Projects funded by the NCN

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74 projects found matching your search criteria :

  1. Covalent inhibiors of bacterial ureases - design, activity and mode of binding

    Call: PRELUDIUM 9 , Panel: NZ1

    Principal investigator: dr Katarzyna Macegoniuk

    Politechnika Wrocławska, Wydział Chemiczny

  2. Synthesis and study of anticancer activities and affinities to kinesin of selected sandwich and half-sandwich organometa...

    Call: OPUS 9 , Panel: ST5

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  3. Synthesis of fluorogenic substrates, inhibitors and activity-based probes of human neutrophil proteinase NSP4 and its ev...

    Call: OPUS 8 , Panel: ST5

    Principal investigator: prof. Adam Lesner

    Uniwersytet Gdański, Wydział Chemii

  4. Design and synthesis of probes for RabGGTase profiling and their application for identification of the site of phosphono...

    Call: SONATA BIS 4 , Panel: ST5

    Principal investigator: dr hab. Katarzyna Błażewska

    Politechnika Łódzka, Wydział Chemiczny

  5. Study of casein kinase CK2 inhibition mechanisms

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Maria Bretner

    Politechnika Warszawska, Wydział Chemiczny, Wydział Chemiczny

  6. Design and synthesis of phosphoroorganic antagonists of BIR domain of apoptosis inhibitor proteins (IAP)

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: dr Agnieszka Łupicka-Słowik

    Politechnika Wrocławska, Wydział Chemiczny

  7. Novel polyelectrolytes as potential inhibitors of HSV-1 virus - synthesis, properties and mechanism of action

    Call: OPUS 7 , Panel: ST5

    Principal investigator: prof. Maria Nowakowska

    Uniwersytet Jagielloński, Wydział Chemii

  8. Design, chemical synthesis and biological activity of inhibitors of matriptase-2.

    Call: PRELUDIUM 7 , Panel: ST5

    Principal investigator: Agata Gitlin-Domagalska

    Uniwersytet Gdański, Wydział Chemii

  9. Poszukiwanie inhibitorów oddziaływania białek MDM2-p53. Trójpodstawione pochodne 1,5-dihydro-2H-pirol-2-onu.

    Call: ETIUDA 2 , Panel: ST5

    Principal investigator: Ewa Wrona

    Uniwersytet Jagielloński, Wydział Chemii

  10. Structure optimization of inhibitor for paracaspase MALT1

    Call: PRELUDIUM 6 , Panel: ST5

    Principal investigator: dr Paulina Kasperkiewicz

    Politechnika Wrocławska, Wydział Chemiczny

  11. Bioactive organoselenium compounds in self-organizing systems: design, synthesis and biological evaluation

    Call: SONATA 5 , Panel: ST5

    Principal investigator: dr Magdalena Piętka-Ottlik

    Politechnika Wrocławska, Wydział Chemiczny

  12. Studies on the metal ions impact on the structure and functions of peptidic inhibitors of aggregation of proteins involv...

    Call: OPUS 1 , Panel: ST5

    Principal investigator: dr Marek Łuczkowski

    Uniwersytet Wrocławski, Wydział Chemii

  13. Design and synthesis of acylpeptide hydrolase inhibitors as potential inducers of apoptosis in tumor cells

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Maciej Walczak

    Politechnika Wrocławska, Wydział Chemiczny

  14. Design and synthesis of selective and irreversible inhibitors of HAT protease.

    Call: PRELUDIUM 5 , Panel: ST5

    Principal investigator: Marcin Skoreński

    Politechnika Wrocławska, Wydział Chemiczny

  15. The search for novel human proteasome inhibitors and fluorogenic substrates.

    Call: SONATA 1 , Panel: ST5

    Principal investigator: dr Dawid Dębowski

    Uniwersytet Gdański, Wydział Chemii

  16. RNA chaperone activity of HIV-2 Gag and nuclocapsid proteins: implications for the design of the new retroviral inhibito...

    Call: SONATA 1 , Panel: NZ1

    Principal investigator: dr Katarzyna Pachulska-Wieczorek

    Instytut Chemii Bioorganicznej PAN

  17. New methods for mRNA 5' end labeling and examples of their application in studies on RNA metabolism and searching for in...

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  18. Morita-Baylis-Hillman adducts as substrates in the synthesis of biologically active organophosphorus compounds

    Call: OPUS 5 , Panel: ST5

    Principal investigator: dr hab. Artur Mucha

    Politechnika Wrocławska, Wydział Chemiczny

  19. Design, chemical synthesis and enzymatic evaluation of peptidic substrates and inhibitors of cathepsin C

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: dr Monika Łęgowska

    Uniwersytet Gdański, Wydział Chemii

  20. Synthesis and preliminary studies on biological activity of glycosyltransferases natural substrates analogues, derivativ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Roman Komor

    Politechnika Śląska, Wydział Chemiczny

  21. Synthesis and analysis of potential furin inhibitors in the development of the new therapeutic strategies against viral ...

    Call: PRELUDIUM 4 , Panel: ST5

    Principal investigator: Monika Lewandowska-Goch

    Uniwersytet Gdański, Wydział Chemii

  22. Diaminophosphonates as specific inhibitors of Neisseria meningitidis aminopeptidase N - synthesis and biological activit...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Ewelina Węglarz-Tomczak

    Politechnika Wrocławska, Wydział Chemiczny

  23. Organometallic inhibitors of tubulin polymerisation. Synthesis, anticancer activities and tubulin affinities.

    Call: OPUS 3 , Panel: ST5

    Principal investigator: dr hab. Damian Plażuk

    Uniwersytet Łódzki, Wydział Chemii

  24. Modifications of aglycones of leucomycins via Michael addition and Huisgen dipolar cycloaddition as a new routes of synt...

