Projects funded by the NCN
Fluorescent substrates of neutrophil proteinases: design, chemical synthesis , selection by the combinatorial chemistry approach and their use in the characterization of selected enzymes
2012/07/N/ST5/00178
Keywords:
combinatorial chemistry fluorescent peptides neutrophil proteinases proteinase 3 human neutrophil elastase NSP4
Descriptors:
- ST5_16:
- NZ1_2: Biochemistry
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Uniwersytet Gdański, Wydział Chemii
woj. pomorskie
Principal investigator (from the host institution):
dr Jadwiga Popow - Stellmaszyk
Number of co-investigators in the project: 2
Call: PRELUDIUM 4 - announced on 2012-09-15
Amount awarded: 149 940 PLN
Project start date (Y-m-d): 2013-07-09
Project end date (Y-m-d): 2016-07-08
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- mieszadło z funkcją grzania.
- wyparka obrotowa (15 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Articles in post-conference publications (1)
- Usefulness evaluation of marking the proteinase 3 activity using a fluorescent substrate in a differential diagnostics of anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis and infectious diseasesAuthors:M. Ziętkiewicz, Z. Czuszyńska, A. Masiak, J. Popow-Stellmaszyk, M. Wysocka, A. Lesner, Z. ZdrojewskiAcademic press:Scandinavian Journal of Rheumatology , Wydawca: Taylor & FrancisStatus:SubmittedDOI:brak - link to the publication
- A new proteinase 3 substrate with improved selectivity over human neutrophil elastase.Authors:J. Popow-Stellmaszyk, M. Wysocka, A. Lesner, B. Korkmaz, K. RolkaAcademic press:Analytical Biochemistry (rok: 2013, tom: 442, strony: 75-82), Wydawca: Elsevier Inc.Status:PublishedDOI:10.1016/j.ab.2013.07.028 - link to the publication
- Chemical synthesis and potential use of new intramolecular quenched substrates for human neutrophil elastase and proteinase 3 in the diagnosis of lung diseases.Authors:J. Popow-Stellmaszyk, B. Popławska-Wiśniewska, M. Wysocka, J. Chorostowska-Wynimko, K. Rolka, A. LesnerConference:33 Europejskie Sympozjum Peptydowe (rok: 2014, ), Wydawca: John Wiley & Sons, Ltd. Journal of Peptide ScienceData:konferencja 31.08.-05.09.2014Status:Published