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Searching for molecular basis of addiction-prone phenotype - a role of astrocyte biomarkers (xc-, EAAT2) and metabotropic glutamate receptors mGluR1, mGluR5 and mGluR2/3 in the mechanism of vulnerabiility to addiction.

2013/11/N/NZ7/01617

Keywords:

addiction phenotyping glutamate

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_2: Environment and health risks

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Ewa Niedzielska-Andres 

Number of co-investigators in the project: 2

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 149 240 PLN

Project start date (Y-m-d): 2014-08-27

Project end date (Y-m-d): 2017-11-26

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (3)
  1. Changes in the glutamate biomarker expression in rats vulnerable or resistant to the rewarding effects of cocaine and their reversal by ceftriaxone
    Authors:
    Ewa Niedzielska-Andres, Józef Mizera, Anna Sadakierska-Chudy, Lucyna Pomierny-Chamioło, Małgorzata Filip
    Academic press:
    Behavioural Brain Research (rok: 2019, tom: 370, strony: ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.bbr.2019.111945 - link to the publication
  1. Ceftriaxone as an anti - relapse drug for cocaine use disorder – preclinical evaluation
    Authors:
    Niedzielska - Andres E, Pomierny - Chamioło L, Filip M
    Conference:
    2nd Central European Biomedical Congress (rok: 2016, ), Wydawca: IF PAN
    Data:
    konferencja 15-18.06.2016
    Status:
    Published
    DOI:
    link to the publication
  2. Could antibiotics cure the addiction? Preclinical evaluation of efficacy of an antibiotic-ceftriaxone in cocaine addiction treatment
    Authors:
    Ewa Niedzielska-Andres, Lucyna Pomierny-Chamioło, Maria Walczak, Małgorzata Filip
    Conference:
    Aspects of Neuroscience (rok: 2017, ), Wydawca: Aspects of Neuroscience
    Data:
    konferencja 24-26.11
    Status:
    Published
  3. DIFFERENCES IN BRAIN GLUTAMATE MGLUR2/3, MGLUR1 AND MGLUR5 RECEPTORS EXPRESSION AFTER COCAINE ADMINISTRATION IN RATS SHOWING ADDICTION-VULNERABLE OR ADDICTION-RESISTANT PHENOTYPE.
    Authors:
    Niedzielska-Andres E, Filip M, Pomierny-Chamiolo L
    Conference:
    FENS-SFN SUMMER SCHOOL 2016 " CELLULAR MECHANISMS AND NETWORKS IN ADDICTION" (rok: 2016, ), Wydawca: FENS - Federation of European Neuroscience Societies, SFN- Society for Neuroscience
    Data:
    konferencja 29 maj – 4 czerwiec
    Status:
    Published

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