    Call: SONATA BIS 1 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

  25. Identification of amino acid residues located in positions P7 and P8 of model inhibitor of proprotein convertases that d...

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: Izabela Małuch

    Uniwersytet Gdański, Wydział Chemii

  26. Synthesis of mononucleotide N2,N2,7-trimethylguanosine cap analogues as translation inhibitors in Ascaris suum

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Karolina Piecyk

    Uniwersytet Warszawski, Wydział Chemii

  27. Role of ruthenium complexes interaction with NO in the context of angiogenesis inhibition.

    Call: PRELUDIUM 3 , Panel: ST5

    Principal investigator: dr Maria Oszajca

    Uniwersytet Jagielloński, Wydział Chemii

  28. Conjugates of cap analogs with nanomaterials and biomolecules with potential applications in pharmacology or diagnostics

    Call: SONATA 1 , Panel: ST5

    Principal investigator: dr Joanna Kowalska

    Uniwersytet Warszawski, Wydział Fizyki

  29. Peptide splicing - the mechanism and its application for designing compounds with potential use in medicinal practice

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Krzysztof Rolka

    Uniwersytet Gdański, Wydział Chemii

  30. New approaches towards modulating selective and functional activities of antisense oligonucleotides

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  31. Design, synthesis and biological evaluation of Steroid Sulfatase Inhibitors based on organophosphorus compounds.

    Call: SONATA 2 , Panel: NZ7

    Principal investigator: dr Sebastian Demkowicz

    POLITECHNIKA GDAŃSKA

  32. Design and synthesis of new rifampicin analogs as a source of effective bacterial RNA polymerase inhibitors

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr hab. Piotr Przybylski

    Uniwersytet im. Adama Mickiewicza, Wydział Chemii

  33. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  34. Synthesis and biological activity evaluation of new hybrid derivatives of tacrine and melatonin as potential cholinester...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: dr Anna Zawadzka

    Uniwersytet Warszawski, Wydział Chemii

  35. Search for novel IKK-β inhibitors in the context of diseases with neuroinflammatory origin – structure-based drug design...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Emilia Sługocka

    Uniwersytet Jagielloński, Collegium Medicum

  36. The design and development of the peptide inhibitors library targeting Zn(II)-binding site of matrix metalloproteinases ...

    Call: PRELUDIUM 22 , Panel: ST5

    Principal investigator: Paulina Potok

    Uniwersytet Wrocławski, Wydział Chemii

  37. Designing Active Inhibitors of SARS-CoV-2 Methyltransferases

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Alex Matsuda

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  38. Feel the chemistry if you're close enough - proximity-induced SuFEx ligation for mRNA biology and medicine

    Call: OPUS 25 , Panel: ST5

    Principal investigator: prof. Jacek Jemielity

    Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

  39. Targeted inhibition of hypusination pathway

    Call: OPUS 24 , Panel: NZ7

    Principal investigator: dr Przemysław Grudnik

    Uniwersytet Jagielloński, Małopolskie Centrum Biotechnologii Uniwersytetu Jagiellońskiego

  40. Computational deciphering of pro-ferroptotic cell death protein machinery as a fundamental step in the search for therap...

    Call: SONATA BIS 12 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

  41. Design, synthesis and in vitro and in vivo studies of anticancer potential of phosphonic and phosphinic analogs of sulfo...

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Tadeusz Gajda

    POLITECHNIKA ŁÓDZKA, Wydział Chemiczny

  42. Structure-guided design of histone demethylase inhibitors for cancer therapy.

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Piotr Małecki

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  43. Inhibiting the Mitochondrial Intermembrane Space Assembly pathway as a newapproach to prevent metabolic reprogramming of...

    Call: OPUS 22 , Panel: NZ5

    Principal investigator: dr hab. Carlo Vascotto

    Instytut Hematologii i Transfuzjologii

  44. Search for Inhibitors of Human δ1-Pyrroline-5-Carboxylate Reductase 1 (PYCR1) as Lead Molecules for the Development of N...

    Call: OPUS 22 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  45. Blocking the TNF-TNFR2 interactions as a novel approach to the ovarian carcinoma treatment

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: prof. Sylwia Rodziewicz-Motowidło

    Uniwersytet Gdański, Wydział Chemii

  46. Blocking HVEM/LIGHT interactions using peptides - an innovative approach to immunosuppression

    Call: PRELUDIUM BIS 2 , Panel: ST4

    Principal investigator: dr hab. Adam Sieradzan

    Uniwersytet Gdański, Wydział Chemii

  47. Design of high selective and safe juvenile hormone epoxide hydrolases inhibitors targeting selected pests based on the c...

    Call: OPUS 20 , Panel: ST4

    Principal investigator: dr hab. Artur Góra

    Politechnika Śląska, Centrum Biotechnologii

  48. Novel L-asparaginases as potential therapeutic agents and antimicrobial targets: structural and functional studies of en...

    Call: OPUS 19 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

  49. Inhalable polymeric delivery systems of antibiotics and quorum sensing inhibitors for the treatment of respiratory infec...

    Call: OPUS 18 , Panel: ST5

    Principal investigator: prof. Elżbieta Pamuła

    Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Wydział Inżynierii Materiałowej i Ceramiki

  50. Molecular mechanisms, signal transduction and inhibition of PEBP1-15LOX protein complex triggering the ferroptotic cell ...

    Call: SONATA 15 , Panel: ST4

    Principal investigator: dr Karolina Mikulska-Rumińska

    Uniwersytet Mikołaja Kopernika w Toruniu, Wydział Fizyki, Astronomii i Informatyki Stosowanej

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