted delivery of cap analogues t...

Call: OPUS 6 , Panel: ST5

Principal investigator: dr hab. Marzena Jankowska-Anyszka

Uniwersytet Warszawski, Wydział Chemii

Synthesis, physico-chemical and biological studies on macromolecular carriers of antimicrobial peptides

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Urszula Piotrowska

Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Alpha factor of S. cerevisiae yeast: formation of copper and zinc complexes and their biological activity

Call: OPUS 5 , Panel: ST5

Principal investigator: prof. Wojciech Bal

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

Synthesis and pharmacological characterization of novel cyclic opioid peptide analogs incorporating fluoro amino acids.

Call: PRELUDIUM 5 , Panel: NZ7

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

Call: OPUS 1 , Panel: ST5

Principal investigator: dr Marek Łuczkowski

Uniwersytet Wrocławski, Wydział Chemii

Synthesis and fragmentation of peptides conjugated with betaine derivatives - a search for isobaric markers for quantita...

Call: OPUS 5 , Panel: ST4

Principal investigator: prof. Zbigniew Szewczuk

Uniwersytet Wrocławski, Wydział Chemii

Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

Call: OPUS 5 , Panel: ST5

Principal investigator: dr hab. Artur Mucha

Politechnika Wrocławska, Wydział Chemiczny

Synthetic cysteine peptides as molecular layers for studies of interactions between copper ions and beta-amyloid

Call: SONATA 4 , Panel: ST4

Principal investigator: dr Urszula Wawrzyniak

Politechnika Warszawska, Wydział Chemiczny

Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Monika Łęgowska

Uniwersytet Gdański, Wydział Chemii

Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry ...

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Jadwiga Popow - Stellmaszyk

Uniwersytet Gdański, Wydział Chemii

Synthesis and biological studies of conjugates formed by peptide dendrimers and natural polyphenols and their analogs

Call: OPUS 4 , Panel: ST5

Principal investigator: prof. Zofia Lipkowska

Instytut Chemii Organicznej PAN

Quaternary ammonium salts of cryptando-peptidic conjugates. Synthesis and chemical properties.

Call: PRELUDIUM 4 , Panel: ST5

Principal investigator: dr Remigiusz Bąchor

Uniwersytet Wrocławski, Wydział Chemii

Oxidative modification of amino acid residues in proteins - synthetic studies towards selective detection

Call: SONATA 4 , Panel: ST5

Principal investigator: dr Monika Kijewska

Uniwersytet Wrocławski, Wydział Chemii

Characterization of CD44/p53 signaling involved in the CD44-dependent cancer stem cells: small molecules and peptides, t...

Call: MAESTRO 3 , Panel: ST5

Principal investigator: prof. Tadeusz Holak

Uniwersytet Jagielloński, Wydział Chemii

Helical peptides rich in aminoisobutyric acid residues - synthesis, electrical properties and interactions with model li...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Joanna Juhaniewicz

Uniwersytet Warszawski, Wydział Chemii

The impact of synthetic modifications of the histidine side chain on coordination properties of analogues of the N-termi...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: dr Izabela Zawisza

Instytut Biochemii i Biofizyki PAN

A novel strategy for construction of antifungal pro-drugs based on the cell-penetrating peptides

Call: OPUS 3 , Panel: ST5

Principal investigator: prof. Sławomir Milewski

Politechnika Gdańska, Wydział Chemiczny

Synthetic peptides - study on physochemical properties and biological activity

Call: OPUS 3 , Panel: ST5

Principal investigator: dr Wojciech Mrozik

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

Call: PRELUDIUM 3 , Panel: ST5

Principal investigator: Izabela Małuch

Uniwersytet Gdański, Wydział Chemii

Structure-activity relationship of bifunctional peptides, agonists of opioid receptors and antagonists of neurokinin rec...

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Jolanta Dyniewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

Call: OPUS 1 , Panel: ST5

Principal investigator: prof. Krzysztof Rolka

Uniwersytet Gdański, Wydział Chemii

Synthesis of deltorphin I and dermorphin analogues modified with alfa-alkyl-beta-azido(amino)alanine in postion 2 or 3.

