Projects funded by the NCN

Simultaneous stimulation of muscarinic M4 receptor and selected receptors involved in the regulation of glutamate releas...

Call: OPUS 9 , Panel: NZ7

Principal investigator: dr hab. Joanna Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Study of SNAP-25 protein expression, NMR metabolomic analysis and behavioral characteristics in animal models of infanti...

Call: OPUS 8 , Panel: NZ4

Principal investigator: prof. Jerzy Łazarewicz

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Participation of transient receptor potential (TRP) channels premeable for calcium ions in memory formation and retrieva...

Call: OPUS 8 , Panel: NZ4

Principal investigator: dr hab. Elżbieta Salińska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

New selective antagonists of ionotropic glutamate non-NMDA receptors

Call: OPUS 8 , Panel: NZ7

Principal investigator: dr Ewa Szymańska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

The mechanism of neurotoxic action of benzophenone-3

Call: OPUS 8 , Panel: NZ7

Principal investigator: prof. Bogusława Budziszewska

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Research of mechanisms of antidepressant action of group II and III mGlu receptor ligands and their role in inducing rap...

Call: OPUS 7 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii PAN

Searching for molecular basis of addiction-prone phenotype - a role of astrocyte biomarkers (xc-, EAAT2) and metabotropi...

Call: PRELUDIUM 6 , Panel: NZ7

Principal investigator: Ewa Niedzielska-Andres

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

Chemical sensors for selective determination of chosen amino acids of gluten proteins using molecularly imprinted polyme...

Call: PRELUDIUM 6 , Panel: ST5

Principal investigator: dr Zofia Iskierko

Instytut Chemii Fizycznej PAN

Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural,...

Call: OPUS 6 , Panel: NZ4

Principal investigator: dr hab. Jadwiga Wardas

Instytut Farmakologii Polskiej Akademii Nauk

New 1,3,4-thiadiazole derivatives as inhibitors of critical steps of the glutamine-glutamate cycle in glioblastoma cells...

Call: SONATA 6 , Panel: NZ7

Principal investigator: dr hab. Monika Szeliga

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

Contribution of the glutamate-mediated transmission changes in pedunculopontine tegmental nucleus and nucleus accumbens ...

Call: PRELUDIUM 5 , Panel: NZ4

Principal investigator: Karolina Plucińska

Uniwersytet Gdański, Wydział Biologii

Role of astrocytic NMDA receptors in ammonia-induced brain edema associated with hepatic encephalopathy.

Call: HARMONIA 4 , Panel: NZ3

Principal investigator: prof. Jan Albrecht

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

The group III metabotropic glutamate receptors as a target for future antypsychotic drugs

Call: MAESTRO 3 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii PAN

The role of the mGlu5-D2 heterodimeric receptor complexes in the extinction of drug seeking behavior associated with dep...

Call: SONATA 2 , Panel: NZ7

Principal investigator: dr Małgorzata Frankowska

Instytut Farmakologii Polskiej Akademii Nauk, Instytut Farmakologii Polskiej Akademii Nauk

New insight into the mechanism of cytotoxic brain edema in acute liver failure: focus on the functionality of mitochondr...

Call: SONATA 19 , Panel: NZ5

Principal investigator: dr Mariusz Popek

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Role of Astrocytes in Chronic Stress Resilience

Call: OPUS 26 , Panel: NZ4

Principal investigator: dr Piotr Michaluk

Instytut Biologii Doświadczalnej im. Marcelego Nenckiego Polskiej Akademii Nauk

Potential pharmacological strategies aimed at alleviating cognitive dysfunctions accompanying oncological therapy while ...

Call: OPUS 26 , Panel: NZ5

Principal investigator: dr hab. Joanna Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

New positive allosteric modulators of EAAT2 glutamate transporter as candidates for treatment of neurological and psychi...

Call: OPUS 23 , Panel: NZ7

Principal investigator: prof. Krzysztof Kamiński

Uniwersytet Jagielloński, Collegium Medicum

Role of SAT1 glutamine transporter in the neurotransmission balance: implications for anxiety-related disorders.

