Projects funded by the NCN

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177 projects found matching your search criteria :

  1. Phosphorylation-Dependent Regulation of IRS2 by DYRK1A: Implications for Diabetes Therapy

    Call: PRELUDIUM 24 , Panel: NZ1

    Principal investigator: Alicja Bis

    Uniwersytet Jagielloński

  2. Identification of the regulon and interactome of orphan histidine kinase in Streptomyces coelicolor A3(2)

    Call: PRELUDIUM 24 , Panel: NZ2

    Principal investigator: Mateusz Wenecki

    Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

  3. Graphene Oxide-Immobilized Adenylate Kinase as a Molecular Mediator of Vascular Homeostasis

    Call: PRELUDIUM 24 , Panel: NZ1

    Principal investigator: Agata Wikarska

    Uniwersytet Mikołaja Kopernika

  4. Analysis of pharmacokinetic, pharmacodynamic and molecular determinants of intolerance and resistance to the Janus kinas...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Marta Katarzyna Karaźniewicz-Łada

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  5. Mechanisms of Antidepressant Action of Psilocybin: The Role of 5-HT2B-5-HT1A Receptor Dimerization and GSK-3β Activation...

    Call: OPUS 27 , Panel: NZ7

    Principal investigator: dr hab. Agata Faron-Górecka

    Instytut Farmakologii PAN

  6. Regulatory role of the N-terminal fragment of diacylglycerol kinase-ε and its contribution to the pro-inflammatory respo...

    Call: PRELUDIUM 23 , Panel: NZ3

    Principal investigator: Gabriela Traczyk

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  7. Precision double strike against non-small cell lung cancer. Insights into multidirectional therapies and the landscape o...

    Call: OPUS 27 , Panel: NZ5

    Principal investigator: dr Katarzyna Anna Malarz

    Politechnika Śląska

  8. Selective inhibition of Janus kinases for the treatment of autoimmune hepatitis: Translational PK/PD modelling from mole...

    Call: SONATA 19 , Panel: NZ7

    Principal investigator: dr Artur Świerczek

    Uniwersytet Jagielloński, Collegium Medicum

  9. Zn2+-dependent competition between CD4 and CD8α coreceprtor for Lck tyrosine kinase

    Call: SONATA 19 , Panel: NZ1

    Principal investigator: dr Anna Marta Kocyła

    Uniwersytet Wrocławski, Wydział Biotechnologii

  10. Deciphering the importance of the intracellular FGFR1 module for cell fate

    Call: OPUS 26 , Panel: NZ1

    Principal investigator: dr hab. Małgorzata Urszula Zakrzewska

    Uniwersytet Wrocławski, Wydział Biotechnologii

  11. First-in-class dual modulators of necroptosis kinases and 5-HT6 receptors as an innovative approach to develop an effect...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: prof. Jadwiga Handzlik

    Uniwersytet Jagielloński, Collegium Medicum

  12. Targeting adenylate kinase 4 (AK4) as a new paradigm in the treatment of non-small cell lung cancer: discovery and evalu...

    Call: OPUS 26 , Panel: NZ7

    Principal investigator: dr Magdalena Wujak

    Uniwersytet Mikołaja Kopernika, Collegium Medicum im. Ludwika Rydygiera w Bydgoszczy

  13. Novel aspects of the mechanisms of vascular toxicity of tyrosine kinase inhibitors: studies on their proinflammatory act...

    Call: OPUS 26 , Panel: NZ5

    Principal investigator: dr Tomasz Krzysztof Prajsnar

    Uniwersytet Jagielloński, Wydział Biologii

  14. Exploring kinase hyperactivation as an innovative approach for chemo-immunotherapy for B cell acute lymphoblastic leukem...

    Call: PRELUDIUM BIS 5 , Panel: NZ7

    Principal investigator: dr hab. Małgorzata Firczuk

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  15. Molecular mechanisms of DNA damage triggered by PIM kinases inhibition and its consequences for activation of innate imm...

    Call: OPUS 25 , Panel: NZ5

    Principal investigator: prof. Przemysław Juszczyński

    Instytut Hematologii i Transfuzjologii

  16. Investigating the mechanisms of CD20 downregulation triggered by tyrosine kinase inhibitors in Philadelphia chromosome-p...

    Call: PRELUDIUM 22 , Panel: NZ5

    Principal investigator: Krzysztof Domka

    Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

  17. Regulacja procesu deoksyhypuzynacji przez kinazy białkowe

    Call: PRELUDIUM 22 , Panel: NZ1

    Principal investigator: Paweł Kochanowski

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  18. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Aleksandra Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  19. INVADOPODIA IN AXL-DRIVEN CANCER INVASION AND DRUG RESISTANCE

    Call: OPUS 25 , Panel: NZ3

    Principal investigator: dr Daria Paulina Zdżalik-Bielecka

    Uniwersytet Warszawski, Wydział Biologii

  20. Targeting Energy Metabolism for Precision Cancer Therapy: Novel Inhibitors of LDH-A and PDK1 as Potential Strategies to ...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Marika Anna Frańczak

    Gdański Uniwersytet Medyczny, Wydział Lekarski

  21. The potassium puzzle: unraveling the connection between the potassium channel and lipid kinases in kidney functioning

    Call: OPUS 25 , Panel: NZ1

    Principal investigator: dr hab. Piotr Rajmund Koprowski

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  22. Dissecting the regulatory interplay between proteases and protein kinases in acute lymphoblastic leukemia using mass cyt...

    Call: OPUS 24 , Panel: NZ5

    Principal investigator: dr hab. Marcin Łukasz Poręba

    Politechnika Wrocławska

  23. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Iwona Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  24. A double whammy for the NF-κB signalling pathway: development of TAK1 and IKKβ degraders against inflammation-driven dis...

    Call: OPUS 24 (LAP) , Panel: NZ7

    Principal investigator: dr hab. Anna Karolina Więckowska

    Uniwersytet Jagielloński, Collegium Medicum

  25. Thermodynamic contribution of halogen bonds in protein-ligand systems. Design, synthesis, and thermodynamic studies of m...

    Call: PRELUDIUM 21 , Panel: ST4

    Principal investigator: dr Sławomir Jan Kasperowicz

    Instytut Biochemii i Biofizyki PAN

  26. Smart tissue engineering to change the paradigm of diabetes treatment

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr Anna Czarna

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  27. Unraveling mechanisms and physiological outcome of lipid-evoked regulation of proteostasis in the intestine.

    Call: OPUS 23 , Panel: NZ4

    Principal investigator: dr hab. Grzegorz Piotr Sumara

    Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

  28. The SnRK2 kinases as key proteins in seeds biology- unraveling new molecular mechanisms determining seed germination abi...

    Call: OPUS 23 , Panel: NZ3

    Principal investigator: dr Anna Marta Kulik

    Instytut Biochemii i Biofizyki PAN

  29. Role of RelA(p65) and cRel phosphorylations and their kinases in the biology of Diffuse-large B-cell lymphoma and Hodgki...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr Maciej Stefan Szydłowski

    Instytut Hematologii i Transfuzjologii

  30. Novel broad-spectrum central nervous system active substances: optimization of their multi-target profile

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Anna Kaczor

    Uniwersytet Medyczny w Lublinie, Wydział Farmaceutyczny

  31. Small-molecule inhibitors of protein aggregation and ER stress as a novel strategy against neurodegeneration in the cour...

    Call: PRELUDIUM BIS 3 , Panel: NZ5

    Principal investigator: prof. Ireneusz Jacek Majsterek

    Uniwersytet Medyczny w Łodzi

  32. New strategies in the treatment of non-small cell lung cancer based on silk nanocarriers targeting tumor vascularization

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Anna Katarzyna Florczak-Substyk

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  33. Research of multifunctional compounds targeting neuroinflammation and cholinergic deficit in Alzheimer's disease

    Call: OPUS 22 (LAP) , Panel: NZ7

    Principal investigator: prof. Kinga Aleksandra Sałat

    Uniwersytet Jagielloński, Collegium Medicum

  34. Investigation of the MLK4 biology in breast cancer and search for new therapeutic strategies using innovative PROTAC com...

    Call: SONATA BIS 11 , Panel: NZ5

    Principal investigator: dr Anna Agnieszka Marusiak

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  35. RE-SENSE: Dual-loaded lipid nanoparticles to overcome the resistance of non-small cell lung cancer cells to personalized...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Mikołaj Czajkowski

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  36. Expression, regulation and function of super-enhancer non-coding RNAs in Diffuse Large B-Cell Lymphoma (DLBCL)

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: dr Sonia Maria Dębek

    Instytut Hematologii i Transfuzjologii

  37. Investigating the role of the focal adhesion kinase and its related signaling pathways in glucocorticoid- and stress-ind...

    Call: PRELUDIUM 20 , Panel: NZ4

    Principal investigator: Michał Józef Wilczkowski

    Instytut Farmakologii PAN

  38. MLK4 signaling in DNA damage response and cancer therapy

    Call: PRELUDIUM 20 , Panel: NZ3

    Principal investigator: Dawid Grzegorz Mehlich

    Międzynarodowy Instytut Mechanizmów i Maszyn Molekularnych Polskiej Akademii Nauk

  39. AXL receptor signaling in cancer cell growth and drug resistance

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: prof. Marta Elżbieta Miączyńska

    Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

  40. Iron chelators as tyrosine kinase inhibitors - a new strategy for the treatment of glioblastoma multiforme

    Call: PRELUDIUM BIS 2 , Panel: NZ5

    Principal investigator: dr hab. Anna Dominika Mrozek-Wilczkiewicz

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

  41. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej PAN

  42. A novel approach based on the optimized multidrug combination for glioblastoma treatment.

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: prof. Małgorzata Kucińska

    Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu

  43. FAST interactions in cell death regulation

    Call: PRELUDIUM 19 , Panel: NZ1

    Principal investigator: Daria Martyna Dawidziak

    Uniwersytet Warszawski, Wydział Chemii

  44. OMENTIN1 as a new regulator of female reproduction - expression and role in the pituitary - ovary axis. Study on swine m...

    Call: OPUS 19 , Panel: NZ9

    Principal investigator: dr hab. Agnieszka Małgorzata Rak

    Uniwersytet Jagielloński, Wydział Biologii

  45. Towards innovative strategy for treatment of Alzheimer's Disease via dual inhibition of receptor 5-HT6 and kinase CDK5.

    Call: PRELUDIUM 19 , Panel: NZ7

    Principal investigator: Sylwia Sudoł-Tałaj

    Uniwersytet Jagielloński, Collegium Medicum

  46. The proangiogenic functions of PIM kinases in plasma cell myeloma

    Call: ETIUDA 8 , Panel: NZ5

    Principal investigator: Filip Aleksander Garbicz

    Instytut Hematologii i Transfuzjologii

  47. New insights into multifaceted targeted therapy for treatment of glioblastoma multiforme.

    Call: OPUS 18 , Panel: NZ5

    Principal investigator: dr Katarzyna Anna Malarz

    UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

  48. Determination of the role of present in extracelluar space integrin-linked kinase (ILK) in adhesion, migration/invasion ...

    Call: PRELUDIUM BIS 1 , Panel: NZ3

    Principal investigator: dr hab. Antonina Joanna Mazur

    Uniwersytet Wrocławski, Wydział Biotechnologii

  49. Molecular mechanisms of interplay between RORγ/RORγT receptors and cyclin-dependent kinase inhibitor (AT7519). Analysis ...

    Call: PRELUDIUM 18 , Panel: NZ7

    Principal investigator: Kaja Urszula Karaś

    Instytut Biologii Medycznej PAN

  50. Comprehensive bioinformatic analysis of known and novel human microbiome kinases and pseudokinases.

    Call: PRELUDIUM 18 , Panel: NZ2

    Principal investigator: dr Marcin Tomasz Gradowski

    Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Instytut Biologii

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