Call: PRELUDIUM 2 , Panel: ST5

Principal investigator: Anika Lasota

POLITECHNIKA ŁÓDZKA, Politechnika Łódzka, Wydział Chemiczny,

Novel receptor materials for the construction of a bioelectronic nose for the rapid and efficient detection of lung canc...

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Wojciech Kamysz

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny

Peptide-based luminescent coordination capsules and cages – towards bio-inspired cavities illuminated by chiral light

Call: OPUS 25 , Panel: ST5

Principal investigator: prof. Agnieszka Szumna

Instytut Chemii Organicznej Polskiej Akademii Nauk

The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

Call: PRELUDIUM 22 , Panel: ST5

Principal investigator: Paulina Potok

Uniwersytet Wrocławski, Wydział Chemii

Computational alchemy and experimental validation: a hybrid approach for designing new antimicrobial peptides

Call: PRELUDIUM 22 , Panel: NZ1

Principal investigator: Piotr Chyży

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

Call: OPUS 21 , Panel: NZ7

Principal investigator: prof. Sylwia Rodziewicz-Motowidło

Uniwersytet Gdański, Wydział Chemii

Synthesis and evaluation of PD-L1 inhibitors based on mixed mode scaffolds containing amino acid derivatives, short pept...

Call: SONATA 16 , Panel: ST4

Principal investigator: dr Ewa Surmiak

Uniwersytet Jagielloński, Wydział Chemii

Application of N-(2-thioethyl)glycine analogues in orthogonal cleavage of peptides from solid support

Call: PRELUDIUM 18 , Panel: ST4

Principal investigator: Magdalena Wierzbicka

Uniwersytet Wrocławski, Wydział Chemii

Novel analogs of human cathelicidin (LL-37) with enhanced resistant to enzymatic degradation. Design chemical synthesis ...

Call: PRELUDIUM BIS 1 , Panel: ST4

Principal investigator: prof. Adam Lesner

Uniwersytet Gdański, Wydział Chemii

Evaluation of characteristic interactions of synthetic peptides derived from HarmOBP7 aldehyde binding site.

Call: PRELUDIUM 17 , Panel: ST5

Principal investigator: Tomasz Wasilewski

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

Fundamentals of copper exchange kinetics between model peptides and small molecules.

Call: PRELUDIUM 16 , Panel: ST5

Principal investigator: Radosław Kotuniak

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

De novo designed, structurally extended peptide foldamers and their use for construction of PD-1/PD-L1 interaction inhib...

Call: OPUS 16 , Panel: ST5

Principal investigator: dr hab. Łukasz Berlicki

Politechnika Wrocławska

Searching for mu opioid receptor peptide agonists with G protein/beta-arrestin biased profile and their pharmacological ...

Call: SONATA 14 , Panel: ST5

Principal investigator: dr Justyna Piekielna-Ciesielska

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Lipid nanoparticles loaded with antibacterial peptides as an alternative treatment for bacterial infections

Call: PRELUDIUM 15 , Panel: ST5

Principal investigator: dr Katarzyna Reczyńska-Kolman

Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

Synthesis of new functional cages based on trigonal peptidic building blocks by dynamic covalnt chemistry

Call: PRELUDIUM 15 , Panel: ST5

Principal investigator: Marcin Grajda

Instytut Chemii Organicznej Polskiej Akademii Nauk

Opioid-induced analgesia and hyperalgesia in neuropathic pain - mechanisms and druggable targets

Call: OPUS 15 , Panel: NZ7

Principal investigator: prof. Barbara Przewłocka

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Spectroscopic exploration of conformationally variable metal-bound peptide monolayers: towards novel versatile optical n...

Call: OPUS 15 , Panel: ST4

Principal investigator: dr Agata Królikowska

Uniwersytet Warszawski, Wydział Chemii

New class of nucelus penetrating peptides. Design, synthesis and mechanism of action

Call: OPUS 14 , Panel: ST5

Principal investigator: dr hab. Magdalena Wysocka

Uniwersytet Gdański, Wydział Chemii

Inhibitors of BTLA-HVEM complex formation as potential targets for cancer immunotheraphy

Call: SONATA 13 , Panel: ST5

Principal investigator: dr Marta Spodzieja

Uniwersytet Gdański, Wydział Chemii