Call: OPUS 20 , Panel: NZ5

Principal investigator: prof. Magdalena Zielińska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Quinoxalino-2,3-diones as potent tools for exploration of ionotropic kainate receptors

Call: OPUS 20 , Panel: NZ7

Principal investigator: dr hab. Ewa Szymańska

Uniwersytet Jagielloński, Collegium Medicum

Combined administration of muscarinic receptor antagonists and group II/III metabotropic glutamate (mGlu) receptor ligan...

Call: OPUS 19 , Panel: NZ7

Principal investigator: prof. Andrzej Pilc

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The role of nitric oxide-dependent pathways in the procognitive effects of muscarinic and metabotropic glutamate recepto...

Call: OPUS 17 , Panel: NZ7

Principal investigator: dr hab. Joanna Wierońska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Genesis of dendritic spine head protrusion (SHP) formation

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: Ewa Bączyńska

Instytut Biologii Doświadczalnej im. M. Nenckiego Polskiej Akademii Nauk

The role of selected metabotropic glutamate receptors in the mechanism of rapid antidepressant effect of RS-ketamine and...

Call: OPUS 14 , Panel: NZ7

Principal investigator: dr hab. Agnieszka Pałucha-Poniewiera

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Role of astrocytic NMDA receptors in the regulation of glutamine synthetase activity in cultured mouse astrocytes. Attem...

Call: PRELUDIUM 14 , Panel: NZ3

Principal investigator: dr Katarzyna Skowrońska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Interdisciplinary approach to the role of the GABA-ergic and glutamatergic neurotransmission in the effects of mephedron...

Call: OPUS 13 , Panel: NZ7

Principal investigator: dr hab. Barbara Budzyńska

Uniwersytet Medyczny w Lublinie, Wydział Biomedyczny

Investigation of the mechanisms of the neuroprotective effect of group II metabotropic receptors (mGluR2/3) agonist in a...

Call: PRELUDIUM 12 , Panel: NZ7

Principal investigator: dr Ewelina Bratek

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Role of glutamine synthesis in the initial phase of temporal lobe epilepsy in the juvenile rat lithium-pilocarpine model...

Call: OPUS 12 , Panel: NZ4

Principal investigator: prof. Jan Albrecht

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Role of Sp1 transcription factor in the regulation of astrocytic glutamine transporter SN1 expression: effect of ammonia...

Call: PRELUDIUM 11 , Panel: NZ4

Principal investigator: Katarzyna Dąbrowska

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego Polskiej Akademii Nauk

Evaluation of anticancer potential of glutamine metabolism modulation in multiple myeloma sensitive and resistant to che...

Call: PRELUDIUM 11 , Panel: NZ5

Principal investigator: Monika Prełowska

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

The importance of interaction between NMDA and AMPA receptors and scaffolding proteins in the excitatory synaptic in the...

Call: OPUS 11 , Panel: NZ7

Principal investigator: dr hab. Magdalena Sowa-Kućma

Uniwersytet Rzeszowski, Kolegium Nauk Medycznych

Pharmacological properties and neurotoxicity of novel NBOMe derivatives

Call: OPUS 11 , Panel: NZ7

Principal investigator: prof. Krystyna Gołembiowska

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

The effect of the metabotropic glutamatergic receptor ligands on potentiating the antidepressant-like actvity of scopola...

Call: PRELUDIUM 10 , Panel: NZ7

Principal investigator: Karolina Podkowa

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

Effects of maternal high-fat or high-sugar diet on the impaired NMDA receptor composition and regulation in offspring in...

Call: SONATA 10 , Panel: NZ7

Principal investigator: dr hab. Lucyna Pomierny-Chamioło

Uniwersytet Jagielloński, Collegium Medicum, Wydział Farmaceutyczny

Synthesis of new glutamate receptors antagonists and extensive investigation of their effect on tumor cells in the prese...

Call: OPUS 9 , Panel: ST5

Principal investigator: prof. Maria Bretner

Politechnika Warszawska, Wydział Chemiczny

Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resist...

Call: OPUS 9 , Panel: NZ7

Principal investigator: prof. Mariusz Papp

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk